Catalog No.
AHD03001
Biological activity
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-DpaAR-NH2. The specific activity is >1,500 pmol/min/µg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln18-Pro396
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P14091
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CTSE, Cathepsin E
CTSE inhibits anti-tumor T cell response by promoting des-γ-carboxy prothrombin releasing in hepatocellular carcinoma., PMID:40467555
Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer., PMID:40057469
Assessing the Causal Relationship Between Plasma Proteins and Pulmonary Fibrosis: A Systematic Analysis Based on Mendelian Randomization., PMID:40001968
Integrative multi-omics and machine learning identify a robust signature for discriminating prognosis and therapeutic targets in bladder cancer., PMID:39991573
Shaoyao decoction alleviates DSS-induced colitis by inhibiting IL-17a-mediated polarization of M1 macrophages., PMID:39427735
Machine learning identifies SLC6A14 as a novel biomarker promoting the proliferation and metastasis of pancreatic cancer via Wnt/β-catenin signaling., PMID:38267509
Novel insights into the nervous system affected by prolonged hyperglycemia., PMID:37462767
FVB/N mouse strain regulatory T cells differ in phenotype and function from the C57BL/6 and BALB/C strains., PMID:36238362
Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies., PMID:36175412
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease., PMID:35181976
Construction of miRNA-mRNA-TF Regulatory Network for Diagnosis of Gastric Cancer., PMID:34840985
Dynamic Urinary Proteome Changes in Ovalbumin-Induced Asthma Mouse Model Using Data-Independent Acquisition Proteomics., PMID:34785909
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations., PMID:34741638
Natural Compounds from Hatikana Extract Potentiate Antidiabetic Actions as Displayed by In Vivo Assays and Verified by Network Pharmacological Tools., PMID:34725640
Gene Expression Profiles Associated with Radio-Responsiveness in Locally Advanced Rectal Cancer., PMID:34205090
TSPAN1, TMPRSS4, SDR16C5, and CTSE as Novel Panel for Pancreatic Cancer: A Bioinformatics Analysis and Experiments Validation., PMID:33815409
A TP53-Associated Immune Prognostic Signature for the Prediction of Overall Survival and Therapeutic Responses in Muscle-Invasive Bladder Cancer., PMID:33391264
Identification and validation of an immune-related gene-based prognostic index for bladder cancer., PMID:33042413
Pathogenic infection and immune-related gene expression of Chinese sturgeon (Acipenser sinensis) challenged by Citrobacter freundii., PMID:32949686
Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network., PMID:32537471
Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D., PMID:32446374
First report of cathepsin E in a teleost (Korean rose bitterling, Rhodeus uyekii): Molecular characterisation and tissue distribution., PMID:31904433
Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer., PMID:31195060
Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis., PMID:31095099
Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells., PMID:30816218
Exploring and comparing of the gene expression and methylation differences between lung adenocarcinoma and squamous cell carcinoma., PMID:30317601
The Relationship between the Concentration of Cathepsin A, D, and E and the Concentration of Copper and Zinc, and the Size of the Aneurysmal Enlargement in the Wall of the Abdominal Aortic Aneurysm., PMID:30278264
Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer., PMID:30089113
PPARα-Target Gene Expression Requires TIS21/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition., PMID:29385670
Combination of active targeting, enzyme-triggered release and fluorescent dye into gold nanoclusters for endomicroscopy-guided photothermal/photodynamic therapy to pancreatic ductal adenocarcinoma., PMID:28582716
rHuKGF ameliorates protease/anti-protease imbalance in emphysematous mice., PMID:28552795
Cathepsin E Deficiency Ameliorates Graft-versus-Host Disease and Modifies Dendritic Cell Motility., PMID:28298913
Environmental enrichment attenuates the blood brain barrier dysfunction induced by the neonatal hypoxia-ischemia., PMID:27326908
Protective effects of a Chotosan Fraction and its active components on β-amyloid-induced neurotoxicity., PMID:26876445
Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210., PMID:26226952
Unstable Foxp3+ regulatory T cells and altered dendritic cells are associated with lipopolysaccharide-induced fetal loss in pregnant interleukin 10-deficient mice., PMID:26224007
Gastric-type expression signature in serrated pathway-associated colorectal tumors., PMID:25704805
Environmental stimulation improves performance in the ox-maze task and recovers Na+,K+-ATPase activity in the hippocampus of hypoxic-ischemic rats., PMID:25617656
Characterization and localization of the Campylobacter jejuni transformation system proteins CtsE, CtsP, and CtsX., PMID:25448813
High Expression of Cathepsin E in Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma., PMID:25348778
Cathepsin E promotes pulmonary emphysema via mitochondrial fission., PMID:25239563
A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis., PMID:25029475
Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet., PMID:24583126
Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage., PMID:24464956
Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP., PMID:24418614
Cathepsin E deficiency impairs autophagic proteolysis in macrophages., PMID:24340026
Allergic airway inflammation in mice deficient for the antigen-processing protease cathepsin E., PMID:22846634
[Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats]., PMID:22730688
Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice., PMID:22449997
Cathepsin E, maspin, Plk1, and survivin are promising prognostic protein markers for progression in non-muscle invasive bladder cancer., PMID:22449953