Catalog No.
AHC93501
Biological activity
Immobilized recombinant CD32A/FCGR2A (Cat #: AHC93501) at 1 μg/mL (100 μL/well) can bind biotinylated human IgG1 with a linear range of 30-250 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala36-Ile218 (R167)
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P12318
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fc-gamma RII-a, IgG Fc receptor II-a, IGFR2, FCG2, CDw32, FCGR2A1, FCGR2A, FcRII-a, CD32, Low affinity immunoglobulin gamma Fc region receptor II-a, Fc-gamma-RIIa
Human Fcγ-receptors selectively respond to C-reactive protein isoforms., PMID:40458392
FCGR2A Gene Polymorphism Association in Children with Multisystem Inflammatory Syndrome., PMID:40214943
Identification of biomarkers associated with phagocytosis regulatory factors in coronary artery disease using machine learning and network analysis., PMID:39953122
Structural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia., PMID:39933652
Roles of immunoglobulin GM and KM allotypes and Fcγ receptor 2 A genotypes in humoral immunity to a conserved microbial polysaccharide in pulmonary diseases., PMID:39774260
FcRγIIA attenuates pathology of cutaneous leishmaniasis and modulates ITAMa/i balance., PMID:39696675
Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19., PMID:39415081
Calcitonin gene-related peptide promotes epithelial reparative and anticolitic functions of IL-4 educated human macrophages., PMID:39378308
FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms., PMID:39359734
Genetic variants in FCGR2A, PTPN2, VDR as predictive signatures of aggressive phenotypes in cerebral cavernous malformation., PMID:39236970
Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors., PMID:39152765
Correlations of FCGR2A 131R/H and FCGR3A 158V/F Polymorphisms with the Susceptibility of Peri-implantitis in Chinese Han Population., PMID:38771420
Druggability properties of a L309K mutation in the antibody CH2 domain., PMID:38742229
Immunoglobulin genes and severity of COVID-19., PMID:38602517
Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration., PMID:38544414
Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro., PMID:38455048
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the molecular feature of M2 macrophages of head and neck squamous cell carcinoma., PMID:38393307
Distinct effector functions mediated by Fc regions of bovine IgG subclasses and their interaction with Fc gamma receptors., PMID:38077405
Relationship Between Human FCγRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants., PMID:38029355
AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery., PMID:37992599
Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia., PMID:37872381
Differential FCGR2A and FCGR3A Alleles/Genotypes in Pemphigus Vulgaris and Pemphigus Foliaceus in Southeastern Brazil., PMID:37806444
Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes., PMID:37790943
Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology., PMID:37703311
Downregulated APOD and FCGR2A correlates with immune infiltration and lipid-induced symptoms of irritable bowel syndrome., PMID:37648784
FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab., PMID:37575254
T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity., PMID:37436890
Antimyeloperoxidase antibodies modulate inflammatory responses and activate profibrotic pathways in human monocytes., PMID:37331172
Vaccine-induced immune thrombotic thrombocytopenia: what do we know hitherto?, PMID:37261122
Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis., PMID:37174624
Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis., PMID:37149714
Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis., PMID:37114884
FcγRIIA-specific DARPins as novel tools in blood cell analysis and platelet aggregation., PMID:37100283
Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype., PMID:37029410
Mass cytometry for the multiplexed quantification and characterization of target expression on circulating cells in whole blood., PMID:36966446
FCGR2A as one novel potential target for poor survival prognosis of clear cell renal cell carcinoma., PMID:36930102
Impact of FCGR2A R131H, FCGR3A F158V and FCGR3B NA1/NA2 polymorphisms on response to Fc-containing TNF inhibitors in Tunisian rheumatoid arthritis patients., PMID:36919284
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice., PMID:36116152
Cell-based reporter assays for measurements of antibody-mediated cellular cytotoxicity and phagocytosis against SARS-CoV-2 spike protein., PMID:35671888
Local Innate Markers and Vaginal Microbiota Composition Are Influenced by Hormonal Cycle Phases., PMID:35401577
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19., PMID:35309299
SAR442085, a novel anti-CD38 antibody with enhanced antitumor activity against multiple myeloma., PMID:35201323
The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients., PMID:35149195
Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton's Tyrosine Kinase., PMID:35008508
ACE2 can act as the secondary receptor in the FcγR-dependent ADE of SARS-CoV-2 infection., PMID:35005526
Role of Fcγ receptors in HER2-targeted breast cancer therapy., PMID:34992090
Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease., PMID:34970970
Genetic polymorphisms of FCGR2A, ORAI1 and CD40 are associated with risk of lung cancer., PMID:34871197
Fc fragment of immunoglobulin G receptor IIa (FCGR2A) as a new potential prognostic biomarker of esophageal squamous cell carcinoma., PMID:34743150
An Afucosylated Anti-CD32b Monoclonal Antibody Induced Platelet-Mediated Adverse Events in a Human Fcγ Receptor Transgenic Mouse Model and Its Potential Human Translatability., PMID:34687301
For research use only. Not for human or drug use.
