Catalog No.
AHA51601
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of human breast cancer cells (T47D). The ED50 for this effect is typically 0.3-1.5 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu20-Asn697 (Arg49Glu, Gly72Glu, Leu163Phe, Gly374Asp)
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O15394
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NCAM-2, N-CAM-2, NCAM21, NCAM2, Neural cell adhesion molecule 2
Changes in the Immune Profile and Chromatin Accessibility of Peripheral Regulatory T Cells in Psoriasis Patients Before and After Treatment With Biologics., PMID:40269508
Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 Neurons., PMID:39574639
Machine learning model base on metabolomics and proteomics to predict cognitive impairment in Parkinson's disease., PMID:39394257
TAZ downregulated ANXA1 expression to modulate myeloma cell interactions with bone marrow mesenchymal stromal cells., PMID:39032857
Investigation of genetic determinants of cognitive change in later life., PMID:38238328
Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)., PMID:37724425
Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits., PMID:37522285
Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons., PMID:37083330
Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression., PMID:37031335
Repeated administration of acrylamide for 28 days suppresses adult neurogenesis of the olfactory bulb in young-adult rats., PMID:36801352
Repeated administration of acrylamide for 28 days reduces late-stage progenitor cells and immature granule cells accompanying impaired neurite outgrowth in the adult hippocampal neurogenesis in young-adult rats., PMID:36328537
Cell adhesion proteins in the cerebrospinal fluid of neonates prenatally exposed to Zika virus: A case-control study., PMID:36300719
The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes., PMID:36251052
ARID2 suppression promotes tumor progression and upregulates cytokeratin 8, 18 and β-4 integrin expression in TP53-mutated tobacco-related oral cancer and has prognostic implications., PMID:35869277
circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-κB Pathway., PMID:35687299
Identification of Novel Cerebrospinal Fluid Biomarkers for Cognitive Decline in Aneurysmal Subarachnoid Hemorrhage: A Proteomic Approach., PMID:35602555
Population Genomic Sequencing Delineates Global Landscape of Copy Number Variations that Drive Domestication and Breed Formation of in Chicken., PMID:35391799
The Hidden Side of NCAM Family: NCAM2, a Key Cytoskeleton Organization Molecule Regulating Multiple Neural Functions., PMID:34576185
New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization., PMID:34299022
The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs., PMID:33723406
Guide Cells Support Muscle Regeneration and Affect Neuro-Muscular Junction Organization., PMID:33669272
A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell., PMID:33608310
Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo., PMID:33548223
A molecular marker of milk composition traits in NCAM2 gene of Chinese Holstein., PMID:33314987
Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2., PMID:32601750
NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3., PMID:32043120
Spatial Determination of Neuronal Diversification in the Olfactory Epithelium., PMID:30530861
NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor., PMID:29895898
Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation., PMID:29522129
Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans., PMID:29367452
Gene CG15630 (fipi) is involved in regulation of the interpulse interval in Drosophila courtship song., PMID:29191114
Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons., PMID:28266018
Alterations of androgen receptor-regulated enhancer RNAs (eRNAs) contribute to enzalutamide resistance in castration-resistant prostate cancer., PMID:27221037
NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?, PMID:27596683
Diagnosis of Van den Ende-Gupta syndrome: Approach to the Marden-Walker-like spectrum of disorders., PMID:27375131
Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease., PMID:26611261
The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map., PMID:26446231
OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor., PMID:25875008
mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer., PMID:25710561
Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels., PMID:25632147
21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders., PMID:25464110
Identifying rare variants for genetic risk through a combined pedigree and phenotype approach: application to suicide and asthma., PMID:25335167
5' isomiR variation is of functional and evolutionary importance., PMID:25056318
Comparison of gene and protein expressions in rats residing in standard cages with those having access to an exercise wheel., PMID:24719897
Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors., PMID:24361078
Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals., PMID:23952781
The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation., PMID:23341449
A novel method for the simultaneous enrichment, identification, and quantification of phosphopeptides and sialylated glycopeptides applied to a temporal profile of mouse brain development., PMID:22843994
Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem., PMID:22837392
Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome., PMID:22694054