Catalog No.
YHF42201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser111-Tyr254
Predicted molecular weight
19.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P61289
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activator of multicatalytic protease subunit 3, Proteasome activator complex subunit 3, PA28g, 11S regulator complex subunit gamma, PA28gamma, Ki nuclear autoantigen, REG-gamma, PSME3, Proteasome activator 28 subunit gamma
Cell-autonomous innate immunity by proteasome-derived defence peptides., PMID:40044870
Downregulated PSME3 Contributes to Severe Preeclampsia by Promoting Trophoblast Cell Apoptosis., PMID:39906994
PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation., PMID:39103492
Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans., PMID:39083540
Dynamic role of CUL4B in radiation-induced intestinal injury-regeneration., PMID:38689033
Comprehensive analysis of PSME3: from pan-cancer analysis to experimental validation., PMID:38312840
LncRNA PSMA3-AS1 activates the progression of triple-negative breast cancer cells by blocking miR-186-5p-mediated PSME3 inhibition., PMID:38279473
PSME3 induces radioresistance and enhances aerobic glycolysis in cervical cancer by regulating PARP1., PMID:37467687
MicroRNA-130a-3p impedes the progression of papillary thyroid carcinoma through downregulation of KPNB1 by targeting PSME3., PMID:37166548
Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes., PMID:37118550
SUMOylation-mediated PSME3-20S proteasomal degradation of transcription factor CP2c is crucial for cell cycle progression., PMID:36706181
The prognosis value of proteasome activator subunit 3 expression in gastric cancer., PMID:36515625
De novo mutations within metabolism networks of amino acid/protein/energy in Chinese autistic children with intellectual disability., PMID:36320054
Candidate genes for infertility: an in-silico study based on cytogenetic analysis., PMID:35918717
Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome., PMID:35743599
Indirubin-3'-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma., PMID:35344764
Identification of Candidate lncRNA and Pseudogene Biomarkers Associated with Carbon-Nanotube-Induced Malignant Transformation of Lung Cells and Prediction of Potential Preventive Drugs., PMID:35270630
Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study., PMID:35176998
Immunogenomic Landscape Analysis of Prognostic Immune-Related Genes in Hepatocellular Carcinoma., PMID:34745496
Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis., PMID:34260942
Immune evasion by cancer stem cells., PMID:33778133
The 20S proteasome activator PA28γ controls the compaction of chromatin., PMID:33526472
Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3., PMID:32923122
Silencing PSME3 induces colorectal cancer radiosensitivity by downregulating the expression of cyclin B1 and CKD1., PMID:31630568
The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma., PMID:31258724
PSME3 Promotes TGFB1 Secretion by Pancreatic Cancer Cells to Induce Pancreatic Stellate Cell Proliferation., PMID:31205573
MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ., PMID:30942447
Proteasome activator subunit 3 promotes pancreatic cancer growth via c-Myc-glycolysis signaling axis., PMID:27756569
Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility., PMID:27003159
The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens., PMID:26776519
Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells., PMID:26410814
Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity., PMID:26201457
Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis., PMID:24901344
The proteasome activator PA28γ, a negative regulator of p53, is transcriptionally up-regulated by p53., PMID:24531141
MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3., PMID:23762407
Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks., PMID:22134242
Proteasome activator PA28γ stimulates degradation of GSK3-phosphorylated insulin transcription activator MAFA., PMID:21830322
Butyrylcholinesterase in metabolic syndrome., PMID:20797821
REGgamma/PA28gamma proteasome activator interacts with PML and Chk2 and affects PML nuclear bodies number., PMID:19556897
Identification of PSME3 as a novel serum tumor marker for colorectal cancer by combining two-dimensional polyacrylamide gel electrophoresis with a strictly mass spectrometry-based approach for data analysis., PMID:16893879
Cloning and sequence analysis of cDNA for the proteasome activator PA28-beta subunit of flounder (Paralichthys olivaceus)., PMID:14597164
Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina., PMID:14585497
Identification and linkage of the proteasome activator complex PA28 subunit genes in zebrafish., PMID:10849367
Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes., PMID:9590240
Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit., PMID:9382924
PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes., PMID:9218537
For research use only. Not for human or drug use.
