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Recombinant Human NCAM2 Protein, C-His (Active)

Catalog #:   AHA51601 Specific References (50) DATASHEET
Applications: Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Expression system: Mammalian Cells
Accession: O15394
Protein length: Leu20-Asn697 (Arg49Glu, Gly72Glu, Leu163Phe, Gly374Asp)
Overview

Catalog No.

AHA51601

Biological activity

Measured by the ability of the immobilized protein to support the adhesion of human breast cancer cells (T47D). The ED50 for this effect is typically 0.3-1.5 μg/mL.

Expression system

Mammalian Cells

Species

Homo sapiens (Human)

Protein length

Leu20-Asn697 (Arg49Glu, Gly72Glu, Leu163Phe, Gly374Asp)

Nature

Recombinant

Endotoxin level

<0.1 EU/μg of the protein by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Accession

O15394

Applications

Bioactivity, ELISA, Immunogen, SDS-PAGE, WB

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

NCAM-2, N-CAM-2, NCAM21, NCAM2, Neural cell adhesion molecule 2

Data Image
References

Changes in the Immune Profile and Chromatin Accessibility of Peripheral Regulatory T Cells in Psoriasis Patients Before and After Treatment With Biologics., PMID:40269508

Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 Neurons., PMID:39574639

Machine learning model base on metabolomics and proteomics to predict cognitive impairment in Parkinson's disease., PMID:39394257

TAZ downregulated ANXA1 expression to modulate myeloma cell interactions with bone marrow mesenchymal stromal cells., PMID:39032857

Investigation of genetic determinants of cognitive change in later life., PMID:38238328

Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)., PMID:37724425

Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits., PMID:37522285

Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons., PMID:37083330

Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression., PMID:37031335

Repeated administration of acrylamide for 28 days suppresses adult neurogenesis of the olfactory bulb in young-adult rats., PMID:36801352

Repeated administration of acrylamide for 28 days reduces late-stage progenitor cells and immature granule cells accompanying impaired neurite outgrowth in the adult hippocampal neurogenesis in young-adult rats., PMID:36328537

Cell adhesion proteins in the cerebrospinal fluid of neonates prenatally exposed to Zika virus: A case-control study., PMID:36300719

The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes., PMID:36251052

ARID2 suppression promotes tumor progression and upregulates cytokeratin 8, 18 and β-4 integrin expression in TP53-mutated tobacco-related oral cancer and has prognostic implications., PMID:35869277

circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-κB Pathway., PMID:35687299

Identification of Novel Cerebrospinal Fluid Biomarkers for Cognitive Decline in Aneurysmal Subarachnoid Hemorrhage: A Proteomic Approach., PMID:35602555

Population Genomic Sequencing Delineates Global Landscape of Copy Number Variations that Drive Domestication and Breed Formation of in Chicken., PMID:35391799

The Hidden Side of NCAM Family: NCAM2, a Key Cytoskeleton Organization Molecule Regulating Multiple Neural Functions., PMID:34576185

New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization., PMID:34299022

The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs., PMID:33723406

Guide Cells Support Muscle Regeneration and Affect Neuro-Muscular Junction Organization., PMID:33669272

A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell., PMID:33608310

Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo., PMID:33548223

A molecular marker of milk composition traits in NCAM2 gene of Chinese Holstein., PMID:33314987

Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2., PMID:32601750

NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3., PMID:32043120

Spatial Determination of Neuronal Diversification in the Olfactory Epithelium., PMID:30530861

NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor., PMID:29895898

Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation., PMID:29522129

Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans., PMID:29367452

Gene CG15630 (fipi) is involved in regulation of the interpulse interval in Drosophila courtship song., PMID:29191114

Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons., PMID:28266018

Alterations of androgen receptor-regulated enhancer RNAs (eRNAs) contribute to enzalutamide resistance in castration-resistant prostate cancer., PMID:27221037

NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?, PMID:27596683

Diagnosis of Van den Ende-Gupta syndrome: Approach to the Marden-Walker-like spectrum of disorders., PMID:27375131

Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease., PMID:26611261

The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map., PMID:26446231

OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor., PMID:25875008

mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer., PMID:25710561

Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels., PMID:25632147

21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders., PMID:25464110

Identifying rare variants for genetic risk through a combined pedigree and phenotype approach: application to suicide and asthma., PMID:25335167

5' isomiR variation is of functional and evolutionary importance., PMID:25056318

Comparison of gene and protein expressions in rats residing in standard cages with those having access to an exercise wheel., PMID:24719897

Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors., PMID:24361078

Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals., PMID:23952781

The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation., PMID:23341449

A novel method for the simultaneous enrichment, identification, and quantification of phosphopeptides and sialylated glycopeptides applied to a temporal profile of mouse brain development., PMID:22843994

Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem., PMID:22837392

Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome., PMID:22694054

Datasheet
$ 360
Product specifications
50 μg 360 100 μg 580

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For research use only. Not for human or drug use.

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Recombinant Human NCAM2 Protein, C-His (Active) [AHA51601]
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