Catalog No.
YHC37002
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile218-Lys345
Predicted molecular weight
16.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08908
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
G-21, 5-HT-1A, 5-HT1A, ADRB2RL1, ADRBRL1, Serotonin receptor 1A, 5-hydroxytryptamine receptor 1A, HTR1A
In vivo serotonin 1A receptor distribution in treatment-resistant depression., PMID:40461473
Maternal high-fat diet exposure impairs LKB1-TGFβ1 inflammatory pathway and increases hypothalamic 5HT receptors gene expression and somatic growth in young rats., PMID:40381902
The interplay between SLC6A4 and HTR1A genetic variants that may lead to antidepressant failure., PMID:40335484
Characterization of the Molecular Mechanisms Underlying Lurasidone-Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach., PMID:40202273
Serotonin modulates infraslow oscillation in the dentate gyrus during non-REM sleep., PMID:40178074
Molecular Insights into Propofol's Neurotoxic Effects: Targeting the HTR1A/cAMP Signaling Pathway., PMID:40168001
Characterizing serotonin expression throughout bovine mammary gland developmental stages and its relationship with 17β-estradiol at puberty., PMID:40131888
Exploring therapeutic potential of Bacopa monnieri bioactive compounds against Alzheimer's and Parkinson's diseases., PMID:39959708
Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis., PMID:39839219
Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression., PMID:39809809
Disturbing sleep in female adolescent mice does not increase vulnerability to depression triggers later in life., PMID:39675644
Sex-stratified association of variants in the serotonin 1A receptor gene with acute crisis pain among African American patients with sickle cell disease., PMID:39615579
Therapeutic potential of mackerel-derived peptides and the synthetic tetrapeptide TVGF for sleep disorders in a light-induced anxiety zebrafish model., PMID:39600360
Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction., PMID:39415189
Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors., PMID:39396089
Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid., PMID:39394255
The interplay of serotonin 5-HT1A and 5-HT7 receptors in chronic stress., PMID:39279505
Anti-inflammatory effects of phytocannabinoids and terpenes on inflamed Tregs and Th17 cells in vitro., PMID:39208564
Association between 5-HT1A receptor C-1019G, 5-HTTLPR polymorphisms and panic disorder: a meta-analysis., PMID:39207450
Exploring Candidate Gene Studies and Alexithymia: A Systematic Review., PMID:39202385
Relationships between serotonin 1A receptor DNA methylation, self-reported history of childhood abuse and gray matter volume in major depression., PMID:39187183
Antidepressant Effect and Mechanism of Picea mariana Essential Oil on Reserpine-Induced Depression Model Mice., PMID:39113199
Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice., PMID:39085354
Six-compound combo remedy ameliorates corticosterone-induced depressive behaviors in mice via targeting 5-hydroxytryptamine receptor 1A signaling., PMID:39082750
Effect of amisulpride on the expression of serotonin receptors, neurotrophic factor BDNF and its receptors in mice with overexpression of the aggregation-prone [R406W] mutant tau protein., PMID:39027123
Association Study of Serotonin 1A Receptor Gene, Personality, and Anxiety in Women with Alcohol Use Disorder., PMID:38928270
5-hydroxytryptamine 2C/1A receptors modulate the biphasic dose response of the head twitch response and locomotor activity induced by DOM in mice., PMID:38916640
Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension., PMID:38906512
Shaoyao Decoction reduced T lymphocyte activation by regulating of intestinal flora and 5-hydroxytryptamine metabolism in ulcerative colitis., PMID:38879471
Non-Synonymous Substitutions in Cadherin 13, Solute Carrier Family 6 Member 4, and Monoamine Oxidase A Genes are Associated with Personality Traits in Thoroughbred Horses., PMID:38856811
Microbiota influence on behavior: Integrative analysis of serotonin metabolism and behavioral profile in germ-free mice., PMID:38822661
Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms., PMID:38678087
Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia., PMID:38573820
Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB expression in adult female rats., PMID:38552745
Molecular mechanisms of quetiapine bidirectional regulation of bipolar depression and mania based on network pharmacology and molecular docking: Evidence from computational biology., PMID:38518857
Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System., PMID:38473717
Living, Heat-Killed Limosilactobacillus mucosae and Its Cell-Free Supernatant Differentially Regulate Colonic Serotonin Receptors and Immune Response in Experimental Colitis., PMID:38398793
The effects of childhood maltreatment, recent interpersonal and noninterpersonal stress, and HPA-axis multilocus genetic variation on prospective changes in adolescent depressive symptoms: A multiwave longitudinal study., PMID:38389485
Therapeutic-like activity of cannabidiolic acid methyl ester in the MK-801 mouse model of schizophrenia: Role for cannabinoid CB1 and serotonin-1A receptors., PMID:38385841
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats., PMID:38172401
Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1 rs1049353 and an altered endocannabinoid system in depressed patients., PMID:37984468
Altered brain serotonin 5-HT1A receptor expression and function in juvenile Fmr1 knockout mice., PMID:37923121
Antioxioxidant and antiapoptotic effects of Thymosin β4 in Aβ-induced SH-SY5Y cells via the 5-HTR1A/ERK axis., PMID:37788276
Genetic contributions to brain serotonin transporter levels in healthy adults., PMID:37777558
Effects of Chronic Combined Treatment with Ketanserin and Fluoxetine in B6.CBA-D13Mit76C Recombinant Mice with Abnormal 5-HT1A Receptor Functional Activity., PMID:37748872
Chronic memantine disrupts spatial memory and up-regulates Htr1a gene expression in the hippocampus of GPR39 (zinc-sensing receptor) KO male mice., PMID:37716463
5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice., PMID:37659688
Long-term Impact of Prenatal Famine on Differential DNA Methylation of Genes in the Serotonin Receptor Signalling Pathway in Adults., PMID:37598834
ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders., PMID:37525034
Effects of serotonin transporter and receptor polymorphisms on depression., PMID:37453823
For research use only. Not for human or drug use.
