Catalog No.
AHE61401
Biological activity
Measured by its ability to mediate mouse embryonic fibroblast cell (Balb/3T3) adhesion. rhCCN3/NOV (Cat #: AHE61401), immobilized at 10 µg/mL, 100 µL/well, will mediate >30% Balbc/3T3 cell adhesion (3 x 10^4 cells/well added).
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Thr32-Met357
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P48745
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Insulin-like growth factor-binding protein 9, CCN family member 3, IGF-binding protein 9, IGFBP9, Cellular communication network factor 3, CCN3, IGFBP-9, Nephro blastoma-overexpressed gene protein homolog, Protein NOV homolog, NOV, IBP-9, NOVH, NovH
Nephroblastoma Overexpressed Protein (NOV/CCN3) Elevated Expression of Inflammation Regulators in a Model of Sepsis-Induced Lung Injury., PMID:40156746
Associations of 2923 plasma proteins with incident inflammatory bowel disease in a prospective cohort study and genetic analysis., PMID:40118817
Expression and clinical significance of CCN5 and the oestrogen receptor in advanced breast cancer., PMID:40016720
CircFak promotes mechanical force-induced osteogenesis via FAK/AKT phosphorylation., PMID:39894158
A Highly Bioactive Organic-Inorganic Nanoparticle for Activating Wnt10b Mediated Osteogenesis by Specifically Anchor CCN3 Protein., PMID:39840496
Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection., PMID:39738466
CCN3: lactational bone booster., PMID:39734229
Exploring the Role of Ccn3 in Type III Cell of Mice Taste Buds., PMID:39709613
Cellular communication network factor 3 contributes to the pathological process of rheumatoid arthritis through promoting cell senescence and osteoclastogenesis in the joint., PMID:39549484
CCN3/NOV as a potential therapeutic target for diverticular disease: A proteome-wide Mendelian randomization study., PMID:39533633
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy., PMID:39151294
Amino-truncated NOV expression and its correlation with clinicopathologic features, prognosis, metastasis, and chemoresistance in bladder cancer., PMID:39097778
CCN3 maintains bone density during lactation., PMID:39043957
Profile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C., PMID:38997072
A maternal brain hormone that builds bone., PMID:38987585
FRMD6 determines the cell fate towards senescence: involvement of the Hippo-YAP-CCN3 axis., PMID:38926528
CD4+CD25+ regulatory T cells ex vivo generated from autologous naïve CD4+ T cells suppress EAE progression., PMID:38491084
CCN3/NOV Serum Levels in Non-alcoholic Fatty Liver Disease (NAFLD) Patients in Comparison with the Healthy Group and its Correlation with TNF-α and IL-6., PMID:38415473
CCN3, POSTN, and PTHLH as potential key regulators of genomic integrity and cellular survival in iPSCs., PMID:38375508
A Comprehensive Study on the Association between Plasma NOV/CCN3 Levels and Insulin Resistance in Childhood Obesity., PMID:38310860
CCN3/NOV inhibition attenuates oxidative stress-induced apoptosis of mouse neural stem/progenitor cells by blocking the activation of p38 MAPK: An in vitro study., PMID:38199307
ANGPTL4 May Regulate the Crosstalk Between Intervertebral Disc Degeneration and Type 2 Diabetes Mellitus: A Combined Analysis of Bioinformatics and Rat Models., PMID:38161353
Blocking CCN2 Reduces Established Palmar Neuromuscular Fibrosis and Improves Function Following Repetitive Overuse Injury., PMID:37762168
Insights into the interaction of human serum albumin with ionic liquids - Thermodynamic, spectroscopic and molecular modelling studies., PMID:37499721
The advance of CCN3 in fibrosis., PMID:37378812
CCN3/NOV Regulates Proliferation and Neuronal Differentiation in Mouse Hippocampal Neural Stem Cells via the Activation of the Notch/PTEN/AKT Pathway., PMID:37373471
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets., PMID:37245185
Structural insights into regulation of CCN protein activities and functions., PMID:37245184
Significance of CCNs in liver regeneration., PMID:37202628
CCN proteins: opportunities for clinical studies-a personal perspective., PMID:37195381
The Critical Role of the Adipocytokine NOV in Obstructive Sleep Apnea Induced Cardiometabolic Dysfunction: A Review., PMID:37185878
Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes., PMID:36998974
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease., PMID:36863609
A biallelic variant of DCAF13 implicated in a neuromuscular disorder in humans., PMID:36797467
Do not overwork: cellular communication network factor 3 for life in cartilage., PMID:36745317
CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer., PMID:36737605
Myeloid CCN3 protects against aortic valve calcification., PMID:36670446
The matricellular protein CCN3 supports lung endothelial homeostasis and function., PMID:36573684
The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2., PMID:36529291
Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing., PMID:36499638
Protocol for CRISPR/Cas Genome Editing for Investigating Cell Communication Network., PMID:36370349
Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction., PMID:36231029
Single nucleotide mutation changes the capability of CCN3 in osteosarcoma cell invasion and differentiation., PMID:35858494
[Scutellarin alleviates lipopolysaccharide-induced renal injury via mediating cysteine-rich protein 61-connective tissue growth factor-nephroblastoma overexpressed gene 1 expression to inhibit nuclear factor-κB signaling pathway]., PMID:35692206
Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin-Yang Collaboration., PMID:35682564
An Immune-Related Gene Signature for Predicting Neoadjuvant Chemoradiotherapy Efficacy in Rectal Carcinoma., PMID:35603163
Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms., PMID:35397287
Nephroblastoma overexpressed protein (NOV) enhances 5-Fu-mediated inhibitory effect of colorectal cancer cell proliferation via JNK/AP-1/caspase-8/caspase-3 pathway., PMID:35201461
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes., PMID:35038159
Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives., PMID:34940056
For research use only. Not for human or drug use.
