Catalog No.
AHF15001
Biological activity
Immobilized human GDNF at 1 μg/mL (100 μL/well) can bind human GFRA1 (Cat #: AHF15001) with a linear range of 2-332 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala19-Ser429
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P56159
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GDNFRA, RET ligand 1, GDNFR-alpha-1, GDNF family receptor alpha-1, RETL1, GFR-alpha-1, TGF-beta-related neurotrophic factor receptor 1, TRNR1, GDNF receptor alpha-1, GFRA1
Molecular mechanisms of GDNF/GFRA1/RET and PI3K/AKT/ERK signaling interplay in neuroprotection: Therapeutic strategies for treating neurological disorders., PMID:40101330
Development of a prognostic model based on the ceRNA network in Triple-Negative Breast cancer., PMID:40034665
Enhancing spermatogonial stem cell differentiation: The role of alpha-ketoglutarate in in-Vitro cultures., PMID:39970551
Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts of Physical Activity and its Protective Role Against Dementia., PMID:39867359
Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality., PMID:39753750
GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand., PMID:39630029
Functionally redundant roles of ID family proteins in spermatogonial stem cells., PMID:39332405
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis., PMID:39324575
PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1., PMID:39285301
WTAP-mediated m6A modification of circ_0032463 promotes osteosarcoma progression by sponging miR-145-5p and regulating GFRA1 expression., PMID:39243199
Exploring the globoid cell leukodystrophy protein network and therapeutic interventions., PMID:39103379
GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma., PMID:39085346
Acute effects of atrazine on the immunoexpressions of sertoli and germ cells molecular markers, cytokines, chemokines, and sex hormones levels in mice testes and epididymides., PMID:39019188
The effects of vitamin E supplementation on sperm parameters, chromatin integrity, and gene expression before and after freezing in aged mice., PMID:38853131
Plasma proteome association with coronary heart disease and carotid intima media thickness: results from the KORA F4 study., PMID:38811951
Electroacupuncture improves gastrointestinal motility through a central-cholinergic pathway-mediated GDNF releasing from intestinal glial cells to protect intestinal neurons in Parkinson's disease rats., PMID:38744625
Maternal Diet High in Linoleic Acid Alters Renal Branching Morphogenesis and mTOR/AKT Signalling Genes in Rat Fetal Kidneys., PMID:38731907
Mesenchymal cells regulate enteric neural crest cell migration via RET-GFRA1b trans-signaling., PMID:38581949
JMJD3 regulate H3K27me3 modification via interacting directly with TET1 to affect spermatogonia self-renewal and proliferation., PMID:38424516
Regulation of spermatogonial stem cell differentiation by Sertoli cells-derived exosomes through paracrine and autocrine signaling., PMID:38291718
Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice., PMID:38271475
Analysis and application of RNA binding protein gene pairs to predict the prognosis of gastric cancer., PMID:37539127
circGFRA1: A circular RNA with important roles in human carcinogenesis., PMID:37285736
Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction., PMID:37238631
Interplay of spermatogonial subpopulations during initial stages of spermatogenesis in adult primates., PMID:37222410
Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling., PMID:37178997
Improving effects of telmisartan on spermatogenic disorder induced by fractionated low-dose irradiation in mice., PMID:37093439
A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis., PMID:36898512
A Fundamental Research in In Vitro Spermatogonial Stem Cell Culturing: What Are Clump Cells?, PMID:36847738
Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson's disease., PMID:36820885
Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux., PMID:36808605
Cytoprotective Effects of Human Platelet Lysate during the Xeno-Free Culture of Human Donor Corneas., PMID:36769200
The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells., PMID:36768269
ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model., PMID:36758123
Gene expression profile for different susceptibilities to sound stimulation: a comparative study on brainstems between two inbred laboratory mouse strains., PMID:36451107
Missense Variants in GFRA1 and NPNT Are Associated with Congenital Anomalies of the Kidney and Urinary Tract., PMID:36292572
F1 Male Sterility in Cattle-Yak Examined through Changes in Testis Tissue and Transcriptome Profiles., PMID:36230452
Circular RNA circDOCK1 contributes to osteosarcoma progression by acting as a ceRNA for miR-936 to regulate LEF1., PMID:36147545
Sexually dimorphic transcriptional programs of early-phase response in regenerating peripheral nerves., PMID:35983069
LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer., PMID:35832649
Genome-Wide Placental Gene Methylations in Gestational Diabetes Mellitus, Fetal Growth and Metabolic Health Biomarkers in Cord Blood., PMID:35721735
Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance., PMID:35435331
The nerve-tumour regulatory axis GDNF-GFRA1 promotes tumour dormancy, imatinib resistance and local recurrence of gastrointestinal stromal tumours by achieving autophagic flux., PMID:35288241
Tumoral Neuroligin 1 Promotes Cancer-Nerve Interactions and Synergizes with the Glial Cell Line-Derived Neurotrophic Factor., PMID:35053395
GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration., PMID:35020233
Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function., PMID:34748545
Biallelic loss-of-function variants of GFRA1 cause lethal bilateral renal agenesis., PMID:34737117
A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis., PMID:34686326
CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression., PMID:34668628
GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism., PMID:34593305
For research use only. Not for human or drug use.
