Catalog No.
RHC01801
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
C-X-C motif chemokine 4, PF-4, Oncostatin-A, Endothelial cell growth inhibitor, CXCL4, Iroplact, Platelet factor 4, PF4, SCYB4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P02776
Applications
ELISA, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
KKO
The Role of CXCL4 in Systemic Sclerosis: DAMP, Auto-Antigen and Biomarker., PMID:40141068
Pro-Fibrotic Macrophage Subtypes: SPP1+ Macrophages as a Key Player and Therapeutic Target in Cardiac Fibrosis?, PMID:40072075
The role and mechanism study of Cxcl14 in chronic critically ill cardiac dysfunction., PMID:40010139
Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo., PMID:39464886
Effect of tocilizumab on endothelial and platelet-derived CXC-chemokines and their association with inflammation and myocardial injury in STEMI patients undergoing primary PCI., PMID:39374793
Type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from head and neck cancer patients., PMID:39304856
7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively., PMID:39284947
Research progress of the chemokine/chemokine receptor axes in the oncobiology of multiple myeloma (MM)., PMID:38475811
High levels of PD-L1 on platelets of NSCLC patients contributes to the pharmacological activity of Atezolizumab., PMID:37857253
Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin Ligand., PMID:37759488
The immunology of PF4 polyanion interactions., PMID:37603711
Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow., PMID:37409530
Antibodies against platelet factor 4 and the risk of cerebral venous sinus thrombosis in patients with vaccine-induced immune thrombotic thrombocytopenia., PMID:37394121
Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity., PMID:37150909
New perspectives on the induction and acceleration of immune-associated thrombosis by PF4 and VWF., PMID:36926331
SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis., PMID:36864432
Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients., PMID:36761728
Heparin-Independent and Heparin-Dependent Anti-CXCL4 Antibodies Have a Reciprocal Expression in a Systemic Sclerosis Patients' Cohort., PMID:36546902
Chemokine PF4 Inhibits EV71 and CA16 Infections at the Entry Stage., PMID:35579435
Production of anti-PF4 antibodies in antiphospholipid antibody-positive patients is not affected by COVID-19 vaccination., PMID:35131751
Contribution to the peripheral vasculopathy and endothelial cell dysfunction by CXCL4 in Systemic Sclerosis., PMID:34556381
Insights into origins and specificities of autoantibodies in systemic sclerosis., PMID:34506340
Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma., PMID:34203660
New Autoantibody Specificities in Systemic Sclerosis and Very Early Systemic Sclerosis., PMID:33800661
Soluble Biomarkers for Prediction of Vascular and Gastrointestinal Disease Severity in Patients with Systemic Sclerosis., PMID:40270643
Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis., PMID:33420306
BIOMARKERS OF DISEASE ACTIVITY IN SYSTEMIC SCLEROSIS., PMID:33310967
Platelet activation contributes to hypoxia-induced inflammation., PMID:33264579
Cytokine Profiling in Chinese SLE Patients: Correlations with Renal Dysfunction., PMID:33134397
Structural Features and PF4 Functions that Occur in Heparin-Induced Thrombocytopenia (HIT) Complicated by COVID-19., PMID:33050376
The anti-CXCL4 antibody depletes CD4(+)CD25(+)FOXP3(+) regulatory T cells in CD4+ T cells from chronic osteomyelitis patients by the STAT5 pathway., PMID:32954739
The role of thrombospondin-1 in the pathogenesis of antiphospholipid syndrome., PMID:32709480
Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature., PMID:32707718
CXCL4 promoted the production of CD4+CD25+FOXP3+treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway., PMID:32538218
Atherosclerosis: orchestrating cells and biomolecules involved in its activation and inhibition., PMID:32085889
Interleukin-4 and interleukin-13 as possible therapeutic targets in systemic sclerosis., PMID:31400638
Differential CpG methylation of the promoter of interleukin 8 and the first intron of tissue factor in Antiphospholipid syndrome., PMID:31103268
Effects of CXCL4/CXCR3 on the lipopolysaccharide-induced injury in human umbilical vein endothelial cells., PMID:31073998
Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin-induced thrombocytopenia., PMID:30582672
Distinct Binding Characteristics of Pathogenic Anti-Platelet Factor-4/Polyanion Antibodies to Antigens Coated on Different Substrates: A Perspective on Clinical Application., PMID:30540167
Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses., PMID:30527622
Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain., PMID:30456228
Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality., PMID:30169632
Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies., PMID:30076959
Biomarkers for Pulmonary Vascular Remodeling in Systemic Sclerosis: A Pathophysiological Approach., PMID:29971007
Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin-induced thrombocytopenia., PMID:29723924
Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8., PMID:29321259
Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice., PMID:28810552
An update on biomarker discovery and use in systemic sclerosis., PMID:28730919
Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity., PMID:28530237
For research use only. Not for human or drug use.
