Catalog No.
AHD23001
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant IFNAR1 (Cat #: AHD23001) is present at 10 μg/mL, it binds to recombinant human IFNAR2 in the presence of recombinant human IFN alpha 2. The concentration of recombinant human IFNAR2 that produces 50% of the optimal binding response is approximately 0.5-1.5 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Lys28-Lys436
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P17181
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1
Heat shock protein 90 chaperone activity is required for hepatitis A virus replication., PMID:40470959
Trem2 regulates microglial migratory responses via type I interferon signaling during photoreceptor degeneration., PMID:40468324
Heterozygous interferon signaling deficient mice as animal models for Chikungunya virus infection in the heart., PMID:40410198
Regulation of Immune-Related Gene Expression by Salinity-Induced HPI Axis in Large Yellow Croaker, Larimichthys crocea., PMID:40362534
Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition., PMID:40307881
Evolution of Zika virus in Rag1-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitness., PMID:40291117
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling., PMID:40286790
Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling., PMID:40260261
A novel approach using IFNAR1 KO mice for assessing Akabane virus pathogenicity and vaccine efficacy., PMID:40209629
Identification of key factors causing ketosis in dairy cows with low feed intake., PMID:40184169
Unravelling Cancer Immunity: Coagulation.Sig and BIRC2 as Predictive Immunotherapeutic Architects., PMID:40159652
Bordetella pertussis infection activates the type I interferon signaling pathway to exacerbate respiratory tract inflammatory response., PMID:40124358
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design., PMID:40111224
A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation., PMID:40101721
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling., PMID:40097626
Virus-like particle vaccine with authentic quaternary epitopes protects against Zika virus-induced viremia and testicular damage., PMID:40013767
Sustained Interferon Signature Suppression With Anifrolumab in a Patient With STING-Associated Vasculopathy with Onset in Infancy Refractory to JAK Inhibitor and Dazukibart Therapy., PMID:40007227
Influenza virus-induced type I interferons disrupt alveolar epithelial repair and tight junction integrity in the developing lung., PMID:39984053
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation., PMID:39947179
Establishment of a Panel of Human Cell Lines to Identify Cellular Receptors Used by Enteroviruses to Infect Cells., PMID:39940693
Pair combinations of human monoclonal antibodies fully protected mice against bunyavirus SFTSV lethal challenge., PMID:39888973
Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade., PMID:39885296
Characterizing the diabetes-induced pathological changes of the mouse lung by single-cell RNA sequencing., PMID:39832739
Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats., PMID:39823736
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis., PMID:39819503
The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity., PMID:39819005
Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection., PMID:39803443
Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection., PMID:39772237
Gut TLRs and IFN pathways mRNA expression and frequencies of CD4+T cell expressing CD38 or HLA-DR go in parallel during HIV immunopathogenesis., PMID:39765313
SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors., PMID:39713296
A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity., PMID:39680367
ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication., PMID:39679197
Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in systemic lupus erythematosus., PMID:39656824
IFN-I promotes T-cell-independent immunity and RBC autoantibodies via modulation of B-1 cell subsets in murine SCD., PMID:39656114
TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages., PMID:39652608
Association study of the JAK/STAT signaling pathway with susceptibility to COVID-19 in moroccan patient and in-silico analysis of rare variants., PMID:39647533
Expression of Toll-like Receptor Genes and Antiviral Cytokines in Macrophage-like Cells in Response to Indole-3-carboxylic Acid Derivative., PMID:39599833
Genetic defects of brain immunity in childhood herpes simplex encephalitis., PMID:39567785
miRNA-431-5p enriched in EVs derived from IFN-β stimulated MSCs potently inhibited ZIKV through CD95 downregulation., PMID:39563434
Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy., PMID:39561221
Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8+ T cell responses against an arthritogenic alphavirus., PMID:39535221
Vaccine candidates based on MVA viral vectors expressing VP2 or VP7 confer full protection against Epizootic hemorrhagic disease virus in IFNAR(-/-) mice., PMID:39508577
Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy., PMID:39469633
TGFB2 mRNA Levels Prognostically Interact with Interferon-Alpha Receptor Activation of IRF9 and IFI27, and an Immune Checkpoint LGALS9 to Impact Overall Survival in Pancreatic Ductal Adenocarcinoma., PMID:39457004
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament., PMID:39441507
Normalized Interferon Signatures and Clinical Improvements by IFNAR1 Blocking Antibody (Anifrolumab) in Patients with Type I Interferonopathies., PMID:39441221
RT-qPCR Analysis of Inflammatory & Apoptotic Factors-Related Gene Expression in ZIKV-Infected IFNAR1-/- Mice., PMID:39432111
pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection., PMID:39405340
[Translated article] Use of Anifrolumab in Systemic Lupus Erythematosus, Cutaneous Lupus Erythematosus, and Other Autoimmune Dermatoses., PMID:39389344
Genetic analyses of a large consanguineous south Indian family reveal novel variants in NAGPA and four hitherto unreported genes in developmental stuttering., PMID:39382170
For research use only. Not for human or drug use.
