Catalog No.
YHJ50601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala31-Gly475
Predicted molecular weight
51.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BXB1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GPR48, Leucine-rich repeat-containing G-protein coupled receptor 4, LGR4, G-protein coupled receptor 48
The role of LGR4 in bone metabolism and tumor bone metastasis., PMID:40469438
Therapeutic and Prognostic Potential of G Protein-Coupled Receptors in Lung Adenocarcinoma: Evidence From Transcriptome Data and In Vitro Experiments., PMID:40364562
The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma., PMID:40264052
Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren's Syndrome Related Dry Eye., PMID:40238113
Screening and functional studies of Norrin-related nanobodies., PMID:40216217
LGR signaling and metabolic regulation: A new frontier in addressing insulin resistance and diabetes treatment., PMID:40186561
Screening, expression, and functional validation of camelid-derived nanobodies targeting RSPO2., PMID:40179630
LGR4 (GPR48): The Emerging Inter-Bridge in Osteoimmunology., PMID:40149584
Generation and characterisation of seven induced pluripotent stem cell lines from two patients with Parkinson's disease carrying the pathological variant c.1087G>T of the LGR4 gene., PMID:40144372
Deficiency of neuronal LGR4 increases energy expenditure and inhibits food intake via hypothalamic leptin signaling., PMID:40069508
Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproduction., PMID:40001176
Role of endosomal RANKL-LGR4 signaling during osteoclast differentiation., PMID:39954074
Unraveling the gender-specific molecular landscape of lung squamous cell carcinoma progression., PMID:39895519
Role of Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors 4-6 (LGR4-6) in the Ovary and Other Female Reproductive Organs: A Literature Review., PMID:39874091
LGR4 is a key regulator of hepatic gluconeogenesis., PMID:39826817
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK., PMID:39788290
Functional and Biological Characterization of the LGR5Δ5 Splice Variant in HEK293T Cells., PMID:39769183
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling., PMID:39753551
LGR4 promotes proliferation and homing via activation of the NF‑κB signaling pathway in multiple myeloma., PMID:39749708
Stem Cell Markers LGR5, LGR4 and Their Immediate Signalling Partners are Dysregulated in Preeclampsia., PMID:39688759
Activation of STAT6 in Intestinal Epithelial Cells Predisposes to Gut Inflammation., PMID:39670708
RANKL regulates differentially breast cancer stem cell properties through its RANK and LGR4 receptors., PMID:39662745
The frequency of known germline LGR4 missense variant in the ethnic groups of West Siberia., PMID:39644398
LGR4 Deficiency Aggravates Skin Inflammation and Epidermal Hyperplasia in Imiquimod-Induced Psoriasis., PMID:39563507
Case report: exome sequencing identified mutations in the LRP5 and LGR4 genes in a case of osteoporosis with recurrent fractures and extraskeletal manifestations., PMID:39525853
The Genomic Landscape of Wilson Disease in a Pan India Disease Cohort and Population-Scale Data., PMID:39535360
Baicalein inhibits cell proliferation and induces apoptosis in brain glioma cells by downregulating the LGR4-EGFR pathway., PMID:39468312
RSPO/LGR signaling regulates proliferation of adult hippocampal neural stem cells., PMID:39432578
Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer., PMID:39415992
Anti-liver cancer therapeutic targets and safety of usenamine A in experimental liver cancer., PMID:39360781
LGR4 attenuates MGP expression and suppresses EGFR activation-induced triple-negative breast cancer metastasis., PMID:39113859
Signaling pathways associated with Lgr6 to regulate osteogenesis., PMID:39033993
LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance., PMID:39033139
FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation., PMID:38921956
A Systematic Review of the Prevalence of Germline BRCA mutations in North Asia Breast Cancer Patients., PMID:38918649
Exome Sequencing: the Search for Mutations Associated with Hereditary Breast and Ovarian Cancers in the Tuvan Ethnic Group (A Pilot Study)., PMID:38896321
RANKL, but Not R-Spondins, Is Involved in Vascular Smooth Muscle Cell Calcification through LGR4 Interaction., PMID:38891922
LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK., PMID:38798561
Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice., PMID:38782937
Cellular landscape of adrenocortical carcinoma at single-nuclei resolution., PMID:38759836
Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of β-catenin and ILK signaling pathways after inflammatory vascular injury., PMID:38677673
Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML., PMID:38579286
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice., PMID:38440827
Targeting LGR4-Wnt activates ferroptosis and reverses drug resistance in colorectal cancer., PMID:38355778
BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells., PMID:38292169
Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance., PMID:38291304
Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila., PMID:38284837
Circ-ZNF236 mediates stem cells from apical papilla differentiation by regulating LGR4-induced autophagy., PMID:38240345
Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells., PMID:38229108
Development of a TLR-Based Model That Can Predict Prognosis, Tumor Microenvironment, and Drug Response for Esophageal Squamous Cell Carcinoma., PMID:38206423
For research use only. Not for human or drug use.
