Immunochemical Characteristics and Functional Activity of Monoclonal Antibodies Obtained to the Recombinant Form of Pneumolysin., PMID:39945949
Preliminary Evaluation of the Safety and Immunogenicity of a Novel Protein-Based Pneumococcal Vaccine in Healthy Adults Aged 18-49: A Phase Ia Randomized, Double Blind, Placebo-Controlled Clinical Study., PMID:39203953
Analysis of Immunobiological Properties of Recombinant Streptococcus pneumoniae Pneumolysin., PMID:39090461
Fusion of PspA to detoxified pneumolysin enhances pneumococcal vaccine coverage., PMID:38096222
ΔA146Ply-HA stem protein immunization protects mice against influenza A virus infection and co-infection with Streptococcus pneumoniae., PMID:37531919
A novel immuno-molecular strategy for the detection of Streptococcus pneumoniae serotypes in human cerebrospinal and middle ear fluids., PMID:37348647
Preparation a Recombinant Form of Pneumolysin Protein from Streptococcus pneumoniae., PMID:37160796
Immunoinformatics-aided design of a new multi-epitope vaccine adjuvanted with domain 4 of pneumolysin against Streptococcus pneumoniae strains., PMID:36829109
Construction and protective efficacy of a novel Streptococcus pneumoniae fusion protein vaccine NanAT1-TufT1-PlyD4., PMID:36389808
Immune response induced in mice by a hybrid rPotD-PdT pneumococcal protein., PMID:35994444
Streptococcus pneumoniae interactions with the complement system., PMID:35967850
Magnetic Nanoclusters Increase the Sensitivity of Lateral Flow Immunoassays for Protein Detection: Application to Pneumolysin as a Biomarker for Streptococcus pneumoniae., PMID:35745381
Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA., PMID:35648835
Corrected and Republished from: "A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge"., PMID:35076289
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae., PMID:35033388
Polyvalent Immunoglobulin Preparations Inhibit Pneumolysin-Induced Platelet Destruction., PMID:34918314
Subcutaneous immunization with the fusion protein ΔA146Ply-SP0148 confers protection against Streptococcus pneumoniae infection., PMID:34848296
A Comparison Between Recombinant Listeria GAPDH Proteins and GAPDH Encoding mRNA Conjugated to Lipids as Cross-Reactive Vaccines for Listeria, Mycobacterium, and Streptococcus., PMID:33953709
Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin., PMID:33760879
Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease., PMID:33671422
Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro., PMID:33351126
Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity., PMID:32650398
Preclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid., PMID:32532546
Immunization with Recombinant Pneumolysin Induces the Production of Antibodies and Protects Mice in a Model of Systemic Infection Caused by Streptococcus pneumoniae., PMID:32146631
A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults., PMID:31895881
Early pneumococcal clearance in mice induced by systemic immunization with recombinant BCG PspA-PdT prime and protein boost correlates with cellular and humoral immune response in bronchoalveolar fluids (BALF)., PMID:31891153
Efficacy, safety and immunogenicity of a pneumococcal protein-based vaccine co-administered with 13-valent pneumococcal conjugate vaccine against acute otitis media in young children: A phase IIb randomized study., PMID:31629570
A Cross-Reactive Protein Vaccine Combined with PCV-13 Prevents Streptococcus pneumoniae- and Haemophilus influenzae-Mediated Acute Otitis Media., PMID:31308088
Necroptotic Cell Death Promotes Adaptive Immunity Against Colonizing Pneumococci., PMID:31019504
Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines - A phase II, randomised, observer-blind study in Gambian infants., PMID:30975570
Protein Expression Analysis by Western Blot and Protein-Protein Interactions., PMID:30929209
Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection., PMID:30562923
A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge., PMID:30530620
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival., PMID:30420782
Design and Biological Assembly of Polyester Beads Displaying Pneumococcal Antigens as Particulate Vaccine., PMID:33435075
Construction and evaluation of a whole-cell pneumococcal vaccine candidate., PMID:30133088
Multifaceted Role of Pneumolysin in the Pathogenesis of Myocardial Injury in Community-Acquired Pneumonia., PMID:29641429
Immunodominance in T cell responses elicited against different domains of detoxified pneumolysin PlyD1., PMID:29509778
Identification of SP1683 as a pneumococcal protein that is protective against nasopharyngeal colonization., PMID:29400602
Antibodies to PcpA and PhtD protect mice against Streptococcus pneumoniae by a macrophage- and complement-dependent mechanism., PMID:29135332
Safety and immunogenicity of a novel multiple antigen pneumococcal vaccine in adults: A Phase 1 randomised clinical trial., PMID:29132988
Cell Invasion and Pyruvate Oxidase-Derived H2O2 Are Critical for Streptococcus pneumoniae-Mediated Cardiomyocyte Killing., PMID:29061707
Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing., PMID:28841717
A Combination of Recombinant Mycobacterium bovis BCG Strains Expressing Pneumococcal Proteins Induces Cellular and Humoral Immune Responses and Protects against Pneumococcal Colonization and Sepsis., PMID:28768668
Safety, reactogenicity and immunogenicity of two investigational pneumococcal protein-based vaccines: Results from a randomized phase II study in infants., PMID:28729019
Systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant Plym2., PMID:28487097
Correlation of higher antibody levels to pneumococcal proteins with protection from pneumococcal acute otitis media but not protection from nasopharyngeal colonization in young children., PMID:28143785
Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides., PMID:28031178
Trivalent pneumococcal protein vaccine protects against experimental acute otitis media caused by Streptococcus pneumoniae in an infant murine model., PMID:27919628
Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea., PMID:27859014
For research use only. Not for human or drug use.
