Catalog No.
YHF89201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala22-Val340
Predicted molecular weight
38.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q01804
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OTU domain-containing protein 4, HIN-1, HIV-1-induced protein HIN-1, OTUD4, KIAA1046
OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression., PMID:40338740
Ubiquitin-dependent proteasomal degradation of small hepatitis B virus surface antigen mediated by TRIM21 and antagonized by OTUD4., PMID:40277358
Bourbon and Mycbp function with Otu to promote Sxl protein expression in the Drosophila female germline., PMID:40215271
Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy., PMID:40208866
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death., PMID:40086433
PPDPF-mediated regulation of BCAA metabolism enhances mTORC1 activity and drives cholangiocarcinoma progression., PMID:40025229
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway., PMID:39888301
OTUD4-mediated inhibition of YAP1 signaling pathway in ovarian cancer: Implications for macrophage polarization and recruitment., PMID:39778277
Decoding polyubiquitin regulation of KV7. 1 functional expression with engineered linkage-selective deubiquitinases., PMID:39345403
AP3B1 facilitates PDIA3/ERP57 function to regulate rabies virus glycoprotein selective degradation and viral entry., PMID:39128851
A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma., PMID:38945202
Posttranslational protein modifications as gatekeepers of cancer immunogenicity., PMID:38747288
E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS., PMID:38725852
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells., PMID:38553613
Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers., PMID:38530357
NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma., PMID:38518721
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway., PMID:38429268
Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases., PMID:38215174
Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins., PMID:38089580
Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1., PMID:38040050
A novel mutation in RNF216 gene in an Indian case with Gordon Holmes syndrome., PMID:37977846
CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation., PMID:37726265
OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1., PMID:37642406
Epigenetic Age Acceleration in Frontotemporal Lobar Degeneration: A Comprehensive Analysis in the Blood and Brain., PMID:37508584
Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction., PMID:37162556
Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes., PMID:37149835
OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis., PMID:36411454
Meta-Analysis of EGF-Stimulated Normal and Cancer Cell Lines to Discover EGF-Associated Oncogenic Signaling Pathways and Prognostic Biomarkers., PMID:36381277
Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation., PMID:35830814
Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0., PMID:35516420
MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway., PMID:35317262
DNMT1 facilitates growth of breast cancer by inducing MEG3 hyper-methylation., PMID:35109842
Integrative Analyses of Genes Associated with Hashimoto's Thyroiditis., PMID:34493981
OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex., PMID:32973272
The Integrated Analyses of Driver Genes Identify Key Biomarkers in Thyroid Cancer., PMID:32812852
OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6., PMID:31964525
Distinct expression and prognostic value of OTU domain-containing proteins in non-small-cell lung cancer., PMID:31612050
New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules., PMID:31138677
Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS., PMID:30410068
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling., PMID:29395066
Comparative proteome and peptidome analysis of the cephalic fluid secreted by Arapaima gigas (Teleostei: Osteoglossidae) during and outside parental care., PMID:29065179
Data integration in physiology using Bayes' rule and minimum Bayes' factors: deubiquitylating enzymes in the renal collecting duct., PMID:28039431
SKELETAL MUSCLE MITOCHONDRIAL ALTERATIONS IN CARBOXYL TERMINUS OF HSC70 INTERACTING PROTEIN (CHIP) -/- MICE., PMID:28593200
Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family., PMID:26588485
Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase., PMID:25944111
STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity., PMID:25258038
A human XPC protein interactome--a resource., PMID:24366067
Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP., PMID:24113144
Zebrafish transforming growth factor-β-stimulated clone 22 domain 3 (TSC22D3) plays critical roles in Bmp-dependent dorsoventral patterning via two deubiquitylating enzymes Usp15 and Otud4., PMID:23665588
Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination., PMID:23656588
For research use only. Not for human or drug use.
