Catalog No.
AHB88301
Biological activity
Measured by its ability to cleave a peptide substrate, NcarbobenzyloxyGly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is >2,000 pmol/min/µg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Leu431
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P00749
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PLAU, uPA, U-plasminogen activator, Urokinase-type plasminogen activator
Functional Characterization of Plasminogen Activator Urokinase as a Key Gene in Papillary Thyroid Carcinoma Lymph Node Metastasis., PMID:40454923
Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients., PMID:40375481
[Efficient capture and proteomics analysis of urinary extracellular vesicles by affinity purification]., PMID:40331614
Integrative bioinformatics and machine learning identify key crosstalk genes and immune interactions in head and neck cancer and Hodgkin lymphoma., PMID:40328901
PLAU serves as a prognostic biomarker correlated with perineural invasion in HNSCC., PMID:40319793
Identifying and validating PLAU as a potential prognostic biomarker for PDAC., PMID:40216916
Exploring the Effectiveness and Potential Pharmacological Mechanism of Minocycline for Spinal Cord Injury through Meta-Analysis and Network Pharmacology., PMID:40108485
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
mRNA expression profile from whole blood revealed a cluster of 25 shared differentially expressed genes inversely related in multiple sclerosis and inflammatory bowel disease., PMID:39893753
Cerebrospinal Fluid (CSF) Proteomic Signature in Preclinical and Clinical Alzheimer's disease (AD): Role of Adhesion Molecules., PMID:39877089
Using the AP1 Transcription Factor FOSL1 to Assess the Exacerbation of Psoriasis., PMID:39835554
Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation., PMID:39812944
Identification of hub programmed cell death-related genes and immune infiltration in Crohn's disease using bioinformatics., PMID:39744064
CLEC7A Knockdown Alleviates Ischemic Stroke by Inhibiting Pyroptosis and Microglia Activation., PMID:39735961
Screening and identification of potential target of 1'-acetoxychavicol acetate (ACA) in acquired lapatinib-resistant breast cancer., PMID:39698092
Deciphering the toxicity of polyhexamethylene guanidine phosphate in lung carcinogenesis: Mutational profiles and molecular mechanisms., PMID:39577803
Clinical Significance of Complement and Coagulation Cascades Genes for Patients With Acute Lymphoblastic Leukemia., PMID:39523585
Progress in Precision Medicine for Head and Neck Cancer., PMID:39518152
Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis., PMID:39511134
Identifying HIF1A and HGF as two hub genes in aortic dissection and function analysis by integrating RNA sequencing and single-cell RNA sequencing data., PMID:39479394
Development of biomarker signatures associated with anoikis to predict prognosis in patients with esophageal cancer: An observational study., PMID:39465737
Establishment of a Prognostic Model for Pancreatic Cancer Based on Hypoxia-Related Genes., PMID:39431298
Comprehensive analysis of the m6A demethylase FTO in endothelial dysfunction by MeRIP sequencing., PMID:39343042
Bioinformatics Analysis of the Expression and Prognostic Value of PLAU Gene in Wilms' Tumor., PMID:39197889
Bioinformatic analysis of the molecular targets of curcumin in colorectal cancer., PMID:39173464
A Bioinformatic Strategy for Investigating the Mechanism of Hispolon in the Treatment of Triple-Negative Breast Cancer Combined with In vitro Experiments., PMID:39108110
Manipulating host secreted protein gene expression: an indirect approach by HPV11/16 E6/E7 to suppress PBMC cytokine secretion., PMID:39095779
Transcriptional Induction of SERPINE1 and Fibrinolysis Inhibition as Predominant Effects of Glucocorticoids on the Cancer Coagulome., PMID:39060075
Comprehending the pharmacological mechanism of marine phenolic acids in bladder cancer therapy against matrix metalloproteinase 9 protein by integrated network pharmacology and in-silico approaches., PMID:39053173
Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder., PMID:38993198
Application of Proteomics and Machine Learning Methods to Study the Pathogenesis of Diabetic Nephropathy and Screen Urinary Biomarkers., PMID:38949094
Dissecting Crucial Gene Markers Involved in HPV-Associated Oropharyngeal Squamous Cell Carcinoma from RNA-Sequencing Data through Explainable Artificial Intelligence., PMID:38940026
Identification of drug targets for Sjögren's syndrome: multi-omics Mendelian randomization and colocalization analyses., PMID:38933282
Exploration of the shared pathways and common biomarker in adamantinomatous craniopharyngioma and type 2 diabetes using integrated bioinformatics analysis., PMID:38848397
Identification of vilazodone as a novel plasminogen activator inhibitor to overcome Alzheimer's disease through virtual screening, molecular dynamics simulation, and biological evaluation., PMID:38816779
Combining experiments and bioinformatics to identify transforming growth factor-β1 as a key regulator in angiotensin II-induced trophoblast senescence., PMID:38781757
Molecular characterization of positively selected genes contributing aquatic adaptation in marine mammals., PMID:38733518
PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration., PMID:38702016
Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease., PMID:38669542
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway., PMID:38663475
Surface protein profiling and subtyping of extracellular vesicles in body fluids reveals non-CSF biomarkers of Alzheimer's disease., PMID:38602321
Integrated transcriptome sequencing and weighted gene co-expression network analysis reveals key genes of papillary thyroid carcinomas., PMID:38560266
Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1., PMID:38487008
Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements., PMID:38469181
Up-regulation of extracellular-matrix and inflammation related genes in oral squamous cell carcinoma., PMID:38442470
Plasminogen activator urokinase interacts with the fusion protein and antagonizes the growth of Peste des petits ruminants virus., PMID:38440983
Inflammatory cytokines and oral lichen planus: a Mendelian randomization study., PMID:38390325
Transcriptomic analysis of Porphyromonas gingivalis-infected head and neck cancer cells: Identification of PLAU as a candidate prognostic biomarker., PMID:38363001
PLAU and GREM1 are prognostic biomarkers for predicting immune response in lung adenocarcinoma., PMID:38306567
The breast cancer coagulome in the tumor microenvironment and its role in prognosis and treatment response to chemotherapy., PMID:38237862
For research use only. Not for human or drug use.
