Catalog No.
AHA13301
Biological activity
Measured by its ability to inhibit anti-CD3 antibody induced IL-2 or IFNgamma secretion by human T cells. The ED50 for this effect is 1-6 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln30-Trp248
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O00478
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BTN3A3, Butyrophilin subfamily 3 member A3, BTF3
PSMB4: a potential biomarker and therapeutic target for depression, perspective from integration analysis of depression GWAS data and human plasma proteome., PMID:39979251
Updated genetic background of generalized pustular psoriasis as an autoinflammatory keratinization disease., PMID:39698752
A Ménage à trois: NLRC5, immunity, and metabolism., PMID:39035010
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome., PMID:38898508
Genetic analysis of different subtypes of aseptic pustulosis in the Chinese population., PMID:38651209
Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing., PMID:38374404
A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing., PMID:37993425
Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes., PMID:37903831
Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders., PMID:37418754
BTN3A3 evasion promotes the zoonotic potential of influenza A viruses., PMID:37380775
Integrating GWAS and proteome data to identify novel drug targets for MU., PMID:37369724
Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders., PMID:37085628
Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells., PMID:36824912
Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population., PMID:36804966
BTN3A3 inhibits the proliferation, migration and invasion of ovarian cancer cells by regulating ERK1/2 phosphorylation., PMID:36059652
Multi-omics analysis of the expression and prognostic value of the butyrophilins in breast cancer., PMID:34411352
BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells., PMID:34260935
Prognostic and Therapeutic Significance of BTN3A Proteins in Tumors., PMID:34149914
Low expression of BTN3A3 indicates poor prognosis and promotes cell proliferation, migration and invasion in non-small cell lung cancer., PMID:33850875
High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis., PMID:33101298
Analysis of macaque BTN3A genes and transcripts in the extended MHC: conserved orthologs of human γδ T cell modulators., PMID:31384962
Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells., PMID:31227581
LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3., PMID:30858559
The Armadillo (Dasypus novemcinctus): A Witness but Not a Functional Example for the Emergence of the Butyrophilin 3/Vγ9Vδ2 System in Placental Mammals., PMID:29527206
Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family., PMID:28382515
Altered expression of Butyrophilin (BTN) and BTN-like (BTNL) genes in intestinal inflammation and colon cancer., PMID:27957327
Gene-Based Genome-Wide Association Analysis in European and Asian Populations Identified Novel Genes for Rheumatoid Arthritis., PMID:27898717
Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children., PMID:26329766
Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection., PMID:25928882
Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin., PMID:25637025
Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia., PMID:25243493
Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination., PMID:25098560
The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells., PMID:24703779
Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells., PMID:23833237
Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells., PMID:22970192
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies., PMID:22846996
Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers., PMID:22612312
Incidence of apoptosis and transcript abundance in bovine follicular cells is associated with the quality of the enclosed oocyte., PMID:22578626
Differential role for CD277 as a co-regulator of the immune signal in T and NK cells., PMID:21918970
Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity., PMID:20610803
An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression., PMID:20421211
A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane., PMID:12124930
For research use only. Not for human or drug use.
