Catalog No.
YHN55201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu464
Predicted molecular weight
54.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5T447
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase HECTD3, HECT-type E3 ubiquitin transferase HECTD3, HECTD3, HECT domain-containing protein 3
Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non-Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning., PMID:40366616
Serum proteomic biomarker investigation of vascular depression using data-independent acquisition: a pilot study., PMID:38384936
The 'Other' subfamily of HECT E3 ubiquitin ligases evaluate the tumour immune microenvironment and prognosis in patients with hepatocellular carcinoma., PMID:38318939
HECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction., PMID:38267403
E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer., PMID:37422058
E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR., PMID:37402711
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells., PMID:37031183
HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway., PMID:36088509
Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis., PMID:35918322
HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway., PMID:35913790
HECTD3 enhances cell radiation resistance and migration by regulating LKB1 mediated ZEB1 in glioma., PMID:35768187
HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC., PMID:35397617
Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury., PMID:33627626
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3., PMID:33608556
Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib., PMID:33607208
Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role., PMID:33577134
Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells., PMID:33490650
iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells., PMID:33405298
The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice., PMID:33037313
The role of E3 ubiquitin ligase HECTD3 in cancer and beyond., PMID:31637449
The HECT ubiquitin E3 ligase Smurf2 degrades μ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells., PMID:30758996
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation., PMID:30741923
HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection., PMID:29920190
Down-regulation of HECTD3 by HER2 inhibition makes serous ovarian cancer cells sensitive to platinum treatment., PMID:28989055
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation., PMID:28716524
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients., PMID:28636940
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3., PMID:27508098
The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8., PMID:24287696
The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1., PMID:23358872
Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis., PMID:22820163
Thyroid hormone-regulated gene expression in juvenile mouse liver: identification of thyroid response elements using microarray profiling and in silico analyses., PMID:22206413
Interaction between syntaxin 8 and HECTd3, a HECT domain ligase., PMID:18821010
The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara., PMID:18194665
For research use only. Not for human or drug use.
