Catalog No.
AHB96101
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human PIGR (CAT #: AHB96101) is immobilized at 2 μg/mL (100 μL/well), the concentration of human IgM that produces 50% of the optimal binding response is found to be approximately 20-100 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Lys19-Arg638
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P01833
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Poly-Ig receptor, Polymeric immunoglobulin receptor, PIgR, PIGR, Hepatocellular carcinoma-associated protein TB6
The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs., PMID:40410595
pIgR-like4.2 enhances the antiviral immune response of zebrafish against spring viremia of carp virus., PMID:40250506
Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers., PMID:40242314
Understanding IgM Structure and Biology to Engineer New Antibody Therapeutics., PMID:40237925
Impact of afatinib on intestinal and salivary IgA: Immune response alterations linked to gastrointestinal side effects., PMID:40228698
Kinetics of pIgR and IgM immune responses in snakehead (Channa argus) to inactivated Aeromonas hydrophila via immersion and intraperitoneal injection., PMID:40169670
Helicobacter pylori CagA and Cag type IV secretion system activity have key roles in triggering gastric transcriptional and proteomic alterations., PMID:40047510
Design, Production, and Optimization of Antigen-Specific Recombinant Antitumor Dimeric IgA Antibody., PMID:40029519
The Na+-K+-ATPase alpha subunit is an entry receptor for white spot syndrome virus., PMID:39964166
Enhancing liver fibrosis detection: a novel PIGR-utilizing approach in chronic hepatitis B injury assessment., PMID:39955486
Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome., PMID:39858399
The protein ingredient quality of infant formula influences colonic physiology and microbiota and the serum metabolomic profile in neonatal mini-piglets., PMID:39779144
Ganoderma lucidum (Curtis) P. Karst. Immunomodulatory Protein Has the Potential to Improve the Prognosis of Breast Cancer Through the Regulation of Key Prognosis-Related Genes., PMID:39770537
Proteomic Insights into the Molecular Correlations Between Coronary Artery Disease and Peripheral Artery Disease in the Project Baseline Health Study., PMID:39763547
Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development., PMID:39747972
PIgR Autoantibody-abundant Circulating Vesicles Contributes to Biliary Injury in Biliary Atresia., PMID:39733605
Supplementation of Parachlorella sp. in feed promote the gut microbiome colonization and fecal IgA response of broiler in both early and late period., PMID:39631282
Unraveling the uterine fluid proteome of mares diagnosed with post-breeding and infectious endometritis., PMID:39616824
Proteomic and N-glycosylation analysis of fertile egg white during storage and incubation in chickens., PMID:39608286
IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori., PMID:39581230
Benzoic Acid potentiates intestinal IgA response in broiler chickens against Salmonella enterica Serovar Typhimurium infection., PMID:39531802
Airway epithelium damage in acute respiratory distress syndrome., PMID:39478566
Immunoglobulin M-based local production in skin-associated lymphoid tissue of flounder (Paralichthys olivaceus) initiated by immersion with inactivated Edwardsiella tarda., PMID:39461396
Macleaya cordata extract improves egg quality by altering gut health and microbiota in laying hens., PMID:39442200
Comparison of Whey N-Glycoproteins in Yak Colostrum and Mature Milk Based on 4D Label-Free Technology., PMID:39392371
DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway., PMID:39388305
Supplementation with Akkermansia muciniphila improved intestinal barrier and immunity in zebrafish (Danio rerio)., PMID:39357628
CD5L associates with IgM via the J chain., PMID:39333069
Proteome of plasma extracellular vesicles as a source of colorectal cancer biomarkers., PMID:39324200
The improvement of immunity and activation of TLR2/NF-κB signaling pathway by Romboutsia ilealis in broilers., PMID:39305205
Polymeric immunoglobulin receptor promotes Th2 immune response in the liver by increasing cholangiocytes derived IL-33: a diagnostic and therapeutic biomarker of biliary atresia., PMID:39288533
Molecular biomarkers involved in the progression of gallbladder inflammatory lesions to invasive cancer: A proteomic approach., PMID:39284282
Antibodies and complement are key drivers of thrombosis., PMID:39226900
Integrative Analysis of Multi-Omics Data to Identify Deregulated Molecular Pathways and Druggable Targets in Chronic Lymphocytic Leukemia., PMID:39202022
The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAM+/- mice to colitis and gut microbiota dysbiosis., PMID:39188786
IgT-mediated mucosal immunity and microbiota dynamics in snakehead (Channa argus) post Aeromonas veronii TH0426 and Aeromonas hydrophila TPS infection: implications for aquaculture disease management., PMID:39172273
Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases., PMID:39147169
Moderate Aerobic Exercise Induces Homeostatic IgA Generation in Senile Mice., PMID:39125769
Immune response to Aeromonas hydrophila and molecular characterization of polymeric immunoglobulin receptor in juvenile Megalobrama amblycephala., PMID:39117129
SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR., PMID:39066171
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer's disease., PMID:38987357
BTB and CNC homology 1 deficiency disrupts intestinal IgA secretion through regulation of polymeric immunoglobulin receptor expression., PMID:38981617
The IgA-pIgR System Is Dysregulated in Idiopathic Pulmonary Fibrosis., PMID:38976848
Molecular Mechanisms of Intestinal Protection by Levilactobacillus brevis 23017 against Salmonella typhimurium C7731-Induced Damage: Role of Nrf2., PMID:38930517
Expression of L1 Cell Adhesion Molecule, a Nephronal Principal Cell Marker, in Nephrogenic Adenoma., PMID:38901674
Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant., PMID:38886748
Structural and Biochemical Requirements for Secretory Component Interactions with Dimeric IgA., PMID:38809110
Exploring the evolutionary and pathogenic role of Acinetobacter baumannii biofilm-associated protein (Bap) through in silico structural modeling., PMID:38762620
Expression of genes related to ileal barrier function in heritage and modern broiler chickens., PMID:38717281
Possible transport routes of IgM to the gut of teleost fish., PMID:38657879
For research use only. Not for human or drug use.
