Catalog No.
YHE90101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile113
Predicted molecular weight
14.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51948
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p36, MNAT1, MAT1, Menage a trois, Cyclin-G1-interacting protein, RING finger protein MAT1, RING finger protein 66, RNF66, CDK7/cyclin-H assembly factor, p35, CAP35, CDK-activating kinase assembly factor MAT1
CCNE2 promotes cisplatin resistance and affects prognosis of head and neck squamous cell carcinoma by targeting MNAT1., PMID:40269062
Integrative analysis of serum proteomics and transcriptomics in hepatitis C., PMID:40082995
Pan-cancer analysis combined with experimental validation revealed that KTN1 is an immunological and prognostic biomarker., PMID:39697730
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression., PMID:39511379
Structural basis of Cdk7 activation by dual T-loop phosphorylation., PMID:39097586
[Bioinformatics-based analysis of the effect of general Transcription Factor IIH on prognosis of Prostate cancer]., PMID:38644292
Epigenetic upregulation of MNAT1 by SMYD2 is linked to PI3K/AKT activation and tumorigenesis of pancreatic adenocarcinoma., PMID:37232506
Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair., PMID:36793865
Identification of Key Genes and Pathways Associated with Preeclampsia by a WGCNA and an Evolutionary Approach., PMID:36421809
A systematic review of inter-individual differences in the DNA repair processes involved in melphalan monoadduct repair in relation to treatment outcomes., PMID:34347127
Ixazomib inhibits myeloma cell proliferation by targeting UBE2K., PMID:33647537
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis., PMID:33556114
Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease., PMID:33296651
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway., PMID:33272245
Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients., PMID:32663249
Characterization of Meta-Iodobenzylguanidine (mIBG) Transport by Polyspecific Organic Cation Transporters: Implication for mIBG Therapy., PMID:32487736
The regulatory effect of has-circ-0001146/miR-26a-5p/MNAT1 network on the proliferation and invasion of osteosarcoma., PMID:32453410
In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair., PMID:32245994
[MNAT1 expression in non-small cell lung cancer and its biological cellular impact]., PMID:31422594
MAT1 facilitates the lung metastasis of osteosarcoma through upregulation of AKT1 expression., PMID:31421084
Activated hippo signal pathway inhibits cell proliferation and promotes apoptosis in NK/T cell lymphoma cells., PMID:31124291
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases., PMID:31110295
The complete structure of the human TFIIH core complex., PMID:30860024
MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance., PMID:30477538
Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer., PMID:27301701
ADRM1-amplified metastasis gene in gastric cancer., PMID:26052681
Genetic variants in DNA repair genes as potential predictive markers for oxaliplatin chemotherapy in colorectal cancer., PMID:25778469
Reconstruction of canine diffuse large B-cell lymphoma gene regulatory network: detection of functional modules and hub genes., PMID:25678421
Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand., PMID:25210803
Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6., PMID:25093993
Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia., PMID:24885447
An intragenic deletion of the gene MNAT1 in a family with pectus deformities., PMID:24664931
DNA repair gene patterns as prognostic and predictive factors in molecular breast cancer subtypes., PMID:24072219
The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts., PMID:23765726
Lack of CAK complex accumulation at DNA damage sites in XP-B and XP-B/CS fibroblasts reveals differential regulation of CAK anchoring to core TFIIH by XPB and XPD helicases during nucleotide excision repair., PMID:23083890
Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network., PMID:21994455
CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes., PMID:21778139
Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis., PMID:21663587
Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover., PMID:21385826
Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches., PMID:20624369
Y-box binding protein 1 is up-regulated in proliferative breast cancer and its inhibition deregulates the cell cycle., PMID:20596676
Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos., PMID:20231280
Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation., PMID:18981214
Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23., PMID:18259683
[Experimental study of MAT1 gene silencing mediated by siRNA in pancreatic cancer]., PMID:18167254
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7., PMID:17901130
Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population., PMID:17707548
Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells., PMID:17628022
Corepressor MMTR/DMAP1 is involved in both histone deacetylase 1- and TFIIH-mediated transcriptional repression., PMID:17371848
Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1., PMID:17276355
For research use only. Not for human or drug use.
