Catalog No.
YHC05201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu441-Asn875
Predicted molecular weight
48.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04035
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMGCR, HMG-CoA reductase
Tumorous cholesterol biosynthesis curtails anti-tumor immunity by preventing MTOR-TFEB-mediated lysosomal degradation of CD274/PD-L1., PMID:40509568
PBX3-HMGCR Axis Promotes Hepatocellular Carcinoma Progression Through Enhancing De Novo Cholesterol Biosynthesis., PMID:40508020
Metabolomics combined with network pharmacology reveals the anti-hepatoma effects of terpenoids from Polygonatum kingianum var. grandifolium and Polygonatum sibiricum Redouté as well as differences in their terpenoid metabolites., PMID:40474061
Srebf and Runx3 regulate hepatic HMG-CoA reductase and intracellular cholesterol under hypoxia., PMID:40464811
Kidney Transcriptomic and Proteomic Analyses Provide New Insight into the Pathogenesis of IgA Nephropathy in Mice., PMID:40461644
Optimization of main components of artificial compound feed (ACF) for Hippocampus kuda based on the synergistic expression of biological clock genes., PMID:40448724
From cranes to crutches: the disabling potential of necrotising myopathy., PMID:40441745
Assessing the impact of PCSK9 and HMGCR inhibitor on reproductive endocrine diseases: A drug-target Mendelian randomization analysis., PMID:40441203
Marein from Coreopsis tinctoria Nutt. alleviates oxidative stress and lipid accumulation via SIRT1/Nrf2 signaling., PMID:40437103
Anti-HMGCR myopathy: a first case report from North Africa and literature insights., PMID:40421031
The P53N236S Mutation Plays a Regulatory Role in Osteosarcoma Metastasis Via the Cholesterol-Hedgehog Pathway., PMID:40420741
Trichoderma sp. strain AM6 whole-genome guided untargeted metabolomics: Terpenoid backbone synthesis and modulation of VOCs in tea (Camellia sinensis L.)., PMID:40412041
Strontium regulating lipid metabolism of bovine hepatocytes via SIRT1/SREBPs pathway., PMID:40403884
Loperamide-induced constipation is associated with excessive accumulation of bile acids and cholesterol in the liver of mice; attenuation by hesperidin., PMID:40389132
Integrated transcriptomics and metabolomics unravel the key metabolic pathways involved in the therapeutic mechanism of Salvianic acid A against hepatic fibrosis., PMID:40389097
Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening., PMID:40372435
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance., PMID:40355720
Astrocyte lactoferrin deficiency affects the construction and function of spinal neurons by regulating cholesterol metabolism., PMID:40334811
Emerging atypical clinicopathological manifestations of immune-mediated necrotizing myopathy (IMNM)., PMID:40315785
Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis., PMID:40289090
Hemp seed protein exerts its hypoglycemic and hypolipidemic effects through degradation into short peptides., PMID:40279904
Effectiveness of proprotein convertase subtilisin/kexin type 9 inhibitors in managing hypercholesterolemia post-statin-associated immune-mediated necrotizing myopathy: report of five cases and literature review., PMID:40249406
Mammalian Ste20-like kinase 1 regulates AMPK to mitigate the progression of non-alcoholic fatty liver disease., PMID:40247356
CRISPR/Cas9-mediated SHP-1-knockout T cells combined with simvastatin enhances anti-tumor activity in humanized-PDX HCC model., PMID:40241752
IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming., PMID:40240362
HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2., PMID:40234623
Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis., PMID:40233623
Sesamin regulates breast cancer through reprogramming of lipid metabolism., PMID:40233124
Causal Association Between Cholesterol-Lowering Drugs and Diabetic Microvascular Complications: A Drug-Target Mendelian Randomization Study., PMID:40225015
Glyphosate exposure impairs glucose and lipid metabolism by disturbing the circadian clock system in mice liver., PMID:40204262
Pediatric Immune-Mediated Necrotizing Myopathy: A Single-Center Retrospective Cohort Study., PMID:40203548
Yeast hydrolysate and exercise ameliorate high-fat diet-induced obesity in C57BL/6 mice., PMID:40181294
Persistent exanthema mainly on the trunk with pathologically dermal interstitial mucin as anti-HMGCR myopathy-associated skin rash: Case series., PMID:40152349
Hypolipidemic effect and mechanism of Hedan tablet based on network pharmacology., PMID:40151127
Regulation of CNS Lipids by Protease Activated Receptor 1., PMID:40123504
Expression of the cholesterol transporter SR-B1 in melanoma cells facilitates inflammatory signaling leading to reduced cholesterol synthesis., PMID:40120430
Joint Associations of APOC3 and LDL-C-Lowering Variants With the Risk of Coronary Heart Disease., PMID:40105833
Genetic association of lipids and lipid-lowering drug target genes with breast cancer., PMID:40095250
Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: drug target Mendelian randomization study., PMID:40082904
Discovery of ASGR1 and HMGCR dual-target inhibitors based on supervised learning, molecular docking, molecular dynamics simulations, and biological evaluation., PMID:40080975
Animal Model Screening for Hyperlipidemic ICR Mice., PMID:40076768
Mendelian randomization-based observational cohort study on drug targets: Impact of antihypertensive and lipid-lowering therapies on inflammatory cytokines., PMID:40068040
Matairesinol discovered as a key active ingredient in Chinese dark tea protects against high-fat induced endothelial injury via activating AMPK phosphorylation., PMID:40057143
Statins' protective effects on focal epilepsy are independent of LDL-C., PMID:40053059
Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study., PMID:40052268
Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes., PMID:40046180
Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia., PMID:40025348
Sodium alginate improves lipid disruption and alters the composition of the gut microbiota in farnesoid X receptor-null mice., PMID:40024913
Low density lipoprotein cholesterol but not statins is the direct cause of intracerebral hemorrhage., PMID:40023359
[Inhibitory Effect of Simvastatin Combined with Doxorubicin on Biological Functions of Diffuse Large B-Cell Lymphoma Cells and Its Mechanism]., PMID:40017190
For research use only. Not for human or drug use.
