Catalog No.
AHD10001
Biological activity
Measured by its ability to transfer galactose from UDPgalactose to NAcetyl-alpha -Dglucosamine. The specific activity is >2,000 pmol/min/μg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly44-Ser398
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P15291
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
B4GALT1, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1, GGTB2, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Beta-1,4-GalTase 1, Neolactotriaosylceramide beta-1,4-galactosyltransferase, N-acetyllactosamine synthase, Lactose synthase A protein, Beta4Gal-T1, Beta-1,4-galactosyltransferase 1, b4Gal-T1, Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase, Nal synthase, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
Cytosolic UDP-Gal biosynthetic machinery is required for dimerization of SLC35A2 in the Golgi membrane and its interaction with B4GalT1., PMID:40230451
SPOP/NOLC1/B4GALT1 signaling axis enhances paclitaxel resistance in endometrial cancer by inducing O-dysglycosylation., PMID:40097806
Sequential Proteomic and N-Glycoproteomic Analyses of Bronchoalveolar Lavage Fluids for Potential Biomarker Discovery of Lung Adenocarcinoma., PMID:39869828
Glycosylation Pathways Targeted by Deregulated miRNAs in Autism Spectrum Disorder., PMID:39859496
Molecular tag for promoting N-glycan maturation in the cargo receptor-mediated secretion pathway., PMID:39717080
Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid., PMID:39342078
Integrated proteomic and glycoproteomic analysis reveals heterogeneity and molecular signatures of brain metastases from lung adenocarcinomas., PMID:39341452
Regulation of gene expression in milk secretory pathways during secretory activation in Holstein cows., PMID:39245162
β-1,4-Galactosyltransferase 1 protects against cerebral ischemia injury in mice by suppressing ferroptosis via the TAZ/Nrf2/HO-1 signaling pathway., PMID:39233353
B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis., PMID:39231945
The genetics and epidemiology of N- and O-immunoglobulin A glycomics., PMID:39123268
Delving into human α1,4-galactosyltransferase acceptor specificity: The role of enzyme dimerization., PMID:39111055
Heterologous expression of a novel galactose-1-phosphate uridylyltransferase from Thermodesulfatator indicus and its application for bioproduction of Gal-β-1,4-GlcNAc-X., PMID:38950762
Altered N-linked glycosylation in depression: A pre-clinical study., PMID:38801920
Suborganellar resolution imaging for the localisation of human glycosylation enzymes in tobacco Golgi bodies., PMID:38687244
Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma., PMID:38608280
Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization., PMID:38515381
Glyco-Engineering Cell Surfaces by Exo-Enzymatic Installation of GlcNAz and LacNAz Motifs., PMID:38394345
Characterization of galactosyltransferase and sialyltransferase genes mediating the elongation of the extracellular O-GlcNAc glycans., PMID:38359610
Downregulation of long noncoding RNA B4GALT1-AS1 is associated with breast cancer development., PMID:38326326
Intracellular polyamine depletion induces N-linked galactosylation of the monoclonal antibody produced by CHO DP-12 cells., PMID:37922995
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway., PMID:37907465
Serum IgA augments adhesiveness of cultured lung microvascular endothelial cells and suppresses angiogenesis., PMID:37741001
Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition., PMID:37627310
In-Depth Mass Spectrometry Analysis Reveals the Plasma Proteomic and N-Glycoproteomic Impact of an Amish-Enriched Cardioprotective Variant in B4GALT1., PMID:37328064
B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma., PMID:37303063
Development and nationwide validation of kidney graft injury markers using urinary exosomes and microvesicles (complete English translation of the Japanese version)., PMID:37280521
Analysis of the Interaction of UBE2Q1 with B4GALT1 and P53: Experimental and Molecular Modeling Study., PMID:37198983
Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer's disease., PMID:37188790
High expression of B4GALT1 is associated with poor prognosis in acute myeloid leukemia., PMID:36568388
B4GALT1 as a New Biomarker of Idiopathic Pulmonary Fibrosis., PMID:36499368
Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation., PMID:36454514
B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice., PMID:36084919
Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer., PMID:35538152
Identification of Key microRNAs in Diabetes Mellitus Erectile Dysfunction Rats with Stem Cell Therapy by Bioinformatic Analysis of Deep Sequencing Data., PMID:35021304
Investigation of gene expression and genetic simultaneous control associated with erectile dysfunction and diabetes., PMID:34933709
Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen., PMID:34855475
Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling., PMID:34326372
Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans., PMID:34155258
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program., PMID:33568819
Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells., PMID:33549674
Identification of novel single-nucleotide polymorphism at exon1 and 2 region of B4GALT1 gene and its association with milk production traits in crossbred cattle of Kerala, India., PMID:33427026
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110., PMID:33309857
B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo., PMID:33287670
Increased B4GALT1 expression is associated with platelet surface galactosylation and thrombopoietin plasma levels in MPNs., PMID:33238000
Identification of key genes in osteoarthritis using bioinformatics, principal component analysis and meta-analysis., PMID:33235627
Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans., PMID:33171474
Fenugreek Stimulates the Expression of Genes Involved in Milk Synthesis and Milk Flow through Modulation of Insulin/GH/IGF-1 Axis and Oxytocin Secretion., PMID:33081164
The AKR1C3/AR-V7 complex maintains CRPC tumour growth by repressing B4GALT1 expression., PMID:32902124
Apolipoprotein C-III O-glycoform profiling of 500 serum samples by matrix-assisted laser desorption/ionization mass spectrometry for diagnosis of congenital disorders of glycosylation., PMID:32677746
For research use only. Not for human or drug use.
