Catalog No.
YMK01801
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Phe117-Pro297
Predicted molecular weight
22.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q80UW2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
F-box only protein 2, FBX2, FBXO2
Alisol B 23-Acetate Down-Regulated GRP94 to Restore Endoplasmic Reticulum Homeostasis on Non-Alcoholic Steatohepatitis., PMID:40051602
Identification of Putative Serum Autoantibodies Associated with Post-Acute Sequelae of COVID-19 via Comprehensive Protein Array Analysis., PMID:40004214
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining., PMID:39879982
FBXO2 as a switch guides a special fate of tumor clones evolving into a highly malignant transcriptional subtype in oral squamous cell carcinoma., PMID:39487312
FBXO2 promotes the progression of papillary thyroid carcinoma through the p53 pathway., PMID:39343799
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm., PMID:38887896
Integrated analysis of scRNA-seq and bulk RNA-seq identifies FBXO2 as a candidate biomarker associated with chemoresistance in HGSOC., PMID:38590858
Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes., PMID:38460933
Post-Transcriptional Regulator RBM47 Stabilizes FBXO2 mRNA to Advance Osteoarthritis Development: WGCNA Analysis and Experimental Validation., PMID:38070024
F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit., PMID:37576703
Identification of key modules and driving genes in nonalcoholic fatty liver disease by weighted gene co-expression network analysis., PMID:37488473
Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway., PMID:36982617
A Preliminary Study in Immune Response of BALB/c and C57BL/6 Mice with a Locally Allergic Rhinitis Model., PMID:36797980
Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model., PMID:36609445
Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions., PMID:35802605
Focal facial dermal dysplasias type III: Two families with Setleis syndrome in China., PMID:35713327
FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development., PMID:35525855
Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration., PMID:35409356
FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan., PMID:34515398
Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer., PMID:33622332
Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D., PMID:33549845
FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway., PMID:32984335
Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain., PMID:32931479
FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells., PMID:32549792
Identification of potential crucial genes in monocytes for atherosclerosis using bioinformatics analysis., PMID:32314637
Lectin-Type Ubiquitin Ligase Subunits: Fbs Proteins and Their Applications for Use., PMID:32306330
Response to Comment on Liu et al. Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 2017;66:689-698., PMID:31959695
Comment on Liu et al. Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 2017;66:689-698., PMID:31959694
The prognostic significance of FBXO2 expression in colorectal cancer., PMID:31949582
Fbxo2VHC mouse and embryonic stem cell reporter lines delineate in vitro-generated inner ear sensory epithelia cells and enable otic lineage selection and Cre-recombination., PMID:30179592
Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation., PMID:30052682
Support vector machine classifier for prediction of the metastasis of colorectal cancer., PMID:29328363
FBXO2, a novel marker for metastasis in human gastric cancer., PMID:29269301
Potential sperm contributions to the murine zygote predicted by in silico analysis., PMID:28916718
An engineered high affinity Fbs1 carbohydrate binding protein for selective capture of N-glycans and N-glycopeptides., PMID:28534482
Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease., PMID:28341977
Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice., PMID:27932386
SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation., PMID:27756846
Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase., PMID:27487926
Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq., PMID:27461947
A DsbA-Deficient Periplasm Enables Functional Display of a Protein with Redox-Sensitive Folding on M13 Phage., PMID:27210801
The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3., PMID:26460611
Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity., PMID:25878288
F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing., PMID:24469452
Differential proteomic profiling in human spermatozoa that did or did not result in pregnancy via IVF and AID., PMID:24115602
Novel approach to identifying autoantibodies in rheumatoid synovitis with a biotinylated human autoantigen library and the enzyme-labeled antigen method., PMID:23044167
Using a ubiquitin ligase as an unfolded protein sensor., PMID:22227190
Lectin-like ERAD players in ER and cytosol., PMID:19665047
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance., PMID:19285438
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases., PMID:18203720
For research use only. Not for human or drug use.
