Catalog No.
YHN56301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly486-Ser755
Predicted molecular weight
30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BRZ2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RING-type E3 ubiquitin transferase TRIM56, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 56, RING finger protein 109, TRIM56, RNF109
TRIM56 enhances adenoviral E1A steady state to improve oncolytic adenovirus therapy efficacy., PMID:40459263
Comprehensive analysis of TRIM56's prognostic value and immune infiltration in Pan-Cancer., PMID:40258986
TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3., PMID:39928840
PRDX6 Prevents NNMT Ubiquitination and Degradation as a Nonenzymatic Mechanism to Promote Ovarian Cancer Progression., PMID:39887931
Emerging Roles of TRIM56 in Antiviral Innate Immunity., PMID:39861861
HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responses., PMID:39747662
LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease., PMID:39349450
TRIM56 restricts Coxsackievirus B infection by mediating the ubiquitination of viral RNA-dependent RNA polymerase 3D., PMID:39348396
TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1-Mediated Neuronal PANoptosis in Spinal Cord Injury., PMID:39291396
PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR., PMID:39059592
Key roles for phosphorylation and the Coiled-coil domain in TRIM56-mediated positive regulation of TLR3-TRIF-dependent innate immunity., PMID:38556084
Disassembly of the TRIM56-ATR complex promotes cytoDNA/cGAS/STING axis-dependent intervertebral disc inflammatory degeneration., PMID:38488012
Accumulation of TOX high mobility group box family member 3 promotes the oncogenesis and development of hepatocellular carcinoma through the MAPK signaling pathway., PMID:38463397
TRIM56-mediated production of type I interferon inhibits intracellular replication of Rickettsia rickettsii., PMID:38358243
TRIM56: a promising prognostic immune biomarker for glioma revealed by pan-cancer and single-cell analysis., PMID:38348047
TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase., PMID:38206764
[The I226R protein of African swine fever virus inhibits the cGAS-STING-mediated innate immune response]., PMID:38147982
Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19., PMID:38051999
Circulating CD8 lymphocytes predict response to atezolizumab-bevacizumab in hepatocellular carcinoma., PMID:37990855
TRIMming down Mycobacterium tuberculosis replication: TRIM32 is required for bacterial ubiquitination and autophagy induction in macrophages., PMID:40395310
Golgi-protein 73 facilitates vimentin polymerization in hepatocellular carcinoma., PMID:37564210
TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions., PMID:37168870
The Functions of TRIM56 in Antiviral Innate Immunity and Tumorigenesis., PMID:36902478
TRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion., PMID:36870986
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules., PMID:36692217
TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein., PMID:36471347
New Avenues to Explore in SARS-CoV-2 Infection: Both TRIM25 and TRIM56 Positively Correlate with VEGF, GAS6, and sAXL in COVID-19 Patients., PMID:36450108
TRIM56 impairs HBV infection and replication by inhibiting HBV core promoter activity., PMID:36084850
TRIM56 positively regulates TNFα-induced NF-κB signaling by enhancing the ubiquitination of TAK1., PMID:35952808
Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation., PMID:35830814
TRIM56 Reduces Radiosensitization of Human Glioblastoma by Regulating FOXM1-Mediated DNA Repair., PMID:35696011
TRIM56 overexpression restricts porcine epidemic diarrhoea virus replication in Marc-145 cells by enhancing TLR3-TRAF3-mediated IFN-β antiviral response., PMID:35503719
Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells., PMID:35062293
Hyperresponsive cytosolic DNA-sensing pathway in monocytes from primary Sjögren's syndrome., PMID:35022662
Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling., PMID:34609794
Comparison of the Ability of High and Low Virulence Strains of Non-cytopathic Bovine Viral Diarrhea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium., PMID:33898551
Identification of TRIM56 as a Potential Biomarker for Lung Adenocarcinoma., PMID:33707970
TRIM56 suppresses the malignant development of hepatocellular carcinoma via targeting RBM24 and inactivating the Wnt signaling., PMID:33577026
Systematic review of the antiviral properties of TRIM56: a potential therapeutic intervention for COVID-19., PMID:32903131
The Restrictome of Flaviviruses., PMID:32152893
The E3 ligase TRIM56 is a host restriction factor of Zika virus and depends on its RNA-binding activity but not miRNA regulation, for antiviral function., PMID:31251739
Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56., PMID:31000690
Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2)., PMID:30685767
Suppression of the SAP18/HDAC1 complex by targeting TRIM56 and Nanog is essential for oncogenic viral FLICE-inhibitory protein-induced acetylation of p65/RelA, NF-κB activation, and promotion of cell invasion and angiogenesis., PMID:30670829
MiR-9 promotes multiple myeloma progression by regulating TRIM56/NF-κB pathway., PMID:30637864
Poly r(C) Binding Protein 1 Regulates Posttranscriptional Expression of the Ubiquitin Ligase TRIM56 in Ovarian Cancer., PMID:30281912
UBXN3B positively regulates STING-mediated antiviral immune responses., PMID:29899553
TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing., PMID:29426904
TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling., PMID:29214775
NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway., PMID:28939760
For research use only. Not for human or drug use.
