Catalog No.
AMD82401
Biological activity
Measured by its ability to bind recombinant Mouse Ephrin‑A1 in a functional ELISA. Immobilized recombinant Mouse EPHA2 (Cat #: AMD82401) at 2 µg/mL (100 µL/well) can bind recombinant Mouse Ephrin-A1 with a linear range of 0.078-5 ng/mL. Optimal dilutions should be determined by each laboratory for each application.
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Ala22-Asn535
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q03145
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ephrin type-A receptor 2, 2.7.10.1, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2, ECK
Cracking the Kinase Code: Urinary Biomarkers as Early Alarms for AAA Rupture-A Pilot Study., PMID:40507607
Eph Receptor Tyrosine Kinases Are Functional Entry Receptors for Murine Gammaherpesvirus 68., PMID:40501621
Developing and Characterizing the Tumor-Targeting Efficiency of an Anti-EphA2-CD11b Bispecific Antibody., PMID:40434019
EphrinA2 promotes glioma cell migration and invasion through EphA2 and FAK., PMID:40413506
Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation., PMID:40411427
Targeting Glioblastoma Stem Cells via EphA2: Structural Insights into the RNA Aptamer A40s for Precision Therapy., PMID:40408544
Loss of primary cilia promotes EphA2-mediated endothelial-to-mesenchymal transition in the ovarian tumor microenvironment., PMID:40397771
Genome-wide enhancer-gene regulatory maps of liver reveal novel regulatory mechanisms underlying NAFLD pathogenesis., PMID:40375105
Development of a PSMA and EphA2 dual-receptor-activated fluorescent probe for wash-free prostate cancer cell imaging., PMID:40315731
Cataract-related mutations in EphA2: a survey of literature data and the relevance of the receptor Sam domain., PMID:40310271
Competitive inhibition of Ephrin-A1 and EphA2 binding by Perillaldehyde leads to decreased TRPM2 expression and reduced mitochondrial damage in vascular endothelial cells., PMID:40288150
Zmynd11 is essential for neurogenesis by coordinating H3K36me3 modification of Epha2 and PI3K signaling pathway., PMID:40281637
Cholesterol-dependent dimerization and conformational dynamics of EphA2 receptors from coarse-grained and all-atom simulations., PMID:40280119
Targeting Signaling Excitability in Cervical and Pancreatic Cancer Cells Through Combined Inhibition of FAK and PI3K., PMID:40243705
Fibronectin-dependent integrin signaling drives EphA2 expression in vascular smooth muscle cells., PMID:40241381
Development of an anti-human EphA2 monoclonal antibody Ea2Mab-7 for multiple applications., PMID:40236294
Bayesian analysis and efficient algorithms for single-molecule fluorescence data and step counting., PMID:40235987
Mannan is a context-dependent shield that modifies virulence in Nakaseomyces glabratus., PMID:40233931
EphA2-targeted alpha-particle theranostics for enhancing PDAC treatment., PMID:40225586
Increased Serum EphA2 is Associated with Disease Severity in Pediatric Patients with Asthma., PMID:40224169
EphA2 and phosphoantigen-mediated selective killing of medulloblastoma by γδT cells preserves neuronal and stem cell integrity., PMID:40190167
Developing CAR-T/NK cells that target EphA2 for non-small cell lung cancer treatment., PMID:40181964
Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line., PMID:40168262
Advancements and challenges in CAR T cell therapy for pediatric brain tumors: A review., PMID:40156311
TAK-901, a novel EPHA2 inhibitor as a therapeutic strategy against prostate cancer., PMID:40101850
Broad-spectrum antiviral activity of Ganoderma microsporum immunomodulatory protein: Targeting glycoprotein gB to inhibit EBV and HSV-1 infections via viral fusion blockage., PMID:40101816
Comprehensive clinical and genetic characterization of hyperprogressive biliary tract cancer during PD-1 blockade monotherapy: case report and literature review., PMID:40087618
miR-1297 is frequently downmodulated in flat epithelial atypia of the breast and promotes mammary neoplastic transformation via EphrinA2 regulation., PMID:40082972
Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptor., PMID:40069393
Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role., PMID:40060438
Differential association of EphA2 intracellular regions in biased signaling., PMID:40049409
Stress Response Kinase MK2 Induces Non-canonical Activation of EphA2 in EML4-ALK Lung Cancer Cells., PMID:40024717
Super-enhancer-driven EFNA1 fuels tumor progression in cervical cancer via the FOSL2-Src/AKT/STAT3 axis., PMID:39964764
Identifying prognostic biomarkers and immune interactions in ovarian cancer associated with perfluorooctanoic acid exposure: Insights from comparative toxicogenomics and molecular docking studies., PMID:39955862
Correction: TR4 nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression., PMID:39948066
Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations., PMID:39942820
Theranostics using 89Zr/177Lu-labeled antibody targeting erythropoietin-producing hepatocellular A2 (EphA2)., PMID:39934299
Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis., PMID:39926431
A peptide-based fluorescent bioprobe for EphA2-overexpressing tumor targeting and image-guided surgical resection., PMID:39904197
USP5 Binds and Stabilizes EphA2 to Increase Nasopharyngeal Carcinoma Radioresistance., PMID:39897046
Sex-specific transcriptomic profiling reveals key players in bone loss associated with Alzheimer's disease., PMID:39875754
Targeted internalization and activation of glycosidic switch liposomes by a biological macromolecule mPEG×EphA2 increases therapeutic efficacy against lung cancer., PMID:39842595
Regulation of inflammatory responses: Harnessing the Ruan Mai Jian targeting of EphA2/ephrinA1 pathway to enhance atherosclerosis amelioration., PMID:39842373
Ephrin A1 functions as a ligand of EGFR to promote EMT and metastasis in gastric cancer., PMID:39838173
Cholesterol-Dependent Dimerization and Conformational Dynamics of EphA2 Receptors: Insights from Coarse-Grained and All-Atom Simulations., PMID:39829830
Site-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags., PMID:39826875
Proteins Involved in Endothelial Function and Inflammation Are Implicated in Cerebral Small Vessel Disease., PMID:39818967
Bioinformatic Analysis for Exploring Target Genes and Molecular Mechanisms of Cadmium-Induced Nonalcoholic Fatty Liver Disease and Targeted Drug Prediction., PMID:39806544
First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation., PMID:39802100
RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis., PMID:39797421
For research use only. Not for human or drug use.
