Catalog No.
AME28301
Biological activity
Measured in a cell proliferation assay using mouse T cells (HT-2). The ED50 for this effect is 15-58 ng/mL, corresponding to a specific activity of 1.72×10^4 - 6.67×10^4 units/mg.
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Asn49-Ser162
Nature
Recombinant
Endotoxin level
<1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P48346
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL15, IL-15, Interleukin-15,
IL-15-Activated CD38+HLA-DR+CD8+ T cells induce liver injury in cirrhosis via JAK/STAT5 and PI3K/mTOR pathways., PMID:40399368
The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES+ Tr1-Like Cells., PMID:40375822
Genetically engineered K562 cells augment NK cell cytotoxicity against acute myeloid leukemia and reduce dependency on IL-15., PMID:40372524
Oncolytic Adenovirus Armoring with CXCL9 and IL15 Shows Potent Antitumor Activity and Boosts CAR-T Therapy for Prostate Cancer., PMID:40346805
Robust differentiation of NK cells from MSLN.CAR-IL-15-engineered human iPSCs with enhanced antitumor efficacy against solid tumors., PMID:40315330
Interleukin-15 gene polymorphism in children with celiac disease: a single-center experience., PMID:40266334
Off-the-shelf invariant NKT cells expressing anti-PSCA CAR and IL-15 promote pancreatic cancer regression in mice., PMID:40231459
CLEC12A-directed immunocytokine with target cell-restricted IL-15 activity for treatment of acute myeloid leukemia., PMID:40213559
Elevation of Plasma IL-15 and RANTES as Potential Biomarkers of Healing in Chronic Venous Ulcerations: A Pilot Study., PMID:40149931
Cellular interactions within the immune microenvironment underpins resistance to cell cycle inhibition in breast cancers., PMID:40032842
IL-15 transpresentation by ovarian cancer cells improves CD34+ progenitor-derived NK cell's anti-tumor functionality., PMID:39960378
IL-15 secreted by keratinocytes induces melanogenesis through STAT3/5 signaling pathway in melan-a melanocytes., PMID:39951112
First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer., PMID:39948608
Neutralizing IL-15 Inhibits Tissue-Damaging Immune Response in Ex Vivo Cultured Untreated Celiac Intestinal Mucosa., PMID:39937025
Interim report on engineered NK cell trial in lung cancer refractory to immune checkpoint inhibitors., PMID:39903538
A New Antibody-Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia., PMID:39858511
Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15., PMID:39800376
Anti-CD8/IL-15 (N72D)/sushi fusion protein: A promising strategy for improvement of cancer immunotherapy., PMID:39631260
Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers., PMID:39604730
Oncolytic virus encoding 4-1BBL and IL15 enhances the efficacy of tumor-infiltrating lymphocyte adoptive therapy in HCC., PMID:39567771
In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions., PMID:39531313
Cytokine-armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells., PMID:39400317
IL15RA-STAT3-GPX4/ACSL3 signaling leads to ferroptosis resistance in pancreatic cancer., PMID:39396119
CD151 identifies an NK cell subset that is enriched in COVID-19 patients and correlates with disease severity., PMID:39374860
Single-cell RNA sequencing reveals anti-tumor potency of CD56+ NK cells and CD8+ T cells in humanized mice via PD-1 and TIGIT co-targeting., PMID:39318093
IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation., PMID:39302113
Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors., PMID:39303144
IL-10 and TGF-β, but Not IL-17A or IFN-γ, Potentiate the IL-15-Induced Proliferation of Human T Cells: Association with a Decrease in the Expression of β2m-Free HLA Class I Molecules Induced by IL-15., PMID:39273322
An improved approach to generate IL-15+/+/TGFβR2-/- iPSC-derived natural killer cells using TALEN., PMID:39260365
Immune system adaptation during gender-affirming testosterone treatment., PMID:39232147
Elevated IL-15 levels in systemic lupus erythematosus: potential pathogenesis insight and therapeutic target., PMID:39217881
Immune dysregulation is an important factor in the underlying complications in Influenza infection. ApoH, IL-8 and IL-15 as markers of prognosis., PMID:39176097
Neoprzewaquinone A alters the migration, phagocytosis and energy metabolism of IL-15-induced HMC3 cells., PMID:39128414
Striking a balance: the Goldilocks effect of CD8α expression on NK cells., PMID:39087476
HIV-1 latency reversal and immune enhancing activity of IL-15 is not influenced by sex hormones., PMID:39078714
Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells., PMID:39053944
89Zr-immunoPET-guided selection of a CD33xIL15 fusion protein optimized for antitumor immune cell activation and in vivo tumour retention in acute myeloid leukaemia., PMID:38987489
In vitro IL-15-activated human naïve CD8+ T cells down-modulate the CD8β chain and become CD8αα T cells., PMID:38903513
IL-15 gene mutation as a molecular risk factor in acute lymphoid leukemia., PMID:38814240
CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival., PMID:38812569
Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation., PMID:38805302
IFN-α/β/IFN-γ/IL-15 pathways identify GBP1-expressing tumors with an immune-responsive phenotype., PMID:38758367
cellPLATO - an unsupervised method for identifying cell behaviour in heterogeneous cell trajectory data., PMID:38738282
Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation., PMID:38729924
The alteration of NK cells phenotypes related to the functions and dengue disease outcomes., PMID:38697295
Self-sufficient primary natural killer cells engineered to express T cell receptors and interleukin-15 exhibit improved effector function and persistence., PMID:38690288
IL-15 as a key regulator in NK cell-mediated immunotherapy for cancer: From bench to bedside., PMID:38669950
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization., PMID:38668728
Bone marrow CD8+ Trm cells induced by IL-15 and CD16+ monocytes contribute to HSPC destruction in human severe aplastic anemia., PMID:38636890
Interleukin-15 is a hair follicle immune privilege guardian., PMID:38581915
For research use only. Not for human or drug use.
