Catalog No.
YHC06401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val23-Cys185
Predicted molecular weight
20.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04090
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Prorelaxin H2, RLN2
The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists., PMID:40434342
Relaxin-2 Ameliorates Spinal Cord Injury by Inhibiting Microglia Activation., PMID:40392018
Relaxin 2 Suppresses Tumor Growth in Esophageal Squamous Cell Carcinoma EC9706 Cells Through Modulation of the STAT Signaling Pathway., PMID:40343386
Relaxin-2 mitigates the interaction between monocytes and endothelial cells by suppressing Egr-1., PMID:40192193
A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction., PMID:40037346
Relationship between relaxin-2 levels in serum and mode of conception in twin gestations: A prospective cohort study., PMID:39716018
Role of Relaxin Signaling in Cancer: A Review., PMID:39547477
C1QTNF Related protein 8 (CTRP8) is a marker of myeloid derived innate immune cell populations in the human breast cancer microenvironment., PMID:39542181
Engineering and Characterization of a Long-Half-Life Relaxin Receptor RXFP1 Agonist., PMID:39134056
Prognostic association of circulating relaxin-2 in acute heart failure., PMID:39002802
Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach., PMID:38841623
Relaxin-2 is a novel biomarker for differentiated thyroid carcinoma in humans., PMID:38815632
Identification and Quantification of Human Relaxin Proteins by Immunoaffinity-Mass Spectrometry., PMID:38739617
Significance of plasma relaxin-2 levels in patients with primary hypertension and type 2 diabetes mellitus., PMID:38451351
Programmed Death-Ligand (PD-L1), Epidermal Growth Factor (EGF), Relaxin, and Matrix Metalloproteinase-3 (MMP3): Potential Biomarkers of Malignancy in Canine Mammary Neoplasia., PMID:38256245
Specific expression and blood kinetics for relaxin 2, lipocalin 2, and tissue factor pathway inhibitor 2 at the canine placenta and pregnant bloods., PMID:38057091
Expression and Prognostic Value of m6A RNA Methylation-Related Genes in Thyroid Cancer., PMID:38033847
Identification and validation of molecular subtypes and a 9-gene risk model for breast cancer., PMID:37747033
Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives., PMID:37721595
The role of breast milk beta-endorphin and relaxin-2 on infant colic., PMID:37142649
The dual and multifaceted role of relaxin-2 in cancer., PMID:36947362
Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment., PMID:36921737
Tumor-activated neutrophils promote metastasis in breast cancer via the G-CSF-RLN2-MMP-9 axis., PMID:36801950
Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers., PMID:36566255
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function., PMID:35657397
A bibliometric review of peripartum cardiomyopathy compared to other cardiomyopathies using artificial intelligence and machine learning., PMID:35340600
Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2., PMID:34454945
An organ-on-a-chip model for pre-clinical drug evaluation in progressive non-genetic cardiomyopathy., PMID:34216608
Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases., PMID:33555858
Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat model., PMID:32859236
Recombinant human H2 relaxin (serelaxin) as a cardiovascular drug: aiming at the right target., PMID:32360533
Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans., PMID:32024951
Administration study of recombinant human relaxin-2 in horse for doping control purpose., PMID:31726484
Intraarticular injection of relaxin-2 alleviates shoulder arthrofibrosis., PMID:31160441
Human recombinant relaxin-2 does not attenuate hypertension or renal injury but exacerbates vascular dysfunction in a female mouse model of SLE., PMID:31125285
Healthy Donors Exhibit a CD4 T Cell Repertoire Specific to the Immunogenic Human Hormone H2-Relaxin before Injection., PMID:31101669
The Role of Relaxin-2 in Tissue Remodeling of Chronic Rhinosinusitis With Nasal Polyps., PMID:31007042
Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease., PMID:30918325
Emerging roles for the relaxin/RXFP1 system in cancer therapy., PMID:30763603
Commercial immunoassays for human relaxin-2., PMID:30633956
Relaxin in liver transplantation: A personal perspective., PMID:30550815
Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo., PMID:30287265
Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer., PMID:30126180
Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice., PMID:29806709
The subset of patients with acute heart failure able to secrete relaxin-2 at pregnancy concentrations could have a longer survival: a pilot study., PMID:29716428
Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma., PMID:29695398
Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis., PMID:29565035
Serum relaxin-2 as a novel biomarker for prostate cancer., PMID:29513121
Optimizing Hypertensive Acute Heart Failure Management with Afterload Reduction., PMID:29478124
Decreased Serum Relaxin-2 Is Correlated with Impaired Islet β-Cell Function in Patients with Unstable Angina and Abnormal Glucose Metabolism., PMID:29445056
For research use only. Not for human or drug use.
