Catalog No.
AHB46201
Biological activity
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant human NFASC/Neurofascin (Cat #: AHB46201), immobilized at 6 μg/mL on a 96-well plate, is able to significantly enhance neurite outgrowth.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ile25-Leu1039
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O94856
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neurofascin, NFASC, KIAA0756
Note
For research use only.
Accumulation of Neurofascin at Nodes of Ranvier Is Regulated by a Paranodal Switch., PMID:32554548
Efficacy of low dose rituximab in treatment-resistant CIDP with antibodies against NF-155., PMID:32563125
Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2., PMID:32601750
Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database., PMID:32631246
[A case of neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy successfully treated with Cyclosporine A]., PMID:32641627
Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment., PMID:32903174
Optic, trigeminal, and facial neuropathy related to anti-neurofascin 155 antibody., PMID:33080117
Anti-pan-neurofascin IgM in COVID-19-related Guillain-Barré syndrome: Evidence for a nodo-paranodopathy., PMID:33190687
Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo., PMID:33228720
Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice., PMID:33410216
Endogenously expressed Ranbp2 is not at the axon initial segment., PMID:33536249
Neurofascin Is a Novel Component of Rod Photoreceptor Synapses in the Outer Retina., PMID:33643000
Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers., PMID:33643817
Neurofascin antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: from intrinsic genetic background to clinical manifestations., PMID:33782779
Bone Marrow-Derived SH-SY5Y Neuroblastoma Cells Infected with Kaposi's Sarcoma-Associated Herpesvirus Display Unique Infection Phenotypes and Growth Properties., PMID:33853962
The prevalence of anti-neurofascin-155 antibodies in patients with neuromyelitis optica spectrum disorders., PMID:33998675
The role of circTmeff-1 in incubation of context-induced morphine craving., PMID:34116208
Proteomics Study on the Cerebrospinal Fluid of Patients with Encephalitis., PMID:34235299
Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons., PMID:34240706
Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients., PMID:34262555
[Network pharmacology study of Tibetan medicine Corydalis Herba against acute myocardial ischemia]., PMID:34467696
A case with Neurofascin-155 IgG antibody-associated combined central and peripheral demyelination: Successfully treated with anti-CD20 monoclonal antibody., PMID:34624826
Clinical and Laboratory Features in Anti-NF155 Autoimmune Nodopathy., PMID:34728497
Loggerhead sea turtle Caretta caretta plasma biochemistry and proteome profile modulation during recovery., PMID:34839037
Diffuse Traumatic Injury in the Mouse Disrupts Axon-Myelin Integrity in the Cerebellum., PMID:35018831
Neuropathologic damage induced by radiofrequency ablation at different temperatures., PMID:35436702
Identification of NFASC and CHL1 as Two Novel Hub Genes in Endometriosis Using Integrated Bioinformatic Analysis and Experimental Verification., PMID:35496348
Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors., PMID:35685361
Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment., PMID:35850303
PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells., PMID:36109561
Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage., PMID:36346134
Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination., PMID:36996106
Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry., PMID:37288813
Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer's disease., PMID:37988184
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease., PMID:38589621
Clinical characteristics of patients with autoimmune nodopathy with anti-neurofascin155 antibodies., PMID:38726012
Anti-neurofascin-155 antibody mediated a distinct phenotype of chronic inflammatory demyelinating polyradiculoneuropathy., PMID:38771386
[Clinical features of anti-neurofascin-155 antibody positive autoimmune nodopathy in 6 children]., PMID:39039882
Different Patterns of Autoantibody Secretion by Peripheral Blood Mononuclear Cells in Autoimmune Nodopathies., PMID:39173087
Aquilaria crassna Extract Exerts Neuroprotective Effect against Benzo[a]pyrene-Induced Toxicity in Human SH-SY5Y Cells: An RNA-Seq-Based Transcriptome Analysis., PMID:39203863
Evaluation of circulating plasma proteins in prostate cancer using mendelian randomization., PMID:39287922
Clinical Manifestations and Treatment Responses in Pediatric Neurofascin 155-IgG4 Autoimmune Nodopathy., PMID:39823553
Pan-neurofascin autoimmune nodoparanodopathy: A case report and literature review., PMID:39854764
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis., PMID:40028697
Super-resolution of nodal and paranodal disruption in anti-pan-neurofascin-associated autoimmune nodopathy., PMID:40051618
Mendelian Randomization Analysis of the Possible Causal Relationships Between Neurodevelopment-Related Proteins and Bipolar Disorder., PMID:40123161
Epitope Mapping of Anti-Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients., PMID:40129269
[Pan-neurofascin autoimmune nodopathy - an emerging and treatable differential diagnosis to Guillain-Barré syndrome]., PMID:40135266
Anti-neurofascin-186 associated combined central and peripheral demyelination (CCPD): A novel entity., PMID:40157142
A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC., PMID:40379966
For research use only. Not for human or drug use.
