Catalog No.
YHK04803
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln128-Phe248
Predicted molecular weight
15.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IWL2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Collectin-4, Pulmonary surfactant-associated protein A1, SFTP1, SP-A1, COLEC4, SP-A, PSP-A, SFTPA1, SFTPA1B, Alveolar proteinosis protein, SFTPA, PSPA, PSAP, 35 kDa pulmonary surfactant-associated protein
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells., PMID:40437524
Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease., PMID:40242753
Surfactant protein levels and genetic variants as biomarkers for COVID-19 severity in children., PMID:39832502
Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma., PMID:39599822
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury., PMID:39515667
Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease., PMID:39314485
Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children., PMID:39222066
Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus., PMID:38900131
Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury., PMID:38689083
Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model., PMID:38596675
High risk of lung cancer in surfactant-related gene variant carriers., PMID:38575158
Development of an in vitro human alveolar epithelial air-liquid interface model using a small molecule inhibitor cocktail., PMID:38500038
Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx., PMID:38375572
Sevoflurane with Low Concentration Decrease DNA Methylation on Chronic Obstructive Pulmonary Disease (COPD)-Related Gene Promoter in COPD Rat., PMID:38010369
Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia., PMID:37605849
Injury activated alveolar progenitors (IAAPs): the underdog of lung repair., PMID:37166489
[Interstitial lung diseases in children of genetic origin]., PMID:36564324
The Genetic and Epigenetic Footprint in Idiopathic Pulmonary Fibrosis and Familial Pulmonary Fibrosis: A State-of-the-Art Review., PMID:36553114
A potential treatment option for transformed small-cell lung cancer on PD-L1 inhibitor-based combination therapy improved survival., PMID:36473332
Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model., PMID:36200269
Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children., PMID:35903101
Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis., PMID:35720392
SNP-SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children., PMID:35401703
Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants., PMID:34917085
Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants., PMID:34671583
Lung cancer is also a hereditary disease., PMID:34670806
Comparative analysis on lung transcriptome of Mycoplasma ovipneumoniae (Mo) - infected Bashbay sheep and argali hybrid sheep., PMID:34645427
Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions., PMID:34484180
SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma., PMID:34181042
CRISPRi-mediated functional analysis of NKX2-1-binding sites in the lung., PMID:33980985
Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy., PMID:33863742
Krebs von den Lungen-6 and surfactant protein-A in interstitial pneumonia with autoimmune features., PMID:33530214
Genetic variants of small airways and interstitial pulmonary disease in children., PMID:33526882
miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/β-Catenin Signaling., PMID:33490270
SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population., PMID:33469544
Novel rare genetic variants in idiopathic pulmonary fibrosis., PMID:33361455
Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice., PMID:33141765
GLP-1 receptor agonist ameliorates experimental lung fibrosis., PMID:33093510
Genetic Features of Lung Adenocarcinoma with Ground- Glass Opacity: What Causes the Invasiveness of Lung Adenocarcinoma?, PMID:33020345
Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer., PMID:32855221
Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae., PMID:32670284
Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer., PMID:32587780
Association of SNP-SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure., PMID:32326132
Dexamethasone Treatment Increases the Intracellular Calcium Level Through TRPV6 in A549 Cells., PMID:32033337
Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis., PMID:32005219
Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival., PMID:31953311
SP-A and TLR4 localization in lung tissue of SM-exposed patients., PMID:31718931
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis., PMID:31601679
Persistent Respiratory Distress in the Term Neonate: Genetic Surfactant Deficiency Diseases., PMID:31544695
For research use only. Not for human or drug use.
