Catalog No.
AHB98601
Biological activity
Immobilized human APOE (Cat #: AHB98601) at 5μg/mL (100 μL/well) can bind human TREM2 with a linear range of 0.6-65 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Lys19-His317
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P02649
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apo-E, Apolipoprotein E, APOE
Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy., PMID:40510419
Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways., PMID:40502621
Robust Serum Proteomic Signatures of APOE2., PMID:40501769
Impact of APOE4-related dementia risk in underrepresented groups from the All of Us research program., PMID:40501118
GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia., PMID:40495575
Pre-treatment serum apolipoprotein E: a promising prognostic indicator for nasopharyngeal carcinoma., PMID:40495209
Salivary levels of amyloid beta reflect brain amyloid beta burden in cognitively-normal older adults., PMID:40494737
Perceptual discrimination of complex objects: Apolipoprotein E e4 gene-dose effects in mid-life., PMID:40492513
Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia., PMID:40492085
Cell-type-specific Transcriptomic-wide Association Studies Detected 91 Independent Risk Genes for Alzheimer's Disease Dementia., PMID:40492066
Unraveling novel mechanisms of ATP-Binding cassette (ABC) transporter in insulin Resistance-induced amyloidogenesis., PMID:40482009
PCSK9 inhibition mitigates vulnerable plaque formation induced by hyperhomocysteinemia through regulating lipid metabolism and inflammation., PMID:40480522
Clinically relevant dosing of miR-145 micelles curbs atherosclerosis in vivo., PMID:40480516
Association of Alzheimer's disease concerns with amyloid burden and lifestyle behaviors in cognitively unimpaired older adults., PMID:40476544
Single-nucleus multiomics in brains from Hispanic individuals reveal APOE-ε4 -driven disruption of focal adhesion signaling in the presence of cerebrovascular pathology., PMID:40475150
Lipid metabolism disorder promoting retinal structural and functional damage in ApoE-/- mice with age superposition., PMID:40468378
High-phytosterol rapeseed oil prevents atherosclerosis by reducing intestinal barrier dysfunction and cholesterol uptake in ApoE-/- mice., PMID:40467190
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis., PMID:40466954
Unveiling XinJia-LuHuang Granules' protective mechanism against atherosclerosis: Integrating network pharmacology, metabolomics, and experimental validation., PMID:40466509
Alzheimer's disease plasma biomarkers in the Midwestern Amish., PMID:40465679
The lipidome and proteome of high-density lipoprotein are altered in menopause., PMID:40465474
Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles., PMID:40463820
Heritability of Alzheimer-related plasma biomarkers in the Amish population., PMID:40463532
Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE-/- mice., PMID:40462197
A rare gain of function variant of hepatic lipase attenuates hypercholesterolemia and atherosclerosis in mice via an LDL receptor-independent mechanism., PMID:40460236
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype., PMID:40457456
Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype., PMID:40456910
Causal association of cholesterol metabolism-related proteins with hepatocellular carcinoma and dysfunction-associated steatotic liver disease: a mendelian randomization study., PMID:40455174
APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses., PMID:40451545
Associations between platelet indices and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study., PMID:40450373
Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer's disease., PMID:40450296
Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula., PMID:40449878
Apolipoprotein E as a potential regulator of osteoclast-osteoblast coupling in material-induced bone formation., PMID:40449705
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition., PMID:40449269
From genetic roots to recent advancements in gene therapy targeting amyloid beta in Alzheimer's disease., PMID:40448320
Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer's disease pathology., PMID:40448221
Genetics and Epigenetics of Alzheimer's Disease: Understanding Pathogenesis and Exploring Therapeutic Potential., PMID:40447964
Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E-/-/LDLR-/- Double-Knockout Mice., PMID:40445431
Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE-Tau Axis via Human Cerebral Organoids with Immuno-SERS., PMID:40444455
Emerging blood biomarkers in Alzheimer's disease: a proteomic perspective., PMID:40441344
Predicting and preventing Alzheimer's disease., PMID:40440380
Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages., PMID:40439406
OVOL1 Promotes Proliferation and Metastasis of Non-Small Cell Lung Cancer by Regulating APOE-Mediated Cholesterol Metabolism., PMID:40437660
Cholesteryl Ester Transfer Protein Deficiency and Hyperalphalipoproteinemia., PMID:40436797
Depressive symptoms interact with CSF levels of p-tau in predicting cognitive performance in the early stages of Parkinson's disease., PMID:40435794
Semiparametric joint modeling for biomarker trajectory before disease onset., PMID:40433774
Prognostic Value of Apolipoprotein E in Predicting One-year Mortality in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease., PMID:40433394
Shorter Telomere Length in Individuals with Neurocognitive Disorder and APOE ε4 Genotype., PMID:40429722
[Dynamics of eosinophil infiltration and microglia activation in brain tissues of mice infected with Angiostrongylus cantonensis]., PMID:40425499
Acrolein-Triggered Ferroptosis and Protection by Intermittent Fasting via the AMPK/NRF2-CLOCK/BMAL1 Pathway., PMID:40423448
For research use only. Not for human or drug use.
