Catalog No.
YHB97901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys175
Predicted molecular weight
22.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P02511
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Rosenthal fiber component, CRYA2, HspB5, Alpha-crystallin B chain, HSPB5, Heat shock protein beta-5, Alpha(B)-crystallin, CRYAB, Renal carcinoma antigen NY-REN-27
TANGO2 binds crystallin alpha B and its loss causes desminopathy., PMID:40480980
Single-Cell RNA Sequencing of the Primary Visual Cortex in Mice With Optic Nerve Injury., PMID:40408096
Activation mechanism of small heat shock protein HSPB5 revealed by disease-associated mutants., PMID:40377988
Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta., PMID:40372913
Decreased Expression of Alzheimer's Disease-Related Genes in Cancer May Contribute to the Inverse-Relationship-a Computational Study., PMID:40352571
Molecular Signatures of Exercise Adaptation in Arabian Racing Horses: Transcriptomic Insights from Blood and Muscle., PMID:40282391
The p.K90N mutation in human HSPB5 highlights the critical role of lysine 90 in chaperone function and structural integrity., PMID:40250722
Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins., PMID:40241479
Zebrafish as a model for crystallin-associated congenital cataracts in humans., PMID:40206405
Whole-exome sequencing screening for candidate genes and potential pathogenic variants associated with early-onset high myopia in 47 Chinese families., PMID:40175531
Hypertrophic Cardiomyopathy-Associated CRYABR123W Activates Calcineurin, Reduces Calcium Sequestration, and Alters the CRYAB Interactome and the Proteomic Response to Pathological Hypertrophy., PMID:40141027
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease., PMID:40122840
Structural characterization and functional analysis of human αB-crystallin with the p.R11G mutation: Insights into cataractogenesis and cardiomyopathy., PMID:40086543
Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls., PMID:40063790
An antisense oligonucleotide targeting the heat-shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis., PMID:40033950
Comparative transcriptomic and co-expression network analysis identifies key gene modules involved in heat stress responses in goats., PMID:39956229
Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling., PMID:39932799
Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein., PMID:39883729
CRYAB is upregulated and predicts clinical prognosis in kidney renal clear cell carcinoma., PMID:39854102
Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta., PMID:39763959
In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis., PMID:39742283
Proteomic Profiling of Pre- and Post-Surgery Saliva of Glioblastoma Patients: A Pilot Investigation., PMID:39684695
Novel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation., PMID:39682748
Alleviation of lipopolysaccharide-induced heart inflammation in poultry treated with carnosic acid via the NF-κB and MAPK pathways., PMID:39657120
Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function., PMID:39651239
Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM., PMID:39609421
Effect of Short-Term Restraint Stress on the Expression of Genes Associated with the Response to Oxidative Stress in the Hypothalamus of Hypertensive ISIAH and Normotensive WAG Rats., PMID:39594444
Mutation of CRYAB encoding a conserved mitochondrial chaperone and antiapoptotic protein causes hereditary optic atrophy., PMID:39561005
WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis., PMID:39444000
Effects of treadmill exercise on endoplasmic reticulum protein folding and endoplasmic reticulum-associated protein degradation pathways in APP/PS1 mice., PMID:39397952
Bioinformatics analysis of effective biomarkers and immune infiltration in type 2 diabetes with cognitive impairment and aging., PMID:39375405
Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson's disease reveals unique and shared pathological features., PMID:39345456
Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular Remodeling., PMID:39282298
Enhanced and cross-reactive in vitro memory B cell response against Epstein-Barr virus nuclear antigen 1 in multiple sclerosis., PMID:39257578
Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes., PMID:39225101
ANXA5 predicts prognosis and immune response and mediates proliferation and migration in head and neck squamous cell carcinoma., PMID:39168258
CRYAB Promotes Colorectal Cancer Progression by Inhibiting Ferroptosis Through Blocking TRIM55-Mediated β-Catenin Ubiquitination and Degradation., PMID:39126452
Generation of human induced pluripotent stem cell (hiPSC) lines derived from three patients carrying the pathogenic CRYAB (A527G) mutation and one non-carrier family member., PMID:39053319
Plasma alpha B crystallin as potential biomarker for predicting pre-operative seizures in glioma., PMID:38971757
Deciphering the molecular landscape of ionising radiation-induced eye damage with the help of genomic data mining., PMID:38963141
TGFβ1-Induced Fibrotic Responses of Conjunctival Fibroblasts through the Wnt/β-Catenin/CRYAB Signaling Pathway., PMID:38879081
CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1., PMID:38787373
Neuroinflammation and neurodegeneration following traumatic brain injuries., PMID:38739360
Biological effects and mechanism of β-amyloid aggregation inhibition by penetrable recombinant human HspB5-ACD structural domain protein., PMID:38678965
Lens Cytoskeleton: An Update on the Etiopathogenesis of Human Cataracts., PMID:38650819
Dynamic transcriptome profiles of skeletal muscle growth and development in Shaziling and Yorkshire pigs using RNA-sequencing., PMID:38647104
[Research on the anti-tumor effects of CRYAB in prostate cancer]., PMID:38619403
Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM., PMID:38585788
Significant genomic introgression from grey junglefowl (Gallus sonneratii) to domestic chickens (Gallus gallus domesticus)., PMID:38556896
Insights into the dual nature of αB-crystallin chaperone activity from the p.P39L mutant at the N-terminal region., PMID:38548822
For research use only. Not for human or drug use.
