Catalog No.
AMC96801
Biological activity
Measured in a cell proliferation assay using antibody against CD3-activated human peripheral blood mononuclear cell (PBMC). The ED50 for this effect is typically 0.4-4 ng/mL.
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Glu26-Ile154
Nature
Recombinant
Endotoxin level
<1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P10168
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-7, Interleukin-7, IL7,
Dose Optimization of rhIL-7-hyFc for Patients With Lymphopenia Using a Neonatal Fc Receptor-Mediated Recycling-Based and Target-Mediated Drug Disposition Pharmacokinetic Model., PMID:40396986
Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer., PMID:40374882
IL-7 in autoimmune diseases: mechanisms and therapeutic potential., PMID:40313966
Endogenous IL-7 Variation in Relation to Lymphocyte Subtypes in Septic Patients., PMID:40005375
A randomized, double-blind, placebo-controlled trial of IL-7 in critically ill patients with COVID-19., PMID:39903535
IL-7 secreted by keratinocytes induces melanogenesis via c-kit/MAPK signaling pathway in Melan-a melanocytes., PMID:39825949
Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma., PMID:39776916
The Role of PD-1/PD-L1 and IL-7 in Lymphocyte Dynamics and Sepsis Progression: A Biomarker Study in Critically Ill Patients., PMID:39684323
IL7 as a Risk Factor for Prostate Cancer: Implications for T Cell Apoptosis and Infiltration in the Tumor Microenvironment., PMID:39593187
A Phase II Open-Label, Randomized Clinical Trial of Atezolizumab with or without Human Recombinant IL-7 (CYT107) in Advanced Urothelial Cancer., PMID:39576210
A novel strategy of co-expressing CXCR5 and IL-7 enhances CAR-T cell effectiveness in osteosarcoma., PMID:39450160
Membrane-bound IL-7 immobilized by the CD8 transmembrane region improves efficacy of CD19 CAR-T cell therapy., PMID:39443955
IL-7-dependent and -independent lineages of IL-7R-dependent human T cells., PMID:39352394
IL-4, IL-7, IL-9, NT, NRP1 May Be Useful Markers in the Diagnosis of Endometrial Cancer., PMID:39334861
Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer., PMID:39240078
Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain., PMID:39186002
An IL-7 fusion protein targeting EDA fibronectin upregulates TCF1 on CD8+ T-cells, preferentially accumulates to neoplastic lesions, and boosts PD-1 blockade., PMID:39142716
APOE ε4-associated downregulation of the IL-7/IL-7R pathway in effector memory T cells: Implications for Alzheimer's disease., PMID:39129310
Concentration of IL-1β, IL-7, IL-12, IL-17, CX3CL1, ITAC and relation with the seizure severity and sudden unexpected death in epilepsy patient., PMID:39096615
Interleukin-7 expression by CAR-T cells improves CAR-T cell survival and efficacy in chordoma., PMID:39093440
Interleukin-7 Risk Allele, Lymphocyte Counts, and Autoantibodies for Prediction of Risk of Immune-Related Adverse Events in Patients Receiving Atezolizumab plus Bevacizumab Therapy for Unresectable Hepatocellular Carcinoma., PMID:39079513
rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors., PMID:39043602
Expression pattern of serum interleukin-7 in elderly septic patients and its prognostic value for predicting short-term mortality., PMID:38795605
IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy., PMID:38744277
High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome., PMID:38114349
PELI2 regulates early B-cell progenitor differentiation and related leukemia via the IL-7R expression., PMID:38058209
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells., PMID:38033053
The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review., PMID:37566474
IL-7 germline variant: setting the stage for immune-related adverse events., PMID:36748568
In patients with primary Sjögren's syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells., PMID:36505431
IL-7 and IL-7R in health and disease: An update through COVID times., PMID:36503870
IL-7/IL7R axis dysfunction in adults with severe community-acquired pneumonia (CAP): a cross-sectional study., PMID:35907923
The role of interleukin‑7 serum level as biological marker in breast cancer: a cross‑sectional, observational, and analytical study., PMID:35794603
Association between IL-7 and primary Sjögren's syndrome: A single-center study and a systematic scoping review., PMID:35405597
Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes - Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features., PMID:35063672
Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation., PMID:35015072
CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases., PMID:35015026
Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection., PMID:34997007
The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines., PMID:34956167
Immunological effects of dimethyl fumarate treatment in blood and CSF of patients with primary progressive MS., PMID:34739914
Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes., PMID:34625948
IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant., PMID:34603318
Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis., PMID:34596812
IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)., PMID:34452927
TGF-β/IL-7 Chimeric Switch Receptor-Expressing CAR-T Cells Inhibit Recurrence of CD19-Positive B Cell Lymphoma., PMID:34445415
Identification of new IL-7Rα small-molecule agonists: a multi-computational approach., PMID:34431428
Recombinant Mycobacterium smegmatis delivering a fusion protein of human macrophage migration inhibitory factor (MIF) and IL-7 exerts an anticancer effect by inducing an immune response against MIF in a tumor-bearing mouse model., PMID:34389619
IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin., PMID:34325726
Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases., PMID:34276694
Expression Level and Significance of Tim-3 in CD4+ T Lymphocytes in Peripheral Blood of Patients with Coronary Heart Disease., PMID:34236813
For research use only. Not for human or drug use.
