Catalog No.
AHB90401
Biological activity
Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenic peptide substrate Z-LR-AMC. The IC50 value is <11.0 nM.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Trp21-Ser141
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P01037
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cystain-SA-I, CST1, Cystatin-1, Cystatin-SN, Salivary cystatin-SA-1
Transforming Properties of E6/E7 Oncogenes from Beta-2 HPV80 in Primary Human Fibroblasts., PMID:40508156
Platelet-rich plasma inhibits ferroptosis and inflammation to alleviate frozen shoulder via activating the CST1/GPX4 signaling pathway., PMID:40274175
Induction of SOX17 with stimulation of WNT, TGF-beta, and FGF signaling drives embryonal carcinomas into the yolk-sac tumor lineage resulting in increased cisplatin resistance., PMID:40025812
CST1 promoted gastric cancer development by activating the AKT pathway., PMID:39721372
Protective humoral immunity induced by virus-like particles expressing Toxoplasma gondii CST1 or MIC8., PMID:39694399
TFAP2A Promotes Cell Progression and Suppresses Ferroptosis in Lung Adenocarcinoma via Activating Transcription of CST1., PMID:39692484
Analysis of the Correlation Between Toxoplasma gondii Seropositivity and Alzheimer's Disease., PMID:39599575
Knockdown of ENO1 promotes autophagy dependent-ferroptosis and suppresses glycolysis in breast cancer cells via the regulation of CST1., PMID:39503165
Heterologous immunization targeting the CST1 antigen confers better protection than ROP18 in mice., PMID:39320318
BRD9 promotes the progression of gallbladder cancer via CST1 upregulation and interaction with FOXP1 through the PI3K/AKT pathway and represents a therapeutic target., PMID:39306629
Enzymatically enhanced ultrastructure expansion microscopy unlocks expansion of in vitro Toxoplasma gondii cysts., PMID:39189782
Cystatin SN (CST1) Is a Poor Independent Prognostic Biomarker for Gastrointestinal Diffuse Large B-Cell Lymphoma., PMID:38959178
Clinical implications and mechanism of CST1 in gastric carcinoma based on database screening., PMID:38814219
A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is distinct from host homologues., PMID:38710711
Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer., PMID:38424293
Integrated Bioinformatics Analysis to Identify a Novel Four-Gene Prognostic Model of Breast Cancer and Reveal Its Association with Immune Infiltration., PMID:38305332
The functional role of CST1 and CCL26 in asthma development., PMID:38270326
Decoding the genetic landscape of allergic rhinitis: a comprehensive network analysis revealing key genes and potential therapeutic targets., PMID:38266128
TFAP2C Activates CST1 Transcription to Facilitate Breast Cancer Progression and Suppress Ferroptosis., PMID:38243003
Combination of serum CST1 and HE4 for early diagnosis of endometrial cancer., PMID:38077439
Comprehensive Multiomics Analyses Establish the Optimal Prognostic Model for Resectable Gastric Cancer : Prognosis Prediction for Resectable GC., PMID:37996637
Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps., PMID:37990964
Meibomian Gland Dysfunction Is Associated with Low Levels of Immunoglobulin Chains and Cystatin-SN., PMID:37894795
SPI1-Mediated Upregulation of the CST1 Gene as an Independent Poor Prognostic Factor Accelerates Metastasis in Esophageal Squamous Cell Carcinoma (ESCC) by Interacting with MMP2., PMID:37796690
Cystatin SN (CST1) as a Novel Salivary Biomarker of Periodontitis., PMID:37762137
Nasal epithelial gene expression and total IgE in children and adolescents with asthma., PMID:37742934
Cis- and trans-eQTM analysis reveals novel epigenetic and transcriptomic immune markers of atopic asthma in airway epithelium., PMID:37271320
Bioinformatic Analysis of Key Regulatory Genes in Adult Asthma and Prediction of Potential Drug Candidates., PMID:37241840
Protective mucosal and systemic immunity induced by virus-like particles expressing Toxoplasma gondii cyst wall protein., PMID:37104285
Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway., PMID:37075800
Transcriptome analysis of human peri-implant soft tissue and periodontal gingiva: a paired design study., PMID:37060358
Epithelium-derived cystatin SN inhibits house dust mite protease activity in allergic asthma., PMID:37026502
Cystatin SN in type 2 inflammatory airway diseases., PMID:36958985
MiR-942-5p inhibits tumor migration and invasion through targeting CST1 in esophageal squamous cell carcinoma., PMID:36848349
Human endoderm stem cells reverse inflammation-related acute liver failure through cystatin SN-mediated inhibition of interferon signaling., PMID:36670290
Transcriptional landscape of oncogene-induced senescence: a machine learning-based meta-analytic approach., PMID:36621646
Bronchial epithelial cell transcriptome shows endotype heterogeneity of asthma in patients with NSAID-exacerbated respiratory disease., PMID:36395984
Identifying Diagnostic and Prognostic Differentially Expressed Genes of Gastric Cancer Based on Bioinformatics Analyses of RNA-seq Data., PMID:36383109
CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1., PMID:36369321
CST1 promotes the proliferation and migration of PDGF-BB-treated airway smooth muscle cells via the PI3K/AKT signaling pathway., PMID:36354198
Identification of key genes and pathways in chronic rhinosinusitis with nasal polyps and asthma comorbidity using bioinformatics approaches., PMID:36059464
Weighted Correlation Network Analysis of Cancer Stem Cell-Related Prognostic Biomarkers in Esophageal Squamous Cell Carcinoma., PMID:35899307
Cystatin SN is a potent upstream initiator of epithelial-derived type 2 inflammation in chronic rhinosinusitis., PMID:35660375
Identification and Validation of Serum CST1 as a Diagnostic Marker for Differentiating Early-Stage Non-Small Cell Lung Cancer from Pulmonary Benign Nodules., PMID:35653624
Cystatin SN promotes epithelial-mesenchymal transition and serves as a prognostic biomarker in lung adenocarcinoma., PMID:35637432
Identifying key genes and functionally enriched pathways in Th2-high asthma by weighted gene co-expression network analysis., PMID:35550122
Feno differentiates epithelial gene expression clusters: Exploratory analysis from the MESOS randomized controlled trial., PMID:35537502
Role of the Long Intergenic Non-Protein-Coding RNA 1278/miR-185-5p/Cystatin SN Axis in Laryngeal Cancer Cells., PMID:35498540
Transcriptional profiling and network pharmacology analysis identify the potential biomarkers from Chinese herbal formula Huosu Yangwei Formula treated gastric cancer in vivo., PMID:34961592
Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma., PMID:34957724
For research use only. Not for human or drug use.
