Catalog No.
YMC25301
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ile21-Leu410
Predicted molecular weight
45.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P18242
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CPSD, CTSD, Cathepsin D
A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk Individuals., PMID:40507347
Proteomics-Based Exploration of the Hepatoprotective Mechanism of α-Lipoic Acid in Rats with Iron Overload-Induced Liver Injury., PMID:40429916
Autophagy Process in Parkinson's Disease Depends on Mutations in the GBA1 and LRRK2 Genes., PMID:40388077
Inhibiting Immune Crosstalk by Modulation of the Intracellular Function and Extracellular Environment of Diseased Microglia to Boost Parkinson's Disease Therapy., PMID:40366277
[Rubioncolin C targets cathepsin D to induce autophagosome accumulation and suppress gastric cancer]., PMID:40350910
Characterization, expression profiling, and immunological role of Cathepsin D in Sebastes schlegelii during bacterial infection., PMID:40339947
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux., PMID:40280227
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells., PMID:40181129
Glycosylation Triggers Cathepsin D Maturation and Secretion to Promote Gastric Cancer Development., PMID:40122458
Integrated Proteomics and Lipidomics Analysis of Hippocampus to Reveal the Metabolic Landscape of Epilepsy., PMID:40092809
Function of lamp2 Gene Response to Vibrio vulnificus Infection and LPS Stimulation in the Half-Smooth Tongue Sole (Cynoglossus semilaevis)., PMID:40076623
Effects of Dietary Copper Sources and Levels on Liver Copper Metabolism and the Expression of Transporters in Growing Pigs., PMID:40003008
Genetic colocalization of cathepsins H, D, and L1 with Alzheimer's disease: Implications for biomarker and therapeutic target discovery., PMID:39982062
From protective enzyme to facilitator of amyloid propagation: Cathepsin D-mediated amyloid fibril fragmentation., PMID:39952498
Vasoinhibin is Generated by the Renin-angiotensin System., PMID:39903548
Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy., PMID:39800383
Low-density lipoprotein receptor-related protein 6 ameliorates cardiac hypertrophy by regulating CTSD/HSP90α signaling during pressure overload., PMID:39779966
The Expression of Proteases and the Oligopeptide Transporter PepT1 in the Yolk Sac Membrane, Proventriculus, and Small Intestine During the Development of Anas platyrhynchos domestica Embryo., PMID:39765655
Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H+-ATPase., PMID:39757940
Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model., PMID:39744681
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis., PMID:39726152
N-glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer., PMID:39716927
AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity., PMID:39675352
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration., PMID:39675125
A Novel Variant of the CTSD Gene Associated with Juvenile-onset Neuronal Ceroid Lipofuscinosis Type 10: A Case Report and Literature Review., PMID:39656415
Apoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure., PMID:39616671
Vitamin D promotes autophagy to inhibit LPS-induced lung injury via targeting cathepsin D., PMID:39570382
New preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry., PMID:39520708
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α., PMID:39477683
Transcriptome Analysis Reveals the Early Development in Subcutaneous Adipose Tissue of Laiwu Piglets., PMID:39457885
A combined analysis of bulk RNA-seq and scRNA-seq was performed to investigate the molecular mechanisms associated with the occurrence of myocardial infarction., PMID:39363266
Cleistanthin A derivative disrupts autophagy and suppresses head and neck squamous cell carcinoma progression via targeted vacuolar ATPase., PMID:39343784
Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis., PMID:39263947
AUF1-mediated inhibition of autophagic lysosomal degradation contributes to CagA stability and Helicobacter pylori-induced inflammation., PMID:39068523
Dietary fishmeal replacement by Clostridium autoethanogenum protein meal influences the nutritional and sensory quality of turbot (Scophthalmus maximus) via the TOR/AAR/AMPK pathways., PMID:39056058
Investigating and Annotating the Human Peptidome Profile from Urine under Normal Physiological Conditions., PMID:39051237
Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting., PMID:39032642
Pro-cathepsin D prevents aberrant protein aggregation dependent on endoplasmic reticulum protein CLN6., PMID:39032464
Lipopolysaccharide-Induced Lysosomal Cell Death Through Reactive Oxygen Species in Rat Liver Cell Clone 9., PMID:39031462
Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis., PMID:39019115
Lassa virus Z protein hijacks the autophagy machinery for efficient transportation by interrupting CCT2-mediated cytoskeleton network formation., PMID:39007910
Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons., PMID:38928416
Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis., PMID:38863498
Pathobiology of the autophagy-lysosomal pathway in the Huntington's disease brain., PMID:38854113
Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis., PMID:38837708
Late-onset Krabbe disease presenting as spastic paraplegia - implications of GCase and CTSB/D., PMID:38837642
Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit., PMID:38815149
[Associations of serum neuromarkers with clinical features of Parkinson's disease]., PMID:38676689
Enhancement of Acetate-Induced Apoptosis of Colorectal Cancer Cells by Cathepsin D Inhibition Depends on Oligomycin A-Sensitive Respiration., PMID:38672489
For research use only. Not for human or drug use.
