Catalog No.
AHD80301
Biological activity
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant human GP88/GRN (Cat #: AHD80301), immobilized at 10-40 μg/mL on a nitrocellulose coated plate, is able to significantly enhance neurite outgrowth.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Thr18-Leu593
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P28799
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B
The antioxidant stress effect of granulin precursor in vitiligo., PMID:40415096
Molecular mechanisms and targeted therapy of progranulin in metabolic diseases., PMID:40290306
Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells., PMID:40234992
A role for astrocytic miR-129-5p in frontotemporal dementia., PMID:40216778
Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection., PMID:40180225
PGRN knockdown alleviates pulmonary fibrosis regulating the Akt/GSK3β signaling pathway., PMID:40088870
A novel c.1468 G > A GRN mutation causes frontotemporal dementia in a Chinese Han family., PMID:40055834
Integrated multiomics analysis highlights the immunosuppressive role of granulin precursor positive macrophages in hepatocellular carcinoma., PMID:39995994
Clinical characteristics of semantic variant of primary progressive aphasia with TDP-43- and tau-related gene variants., PMID:39924821
Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration., PMID:39920674
Progranulin Protects Against Osteoporosis by Regulating Osteoclast and Osteoblast Balance via TNFR Pathway., PMID:39910695
Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer., PMID:39910394
Progranulin measurement with a new automated method: a step forward in the diagnostic approach to neurodegenerative disorders., PMID:39819746
Maternal organokines throughout pregnancy as predictors of neonatal anthropometric characteristics and adiposity., PMID:39698038
PGRN protects against serum deprivation-induced cell death by promoting the ROS scavenger system in cervical cancer., PMID:39695087
Two novel variants in GRN: the relevance of CNV analysis and genetic screening in FTLD patients with a negative family history., PMID:39680222
O-GlcNAcylation of progranulin promotes hepatocellular carcinoma proliferation., PMID:39657353
A new GRN variant in logopenic variant primary progressive aphasia: a case report and literature review., PMID:39632497
Genetics and Neuropathology of Neurodegenerative Dementias., PMID:39620845
The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick collection., PMID:39614734
Association of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia., PMID:39527773
Association of Initial Side of Brain Atrophy With Clinical Features and Disease Progression in Patients With GRN Frontotemporal Dementia., PMID:39527772
Elevated plasma progranulin levels in the acute phase are correlated with recovery of left ventricular function in the chronic phase in patients with acute myocardial infarction., PMID:39514465
Progranulin-dependent repair function of regulatory T cells drives bone-fracture healing., PMID:39509336
Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review., PMID:39500348
Correction: Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin., PMID:39352802
Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons., PMID:39340829
Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia., PMID:39284109
Sortilin is associated with progranulin deficiency and autism-like behaviors in valproic acid-induced autism rats., PMID:39218796
An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation., PMID:39185427
Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia - A GENFI study., PMID:39153518
Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells., PMID:39145305
The role of progranulin in macrophages of a glioblastoma model., PMID:39141257
Long Non-Coding RNA Profile in Genetic Symptomatic and Presymptomatic Frontotemporal Dementia: A GENFI Study., PMID:39121124
Plasma Kallistatin and Progranulin as Predictive Biomarkers of Intraamniotic Inflammation, Microbial Invasion of the Amniotic Cavity, and Composite Neonatal Morbidity/Mortality in Women With Preterm Premature Rupture of Membranes., PMID:39072836
Progranulin and Vaspin as Potential Novel Markers in the Etiology of Type 1 Diabetes in Children., PMID:39064594
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency., PMID:39033178
Progranulin, sICAM-1, and sVCAM-1 May Predict an Increased Risk for Ventricular Arrhythmias in Patients with Systemic Sclerosis., PMID:39000486
Mutational Landscape of Alzheimer's Disease and Frontotemporal Dementia: Regional Variances in Northern, Central, and Southern Italy., PMID:39000146
Tear Fluid Progranulin as a Noninvasive Biomarker for the Monitoring of Corneal Innervation Changes in Patients With Type 2 Diabetes Mellitus., PMID:38984913
Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection., PMID:38936554
Neurofilaments and progranulin are related to atrophy in frontotemporal lobar degeneration - A transdiagnostic study cross-validating atrophy and fluid biomarkers., PMID:38865340
Frequency of C9orf72, GRN, and MAPT pathogenic variants in patients recruited at the Belgrade Memory Center., PMID:38847891
GRN knockdown regulates the expression and alternative splicing of genes associated with aphasia-related diseases in PC12 cells., PMID:38823507
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results., PMID:38745011
An autopsy case of type A FTLD-TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently., PMID:38715398
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis., PMID:38689292
A systematic review of progranulin concentrations in biofluids in over 7,000 people-assessing the pathogenicity of GRN mutations and other influencing factors., PMID:38539243
Progranulin and neuropathological features of Alzheimer's disease: longitudinal study., PMID:38441695
Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons., PMID:38415376
For research use only. Not for human or drug use.
