Catalog No.
AHC84101
Biological activity
Measured by its ability to induce clustering of human clear cell carcinoma epithelial cells (Caki‑2).
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
α chain [Ser228-Glu449] & β chain [Asp23-Arg227]
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P10909
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APOJ, ApoJalpha, NA1/NA2, Complement cytolysis inhibitor, Complement cytolysis inhibitor a chain, Ku70-binding protein 1, Testosterone-repressed prostate message 2, ApoJbeta, TRPM-2, Complement cytolysis inhibitor b chain, SGP-2, KUB1, Apolipoprotein J, Apo-J, Clusterin, Sulfated glycoprotein 2, Aging-associated gene 4 protein, CLI, CLU, Complement-associated protein SP-40,40
Proliferative arrest induces neuronal differentiation and innate immune responses in normal and Creutzfeldt-Jakob Disease agent (CJ) infected rat septal neurons., PMID:40434970
Prognostic Value of Urinary Biomarkers in Proteinuria Progression in IgA Nephropathy Patients Treated with Budesonide., PMID:40428765
Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction., PMID:40418078
S6K1 overexpression enhances autophagy in breast cancer cells by inducing the translation of CLU., PMID:40405358
The genetic risk factors, molecular pathways, microRNAs, and the gut microbiome in Alzheimer's disease., PMID:40374065
Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils., PMID:40355981
Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation., PMID:40337510
Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences., PMID:40336141
Association of Alzheimer's-Related Gene Variants with Autism Spectrum Disorder: A Case-Control Study in an Iraqi Cohort., PMID:40327194
Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer's disease mice., PMID:40322539
Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication., PMID:40319306
CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density., PMID:40311610
Drosophila Clu ribonucleoprotein particle dynamics rely on the availability of functional Clu and translating ribosomes., PMID:40302698
Nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton regulate spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes., PMID:40247324
Loosening the Lid on Shoulder Osteoarthritis: How the Transcriptome and Metabolic Syndrome Correlate with End-Stage Disease., PMID:40243895
Transcriptomic analysis reveals distinct molecular signatures and regulatory networks of osteoarthritic chondrocytes versus mesenchymal stem cells during chondrogenesis., PMID:40242907
Clusterin activates the heat shock response via the PI3K/Akt pathway to protect cardiomyocytes from high-temperature-induced apoptosis., PMID:40177418
Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and Pathways for Alzheimer's Disease., PMID:40166037
Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins., PMID:40164870
The relationship between Alzheimer's disease and intracerebral hemorrhage based on Mendelian randomization., PMID:40151895
Different Proteostasis Mechanisms Facilitate the Assembly of Individual Components on the Chitin Synthase 3 Complex at the Endoplasmic Reticulum., PMID:40137259
Aboveground whole-plant live imaging method for nitric oxide (NO) reveals an intricate relationship between NO and H2O2., PMID:40135542
Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan., PMID:40132120
Interrogating mediators of single-cell transcriptional changes in the acute damaged cerebral cortex: Insights into endothelial-astrocyte interactions., PMID:40090391
Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis., PMID:40059777
Enhanced social interaction protects cognition by preserving synapse numbers., PMID:40057101
Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts., PMID:40033301
Clusterin: structure, function and roles in disease., PMID:39991767
Clusterin inhibits lipopolysaccharide induced liver injury., PMID:39966409
Brain and plasmatic CLUSTERIN are translational markers of Alzheimer's disease., PMID:39965636
Spontaneous Self-Organized Order Emerging From Intrinsically Disordered Protein Polymers., PMID:39950263
The Expression of Neuroendocrine Markers in a Small Subset of Ameloblastoma with Implications of Clusterin., PMID:39937015
Neurodegeneration in Autism: A Study of Clusterin, Very Long-Chain Fatty Acids, and Carnitine., PMID:39932645
The secreted host-cell protein clusterin interacts with PmpD and promotes Chlamydia trachomatis infection., PMID:39931630
Assessing the Adjuvant Potential of Chinese Hamster Ovary Host Cell Proteins Using an In Vitro Dendritic Cell Assay., PMID:39930890
Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU., PMID:39905539
Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis., PMID:39877352
Establishment and evaluation of rabbit model for corneal ectasia by photorefractive keratectomy., PMID:39862961
The Platelet-Specific Gene Signature in the Immunoglobulin G4-Related Disease Transcriptome., PMID:39859144
Binding and cleavage of pro-urokinase by a tegument extract of Fasciola hepatica newly excysted juveniles activate the host fibrinolytic system., PMID:39856784
Activation of autophagy with PF-06409577 alleviates heatstroke-induced organ injury., PMID:39855028
Investigation of the Anticarcinogenic Effects of Hypericum perforatum Extract on Human Thyroid Cancer., PMID:39817392
(-)-Epigallocatechin-3-gallate promotes the dermal papilla cell proliferation and migration through the induction of VEGFA., PMID:39814186
Targeting immune checkpoints on myeloid cells: current status and future directions., PMID:39751898
A non-invasive model for diagnosis of primary Sjogren's disease based on salivary biomarkers, serum autoantibodies, and Schirmer's test., PMID:39695856
Apolipoprotein (APOA1, APOE, CLU) genes expression in the CA3 region of the hippocampus in an ischemic model of Alzheimer's disease with survival up to 2 years., PMID:39686609
Glycosylation Pattern of Serum Clusterin in Psoriatic Arthritis and Rheumatoid Arthritis-The Search for New Diagnostic Glycomarkers., PMID:39684771
IGHG4: innovative diagnostic biomarkers for iron overload in β-thalassemia patients., PMID:39676317
Regulation of Clusterin in the Heart and Plasma of Mice After Transverse Aortic Constriction., PMID:39671261
Clusterin mediates hydroquinone-induced cytotoxic responses in HL-60 differentiated cells., PMID:39638872
For research use only. Not for human or drug use.
