Catalog No.
AHF92701
Biological activity
Measured by its ability to enhance neurite outgrowth of rat embryonic cortical neurons (E16-E18). Optimal neurite outgrowth was observed when neurons were plated on 96 well culture plates that had been precoated with 50 µL/well of the rhCNTN2 (Cat #: AHF92701) solution at 10-25 µg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu29-Asn1012
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02246
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Contactin-2, TAX1, TAG1, Axonal glycoprotein TAG-1, TAX-1, Axonin-1, CNTN2, AXT, Transient axonal glycoprotein 1
Exploring human plasma proteomic variations in mucolipidosis type IV., PMID:40486934
A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC., PMID:40379966
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
Identification of CNTN2 as a genetic modifier of PIGA-CDG in a family with incomplete penetrance and in Drosophila., PMID:39947185
Cryo-EM structures of the full-length human contactin-2., PMID:39702996
Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia., PMID:39611166
FUT8 Regulates Cerebellar Neurogenesis and Development Through Maintaining the Level of Neural Cell Adhesion Molecule Cntn2., PMID:39604780
Contactin proteins in cerebrospinal fluid show different alterations in dementias., PMID:39317877
Identification of CNTN2 as a genetic modifier of PIGA-CDG through pedigree analysis of a family with incomplete penetrance and functional testing in Drosophila., PMID:39211166
Molecular mechanism of contactin 2 homophilic interaction., PMID:38968938
Anti-neurofascin-155 antibody mediated a distinct phenotype of chronic inflammatory demyelinating polyradiculoneuropathy., PMID:38771386
IKVAV functionalized oriented PCL/Fe3O4 scaffolds for magnetically modulating DRG growth behavior., PMID:38761494
Integrative proteomic and transcriptomic analysis in the female goat ovary to explore the onset of puberty., PMID:38688390
Neonatal Hypoxia-Ischemia alters Brain-Derived Contactin-2-Positive Extracellular Vesicles in the Mouse Plasma., PMID:38513760
Gene-gene interaction network analysis indicates CNTN2 is a candidate gene for idiopathic generalized epilepsy., PMID:38460076
Integrated analysis of plasma proteome and cortex single-cell transcriptome reveals the novel biomarkers during cortical aging., PMID:37539343
Whole exome sequencing identified five novel variants in CNTN2, CARS2, ARSA, and CLCN4 leading to epilepsy in consanguineous families., PMID:37359369
The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression., PMID:36734072
Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data., PMID:36482464
Characterization of the patients with antibodies against nodal-paranodal junction proteins in chronic inflammatory demyelinating polyneuropathy., PMID:36401951
Phosphacan acts as a repulsive cue in murine and rat cerebellar granule cells in a TAG-1/GD3 rafts-dependent manner., PMID:36227633
Exome-Wide Association Study Reveals Host Genetic Variants Likely Associated with the Severity of COVID-19 in Patients of European Ancestry., PMID:36143338
AutoCaSc: Prioritizing candidate genes for neurodevelopmental disorders., PMID:35998261
Putative Candidate Drug Targets for Sarcopenia-Related Traits Identified Through Mendelian Randomization Analysis of the Blood Proteome., PMID:35938019
A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism., PMID:35870967
Genome-Wide CRISPR/Cas9 Library Screening Identified that DUSP4 Deficiency Induces Lenvatinib Resistance in Hepatocellular Carcinoma., PMID:35864956
Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors., PMID:35685361
Identification of Novel Cerebrospinal Fluid Biomarkers for Cognitive Decline in Aneurysmal Subarachnoid Hemorrhage: A Proteomic Approach., PMID:35602555
OKN-007 Alters Protein Expression Profiles in High-Grade Gliomas: Mass Spectral Analysis of Blood Sera., PMID:35053843
Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening., PMID:34698769
Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy., PMID:34675937
Neural cell adhesion molecule is required for ventricular conduction system development., PMID:34100064
Neuronal, but not glial, Contactin 2 negatively regulates axon regeneration in the injured adult optic nerve., PMID:33469963
Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:33460483
Implication of Contactins in Demyelinating Pathologies., PMID:33451101
MiR-34a regulates Schwann cell proliferation and migration by targeting CNTN2., PMID:33044326
Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells., PMID:32962862
Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies., PMID:32806791
Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2., PMID:32601750
Identification of hub genes and small-molecule compounds in medulloblastoma by integrated bioinformatic analyses., PMID:32328342
TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation., PMID:31995756
Cord Blood-Derived Exosomal CNTN2 and BDNF: Potential Molecular Markers for Brain Health of Neonates at Risk for Iron Deficiency., PMID:31623079
Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system., PMID:31326446
Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression., PMID:31306714
Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression., PMID:31176559
ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment., PMID:30598502
Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia., PMID:30242309
miR-3075 Inhibited the Migration of Schwann Cells by Targeting Cntn2., PMID:30078168
Discovery of Novel Cell Surface Markers for Purification of Embryonic Dopamine Progenitors for Transplantation in Parkinson's Disease Animal Models., PMID:29848781
Genetic variants in autism-related CNTNAP2 impair axonal growth of cortical neurons., PMID:29788201
For research use only. Not for human or drug use.
