Catalog No.
AHF67301
Biological activity
Measured by its ability to enhance anti-CD3-induced IFN gamma secretion of mouse CD3+ T cells. The ED50 for this effect is 0.5-2.5 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln30-Trp248
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P78410
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BTF4, BT3.2, BTF3, BTN3A2, Butyrophilin subfamily 3 member A2
Genome-wide Mendelian randomization study identifies therapeutic targets for diabetic microangiopathy., PMID:40349847
Identifying novel protein biomarkers with cross-psychiatric disorders effects and potential intervention targets: Evidence from proteomic-Mendelian randomization., PMID:40334965
Identifying Immune Response Protein Biomarkers in Parkinson's-Related Cognitive Impairment and Depression., PMID:40332667
BTN3A2 interacted with MFGE8 to alleviate preeclampsia by promoting ferroptosis and inhibiting angiogenesis., PMID:40147528
Chronic inflammation response as a key factor in polycystic ovary syndrome among patients with bipolar disorder., PMID:39988136
Integrative Multi-omics Analysis and Mendelian Randomization Reveal Potential Therapeutic Targets and their Stratification in Lung Squamous Cell Carcinoma., PMID:39936431
Identification and validation of depression-associated genetic variants in the UK Biobank cohort with transcriptome and DNA methylation analyses in independent cohorts., PMID:39897774
Genome-wide Mendelian randomization mapping the influence of plasma proteome on major depressive disorder., PMID:39892755
Plasma proteomics identifies proteins and pathways associated with incident depression in 46,165 adults., PMID:39424455
Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2., PMID:39142074
Genome-Wide Mendelian Randomization Study Reveals Druggable Genes for Cerebral Small Vessel Disease., PMID:39114924
A Ménage à trois: NLRC5, immunity, and metabolism., PMID:39035010
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome., PMID:38898508
Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing., PMID:38374404
A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing., PMID:37993425
Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information., PMID:37415601
Significance of an altered lncRNA landscape in schizophrenia and cognition: clues from a case-control association study., PMID:37009928
Potential diagnostic markers and therapeutic targets for rheumatoid arthritis with comorbid depression based on bioinformatics analysis., PMID:36911710
Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells., PMID:36824912
Multiplex proteomics using proximity extension assay for the identification of protein biomarkers predictive of acute graft-vs.-host disease in allogeneic hematopoietic cell transplantation., PMID:36655501
Long noncoding RNA profiling reveals that LncRNA BTN3A2 inhibits the host inflammatory response to Eimeria tenella infection in chickens., PMID:36091044
Analysis and Experimental Validation of Rheumatoid Arthritis Innate Immunity Gene CYFIP2 and Pan-Cancer., PMID:35898498
BTN3A2 Expression Is Connected With Favorable Prognosis and High Infiltrating Immune in Lung Adenocarcinoma., PMID:35873496
Multi-omics analysis of the expression and prognostic value of the butyrophilins in breast cancer., PMID:34411352
BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells., PMID:34260935
Prognostic and Therapeutic Significance of BTN3A Proteins in Tumors., PMID:34149914
High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis., PMID:33101298
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk., PMID:32724101
BTN3A2 serves as a prognostic marker and favors immune infiltration in triple-negative breast cancer., PMID:31692043
Metabolites downstream of predicted loss-of-function variants inform relationship to disease., PMID:31679996
Analysis of macaque BTN3A genes and transcripts in the extended MHC: conserved orthologs of human γδ T cell modulators., PMID:31384962
Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells., PMID:31227581
Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci., PMID:31133542
Type 1 Diabetes Mellitus-Associated Genetic Variants Contribute to Overlapping Immune Regulatory Networks., PMID:30524468
Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology., PMID:29339503
Expression QTL analysis of glaucoma endophenotypes in the Norfolk Island isolate provides evidence that immune-related genes are associated with optic disc size., PMID:29215094
CpG-specific methylation at rheumatoid arthritis diagnosis as a marker of treatment response., PMID:28447857
MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer., PMID:28409241
Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family., PMID:28382515
Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer., PMID:28246015
Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection., PMID:25928882
Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin., PMID:25637025
Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells., PMID:23833237
Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure., PMID:22966150
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies., PMID:22846996
BTN3A2 expression in epithelial ovarian cancer is associated with higher tumor infiltrating T cells and a better prognosis., PMID:22685580
Differential role for CD277 as a co-regulator of the immune signal in T and NK cells., PMID:21918970
Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex., PMID:19295542
A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane., PMID:12124930
For research use only. Not for human or drug use.
