Catalog No.
AMN56601
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of human squamous cell carcinoma cells (FaDu). When 5 x 10^4 cells/well are added to recombinant Mouse Chil3/Ym1 (Cat #: AMN56601) coated plates, cell adhesion is enhanced in a dose dependent manner after 1 hour incubation at 37 ℃. The ED50 for this effect is 0.3-1.2 μg/mL.
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Met1-Tyr398
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O35744
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Chitinase-like protein 3, Beta-N-acetylhexosaminidase Ym1, Chitinase-3-like protein 3, ECF-L, Eosinophil chemotactic cytokine, Secreted protein Ym1, Chil3, Chi3l3, Ym1
A secreted fatty acid- and retinol- binding protein from Heligmosomoides polygyrus suppresses host macrophage polarization., PMID:40501701
Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft-versus-host disease with MSCs treatment., PMID:40443676
Macrophage activation determines muscle wasting in pancreatic cancer., PMID:40442475
[Dynamics of eosinophil infiltration and microglia activation in brain tissues of mice infected with Angiostrongylus cantonensis]., PMID:40425499
Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ regulatory T cells., PMID:39667222
Co-expression gene module analysis in response to attenuated cercaria vaccine reveals a critical role for NK cells in protection against Schistosoma mansoni., PMID:39563428
CLCA1 and BPIFB1 are potential novel biomarkers for asthma: an iTRAQ analysis., PMID:39552876
Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages., PMID:39405117
Airspaces-derived exosomes contain disease-relevant protein signatures in a mouse model of cystic fibrosis (CF)-like mucoinflammatory lung disease., PMID:39386033
Immunometabolic Approaches Mitigating Foreign Body Response and Transcriptome Characterization of the Foreign Body Capsule., PMID:39148172
Nobiletin Regulates Polyinosinic-polycytidylic Acid-induced Inflammation in Macrophages Partially via the PPAR-γ Signaling Pathway., PMID:39129280
Low to moderate dose 137Cs (γ) radiation promotes M2 type macrophage skewing and reduces atherosclerotic plaque CD68+ cell content in ApoE(-/-) mice., PMID:38816571
Inflammatory and immunopathological differences in brains of permissive and non-permissive hosts with Angiostrongylus cantonensis infection can be identified using 18F/FDG/PET-imaging., PMID:38805557
LncRNA TUG1 mediates microglial inflammatory activation by regulating glucose metabolic reprogramming., PMID:38802677
Zhilong Huoxue Tongyu Capsule regulates the macrophage polarization and inflammatory response via the let-7i/TLR9/MyD88 signaling pathway., PMID:38636581
Chensinin-1b Alleviates DSS-Induced Inflammatory Bowel Disease by Inducing Macrophage Switching from the M1 to the M2 Phenotype., PMID:38397947
Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages., PMID:38331933
Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury., PMID:38310257
Ym1 protein crystals promote type 2 immunity., PMID:38194250
Molecular analysis of XPO1 inhibitor and gemcitabine-nab-paclitaxel combination in KPC pancreatic cancer mouse model., PMID:38131168
HSP90, a Common Therapeutic Target for Suppressing Skin Injury Caused by Exposure to Chemically Diverse Classes of Blistering Agents., PMID:37914412
5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury., PMID:37771779
Puerarin alleviates sleep disorders in aged mice related to repairing intestinal mucosal barrier., PMID:37698689
Arteriosclerosis Derived from Cutaneous Inflammation Is Ameliorated by the Deletion of IL-17A and IL-17F., PMID:36982506
Irreversible evolutionary loss of chitin-degrading ability in the chitinase-like protein Ym1 under positive selection in rodents., PMID:36883357
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells., PMID:36368330
Unbalanced Arginine pathway and altered maturation of pleural macrophages in Th2-deficient mice during Litomosoides sigmodontis filarial infection., PMID:36353644
Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH., PMID:36334837
Pathological examination of Ym1, a chitinase family protein, in Mesocestoides corti-infected mice., PMID:36244794
Monocytes maintain central nervous system homeostasis following helminth-induced inflammation., PMID:36070344
Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation., PMID:36052067
An update on Ym1 and its immunoregulatory role in diseases., PMID:35967383
M1 and M2 macrophages phenotypes modulation after stimuli with materials used in endodontic treatment., PMID:34755788
Decoding the Transcriptional Response to Ischemic Stroke in Obese and Non-obese Mice Brain., PMID:34702150
HSPB1 inhibitor J2 attenuates lung inflammation through direct modulation of Ym1 production and paracrine signaling., PMID:34649353
Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure., PMID:34544431
Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts., PMID:34415189
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages., PMID:33782087
Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency., PMID:33662226
Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells., PMID:33436596
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis., PMID:33340526
Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression., PMID:32575718
RELMα is Induced in Airway Epithelial Cells by Oncostatin M Without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo., PMID:32471168
Galectins, Eosinophiles, and Macrophages May Contribute to Schistosoma japonicum Egg-Induced Immunopathology in a Mouse Model., PMID:32231658
The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury., PMID:32155215
Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice., PMID:32072024
TSPO Modulates IL-4-Induced Microglia/Macrophage M2 Polarization via PPAR-γ Pathway., PMID:31879837
Targeted delivery of Chil3/Chil4 siRNA to alveolar macrophages using ternary complexes composed of HMG and oligoarginine micelles., PMID:31840707
Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite., PMID:31708913
dPGS Regulates the Phenotype of Macrophages via Metabolic Switching., PMID:31631571
For research use only. Not for human or drug use.
