Catalog No.
EHK23201
Expression system
Mammalian cells
Species
Homo sapiens (Human)
Protein length
Met1-Gln199
Predicted molecular weight
47.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q93038
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Protein WSL-1, LARD, Lymphocyte-associated receptor of death, Tumor necrosis factor receptor superfamily member 25, Apo-3, Protein WSL, APO3, DR3, TNFRSF12, WSL, TNFRSF25, Death receptor 3, DDR3, WSL1
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders., PMID:40010414
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT., PMID:39896683
Effects of dioscin from Dioscorea nipponica on TL1A/DR3 and Th9 cells in a collagen-induced arthritis mouse model., PMID:39798473
The TL1A inhibitors in IBD: what's in the pot?, PMID:39772947
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment., PMID:39759895
Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD., PMID:39266053
Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8+ T cells and inhibited tumor growth., PMID:39142717
Anti-TL1A monoclonal antibody modulates the dysregulation of Th1/Th17 cells and attenuates granuloma formation in sarcoidosis by inhibiting the PI3K/AKT signaling pathway., PMID:38852524
An In Vitro Study on the Cytotoxic, Antioxidant, and Antimicrobial Properties of Yamogenin-A Plant Steroidal Saponin and Evaluation of Its Mechanism of Action in Gastric Cancer Cells., PMID:38731847
Transcriptomic analysis reveals the critical role of chemokine signaling in the anti-atherosclerosis effect of Xuefu Zhuyu decoction., PMID:38679399
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma., PMID:38493956
DR6 Augments Colorectal Cancer Cell Growth, Invasion, and Stemness by Activating AKT/NF-κB Pathway., PMID:38478147
The ever-expanding role of cytokine receptor DR3 in T cells., PMID:38359559
Tumor necrosis factor-like cytokine 1A plays a role in inflammatory bowel disease pathogenesis., PMID:37579137
Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption., PMID:37434162
Membrane tension-mediated stiff and soft tumor subtypes closely associated with prognosis for prostate cancer patients., PMID:37179366
The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells., PMID:36847849
Impact of BSG/CD147 gene expression on diagnostic, prognostic and therapeutic strategies towards malignant cancers and possible susceptibility to SARS-CoV-2., PMID:36574092
Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer., PMID:36352147
Meloxicam Inhibits Apoptosis in Neurons by Deactivating Tumor Necrosis Factor Receptor Superfamily Member 25, Leading to the Decreased Cleavage of DNA Fragmentation Factor Subunit α in Alzheimer's Disease., PMID:36279100
Prognosis Analysis and Validation of Fatty Acid Metabolism-Related lncRNAs and Tumor Immune Microenvironment in Cervical Cancer., PMID:35942212
Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review., PMID:35911746
Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada., PMID:35588757
Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments., PMID:35405299
TL1A/DR3 Axis, A Key Target of TNF-a, Augments the Epithelial-Mesenchymal Transformation of Epithelial Cells in OVA-Induced Asthma., PMID:35359966
Energy Metabolism-Related Gene Prognostic Index Predicts Biochemical Recurrence for Patients With Prostate Cancer Undergoing Radical Prostatectomy., PMID:35280985
Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma., PMID:35063404
Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells., PMID:34831323
Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma., PMID:34662447
Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders., PMID:34305924
Use of Post-transplant Cyclophosphamide Treatment to Build a Tolerance Platform to Prevent Liquid and Solid Organ Allograft Rejection., PMID:33737937
Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis., PMID:33710266
Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score ≥ 7., PMID:33628338
Multiplex gene targeting in the mouse embryo using a Cas9-Cpf1 hybrid guide RNA., PMID:33421768
Role of Myeloid-Derived Suppressor Cells in High-Dose-Irradiated TRAMP-C1 Tumors: A Therapeutic Target and an Index for Assessing Tumor Microenvironment., PMID:33188861
TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses., PMID:33177161
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo., PMID:33097818
DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus., PMID:32948777
TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants., PMID:32827707
Association between prenatal bisphenol a exposure and promoter hypermethylation of CAPS2, TNFRSF25, and HKR1 genes in cord blood., PMID:32763279
Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells., PMID:32750370
The Role of the TL1A/DR3 Axis in the Activation of Group 2 Innate Lymphoid Cells in Subjects with Eosinophilic Asthma., PMID:32584596
Molecular signature of slowly expanding lesions in progressive multiple sclerosis., PMID:32577755
Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression., PMID:32439702
The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens., PMID:32397343
Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder., PMID:32139808
The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells., PMID:31628153
Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia., PMID:31608721
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours., PMID:31603207
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice., PMID:31592235
For research use only. Not for human or drug use.
