Catalog No.
AHD82701
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human EPHB2 (Cat #: AHD82701) is coated at 2 μg/mL, recombinant human Ephrin-B2 Fc Chimera binds with an apparent Kd <0.1 nM.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Val19-Leu543
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P29323
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EPHT3, EPTH3, ERK, Developmentally-regulated Eph-related tyrosine kinase, Tyrosine-protein kinase receptor EPH-3, hEK5, Ephrin type-B receptor 2, Tyrosine-protein kinase TYRO5, EK5, HEK5, EPHB2, ELK-related tyrosine kinase, TYRO5, Renal carcinoma antigen NY-REN-47, EPH tyrosine kinase 3, DRT, EPH-like kinase 5
EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1., PMID:40489568
EphB receptors modulate neuropathic pain via Ca2+/calpain/autophagy in spinal cord of mice., PMID:40407305
Calcifying pseudoneoplasm of the neuraxis progressing to G5/PDGFRA subgroup glioblastoma in a United States Army veteran with a history of head trauma and germline POT1 and EPHB2 mutations: illustrative case., PMID:40388884
Inhibiting 5-HT2C receptor in the hippocampus rescues EphB2-dependent memory impairment in mice., PMID:40374059
Regulatory role of neuronal guidance proteins in spinal cord injury., PMID:40364635
Ligand preference of EphB2 receptor is selectively regulated by N-glycosylation., PMID:40330885
EphB2 receptor tyrosine kinase-mediated excitatory synaptic functions are negatively modulated by MDGA2., PMID:40316130
EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV., PMID:40235485
Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas., PMID:40075431
EPHB2 Promotes the Progression of Oral Squamous Cell Carcinoma Cells Through the Activation of VPS4A-Mediated Autophagy., PMID:40017157
Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid., PMID:39972061
Functions and clinical significance of KCNB1 in esophageal squamous cell carcinoma., PMID:39893596
Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma., PMID:39841145
Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through the Vegfa-Ephb2 Pair., PMID:39629971
Identification of differentially expressed genes and polymorphisms related to intramuscular oleic-to-stearic fatty acid ratio in pigs., PMID:39593270
Corrigendum: Activation of EphrinB2/EphB2 signaling in the spine cord alters glia-neuron interactions in mice with visceral hyperalgesia following maternal separation., PMID:39399462
EphB2, EphB4, and ephrin-B1 expression and localization in postnatal developing epididymis in mice., PMID:39390685
Androgen Receptor Promotes Lung Cancer Metastasis by Modifying the miR23a-3p/EPHB2 Pathway., PMID:39390216
EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin Inhibitory Synapse Development., PMID:39327008
Circadian system disorder induced by aberrantly activated EFNB2-EPHB2 axis leads to facilitated liver metastasis in gastric cancer., PMID:39298082
Silencing EPHB2 diminished the malignant biological properties of esophagus cancer cells by blocking autophagy and Wnt/β-catenin pathway., PMID:39291656
Activation of EphrinB2/EphB2 signaling in the spine cord alters glia-neuron interactions in mice with visceral hyperalgesia following maternal separation., PMID:39290870
Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids., PMID:39285481
Comprehensive pan-cancer analysis reveals EPHB2 is a novel predictive biomarker for prognosis and immunotherapy response., PMID:39198775
Cysteine sulfenylation contributes to liver fibrosis via the regulation of EphB2-mediated signaling., PMID:39164267
Impact and Interrelationships of Striatal Proteins, EPHB2, OPRM1, and PER2 on Mild Cognitive Impairment., PMID:39002057
EPHB2 Knockdown Mitigated Myocardial Infarction by Inhibiting MAPK Signaling., PMID:38955672
ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming through EphB2-MNK-eIF4E signaling in both mice and humans., PMID:38925462
EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory., PMID:38913115
Genome-wide association study reveals the candidate genes of humerus quality in laying duck., PMID:38806002
Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release., PMID:38758791
NMDA receptor autoantibodies primarily impair the extrasynaptic compartment., PMID:38758090
Enhanced EphB2-Specific Peptide Inhibitors through Stabilization of Polyproline II Helical Structure., PMID:38739742
The lack of EphB3 receptor prevents bone loss in mouse models of osteoporosis., PMID:38739682
EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis., PMID:38589317
VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain., PMID:38562765
Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis., PMID:38558087
Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis., PMID:38442009
Overexpression of EphB2 in the basolateral amygdala is crucial for inducing visceral pain sensitization in rats subjected to water avoidance stress., PMID:38353051
Prognostic Markers in Tyrosine Kinases Specific to Basal-like 2 Subtype of Triple-Negative Breast Cancer., PMID:38338684
EphB2 promotes enteric nitrergic hyperinnervation and neurogenic inflammation in DSS-induced chronic colitis in mice., PMID:38295544
Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function., PMID:38289221
EPHB2 as a key mediator of glioma progression: Insights from microenvironmental receptor ligand-related prognostic gene signature., PMID:38286348
HOXA3 functions as the on-off switch to regulate the development of hESC-derived third pharyngeal pouch endoderm through EPHB2-mediated Wnt pathway., PMID:38259452
Contrasting Effects of Cancer-Associated Mutations in EphA3 and EphB2 Kinases., PMID:38252844
Whole-genome resequencing of major populations revealed domestication-related genes in yaks., PMID:38233755
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology., PMID:38150042
Interaction between the EPHB2 receptor and EFNB1 ligand drives gastric cancer invasion and metastasis via the Wnt/β-catenin/FAK pathway., PMID:38114003
Effects of miR-204-5p and Target Gene EphB2 on Cognitive Impairment Induced by Aluminum Exposure in Rats., PMID:37985568
The long non-coding RNA TAZ-AS202 promotes lung cancer progression via regulation of the E2F1 transcription factor and activation of Ephrin signaling., PMID:37980331
For research use only. Not for human or drug use.
