Catalog No.
AHC22601
Biological activity
Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The IC50 value is <2 nM, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Lys397
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P07093
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SERPINE2, Protease nexin I, Protease nexin 1, GDN, Glia-derived nexin, PN-1, Serpin E2, Peptidase inhibitor 7, PI7, PN1, PI-7
H3K9me3 Involved in FOXL2 Regulation of SerpinE2 Expression to Affect Steroid Hormone Synthesis in Follicular Granulosa Cells., PMID:40512073
SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression., PMID:40463876
Potential therapeutic targets for deep vein thrombosis: A proteome-wide Mendelian randomization study., PMID:40462713
Identifying Key Plasma Proteins in the Onset of Parkinson's Disease: Proteome-Wide Mendelian Randomization and Single-Cell RNA Sequencing Analysis., PMID:40380075
Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice., PMID:40323694
Histological signatures map anti-fibrotic factors in mouse and human lungs., PMID:40108456
Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea., PMID:40091489
METTL3 stabilizes SERPINE2 via the m6A modification to drive the malignant progression of gastric signet ring cell carcinoma., PMID:39974426
Five-Gene Expression Signature Associated With Acquired FOLFIRI Resistance and Survival in Metastatic Colorectal Cancer., PMID:39954853
(-)-Epigallocatechin-3-gallate promotes the dermal papilla cell proliferation and migration through the induction of VEGFA., PMID:39814186
Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway., PMID:39754051
CUL4B protects kidneys from acute injury by restraining p53/PAI-1 signaling., PMID:39695153
Integrative transcriptome analysis reveals Serpine2 promotes glomerular mesangial cell proliferation and extracellular matrix accumulation via activating ERK1/2 signalling pathway in diabetic nephropathy., PMID:39557806
PAI-1 influences and curcumin destabilizes MMP-2, MMP-9 and basement membrane proteins during lung injury and fibrosis., PMID:39549545
Identification of Potential Biomarkers and Therapeutic Targets for Periodontitis., PMID:39532570
Alterations in the placental proteome in association with the presence of black carbon particles: A discovery study., PMID:39442658
Identification of key genes and pathways involved in T-DM1-resistance in OE-19 esophageal cancer cells through bioinformatics analysis., PMID:39309859
Serine protease inhibitor E2 protects against cartilage tissue destruction and inflammation in osteoarthritis by targeting NF-κB signalling., PMID:39180420
Senescence-related genes and proteins in the development of Alzheimer's disease: evidence from transcriptomic and Mendelian randomization analysis., PMID:39156738
Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia., PMID:39119725
Comparative analysis of dynamic transcriptomes reveals specific COVID-19 features and pathogenesis of immunocompromised populations., PMID:38752789
Restoring BARX2 in OSCC reverses partial EMT and suppresses metastasis through miR-186-5p/miR-378a-3p-dependent SERPINE2 inhibition., PMID:38719950
A high-cholesterol diet promotes the intravasation of breast tumor cells through an LDL-LDLR axis., PMID:38658568
Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration., PMID:38634469
Biochemical profiling of the follicular environment to predict oocyte competence in cattle., PMID:38466703
SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation., PMID:38407942
Integrating artificial intelligence in osteosarcoma prognosis: the prognostic significance of SERPINE2 and CPT1B biomarkers., PMID:38383657
Identification of Fibroinflammatory and Fibrotic Transcriptomic Subsets of Human Cutaneous Sclerotic Chronic Graft-Versus-Host Disease., PMID:38357212
Identification of renal ischemia reperfusion injury-characteristic genes, pathways and immunological micro-environment features through bioinformatics approaches., PMID:38329418
Serpin peptidase inhibitor, clade E, member 2 is associated with malignant progression and clinical prognosis in oral squamous cell carcinoma., PMID:38303830
Identification of Senescence-Associated Biomarkers in Diabetic Glomerulopathy Using Integrated Bioinformatics Analysis., PMID:38292407
Transcriptomic signature of luteinized cumulus cells of oocytes developing to live birth after women received intracytoplasmic sperm injection., PMID:38036000
Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042
Microdissection of cancer-associated fibroblast infiltration subtypes unveils the secreted SERPINE2 contributing to immunosuppressive microenvironment and immuotherapeutic resistance in gastric cancer: A large-scale study integrating bulk and single-cell transcriptome profiling., PMID:37729702
Anti-inflammatory, Anti-fibrotic and Pro-cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR-1 and miR-199a on Human Cardiac Fibroblasts., PMID:37700183
Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data., PMID:37564980
Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development., PMID:37537391
Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes., PMID:37348749
Metabolomic signature and molecular profile of normal and degenerated human intervertebral disc cells., PMID:37339697
Machine learning modeling and prognostic value analysis of invasion-related genes in cutaneous melanoma., PMID:37267825
Homologous recombination repair gene-based risk model predicts prognosis and immune microenvironment for primary lung cancer after previous malignancies., PMID:37243581
SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption., PMID:37198221
PAI-1 mediates TGF-β1-induced myofibroblast activation in tenocytes via mTOR signaling., PMID:37143206
DNA Methylation of Window of Implantation Genes in Cervical Secretions Predicts Ongoing Pregnancy in Infertility Treatment., PMID:36982674
For research use only. Not for human or drug use.
