Catalog No.
AHF64501
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized rhGPC5 (Cat #: AHF64501) at 5 µg/mL (100 µL/well) can bind rhFGF-basic with a linear range of 0.16-10 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu25-Thr554
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P78333
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GPC5, Glypican-5
Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer's disease., PMID:40467545
Profiling 92 circulating neurobiological proteins identifies novel candidate biomarkers of long-term cognitive outcome after ischemic stroke., PMID:40316737
Glypican3 and serglycin as potential biomarkers involved in the pathogenesis of ovarian endometriosis., PMID:40139079
Astrocyte glypican 5 regulates synapse maturation and stabilization., PMID:40048429
Dysregulation of Glypicans and Notum in Osteoarthritis: Plasma Levels, Bone Marrow Mesenchymal Stromal Cells and Osteoblasts., PMID:38786073
Circadian gene Per3 promotes astroblastoma progression through the P53/BCL2/BAX signalling pathway., PMID:37951372
[Correlation of the expressions of 4-HNE and GPC5 with the progression of prostate cancer]., PMID:37846827
[Multiple sclerosis in the Republic of Bashkortostan: population-specific genetic predictors and the results of a 20-year clinical follow-up study]., PMID:37560832
Integrated analysis of plasma proteome and cortex single-cell transcriptome reveals the novel biomarkers during cortical aging., PMID:37539343
Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Precancer., PMID:37410084
Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity., PMID:37126556
Screening and characterisation of a novel efficient tumour cell-targeting peptide derived from insulin-like growth factor binding proteins., PMID:36974745
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior., PMID:36944188
Prognostic value of GPC5 polymorphism rs2352028 and clinical characteristics in Chinese lung cancer patients., PMID:36165234
The novel lncRNA GPC5-AS1 stabilizes GPC5 mRNA by competitively binding with miR-93/106a to suppress gastric cancer cell proliferation., PMID:35183057
GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion., PMID:34079082
The Glypican proteoglycans show intrinsic interactions with Wnt-3a in human prostate cancer cells that are not always associated with cascade activation., PMID:33947326
Distinct diagnostic and prognostic values of Glypicans gene expression in patients with hepatocellular carcinoma., PMID:33902495
Feingold syndrome type 2 in a patient from China., PMID:33818875
Identification of candidate SNPs and genes associated with anti-RGNNV using GWAS in the red-spotted grouper, Epinephelus akaara., PMID:33609701
Subcellular localization of glypican-5 is associated with dynamic motility of the human mesenchymal stem cell line U3DT., PMID:33606708
Glypican-1, -3, -5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma., PMID:33512817
Prognostic value of Glypican family genes in early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy and possible mechanisms., PMID:33302876
Age-related DNA methylation in paired normal and tumour breast tissue in Chinese breast cancer patients., PMID:32970968
Effect of genetic polymorphisms on therapeutic response in multiple sclerosis relapsing-remitting patients treated with interferon-beta., PMID:32800273
Exome sequencing identifies somatic mutations in novel driver genes in non-small cell lung cancer., PMID:32629428
A de novo 13q31.3 microduplication encompassing the miR-17 ~ 92 cluster results in features mirroring those associated with Feingold syndrome 2., PMID:32473250
An investigation of genetic polymorphisms in heparan sulfate proteoglycan core proteins and key modification enzymes in an Australian Caucasian multiple sclerosis population., PMID:32398079
The Role of Cell Growth-Related Gene Copy Number Variation in Autoimmune Thyroid Disease., PMID:31494809
A 4-gene panel predicting the survival of patients with glioblastoma., PMID:31081973
MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5., PMID:30951720
Analysis of chosen SNVs in GPC5, CD58 and IRF8 genes in multiple sclerosis patients., PMID:30818222
Genome-wide association study using diversity outcross mice identified candidate genes of pancreatic cancer., PMID:30578891
Long non-coding RNA Hotair promotes gastric cancer progression via miR-217-GPC5 axis., PMID:30557546
Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats., PMID:30541833
The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity., PMID:30414409
Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy., PMID:29765130
High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5., PMID:29407175
Rem2 signaling affects neuronal structure and function in part by regulation of gene expression., PMID:29066292
Overexpression of Glypican 5 (GPC5) Inhibits Prostate Cancer Cell Proliferation and Invasion via Suppressing Sp1-Mediated EMT and Activation of Wnt/β-Catenin Signaling., PMID:28893348
SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes., PMID:28077070
Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a., PMID:27806326
[Investigation of Gene Expression Profile of A549 Cells after Overexpression of GPC5
by High Throughput Transcriptome Sequencing]., PMID:27561806
miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma., PMID:27554041
GPC5, a novel epigenetically silenced tumor suppressor, inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma., PMID:27157618
Glypican-5 is a tumor suppressor in non-small cell lung cancer cells., PMID:27092337
Prognostic significance of GPC5 expression in patients with prostate cancer., PMID:26631038
The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5., PMID:26098560
Polymorphisms in C-reactive protein and Glypican-5 are associated with lung cancer risk and Gartrokine-1 influences Cisplatin-based chemotherapy response in a Chinese Han population., PMID:25999661
Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney., PMID:25987249
For research use only. Not for human or drug use.
