Catalog No.
YHB89101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu149-Lys412
Predicted molecular weight
32.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P00966
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ASS1, Citrulline--aspartate ligase, Argininosuccinate synthase, ASS
Arginine promotes the activation of human lung fibroblasts independent of its metabolism., PMID:40454944
LM2I leads to CAD ubiquitination and liver cancer suppression through activation of ASS1., PMID:40448443
Integrated Amino Acid Profiling and 4D-DIA Proteomics Reveal Protein Quality Divergence and Metabolic Adaptation in Cordyceps Species., PMID:40422699
In-silico discovery of type-2 diabetes-causing host key genes that are associated with the complexity of monkeypox and repurposing common drugs., PMID:40370100
Proteomic analysis reveals potential biomarker candidates in serous ovarian tumors - a preliminary study., PMID:40330446
TAMing immunity through an unexpected source., PMID:40315841
Crataegus pinnatifida polysaccharide alleviates DSS-induced colitis in mice by regulating the intestinal microbiota and enhancing arginine biosynthesis., PMID:40315641
Etoposide-induced protein 2.4 homolog promotes argininosuccinate synthase 1 and cancer cell survival upon arginine deprivation., PMID:40253325
Metabolic remodelling produces fumarate via the aspartate-argininosuccinate shunt in macrophages as an antiviral defence., PMID:40251448
ASS1 is a hub gene and possible therapeutic target for regulating metabolic dysfunction-associated steatotic liver disease modulated by a carbohydrate-restricted diet., PMID:40244373
Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy., PMID:40161384
Role of genetic factors in imatinib resistance of chronic myeloid leukemia: P53, RB1, ASS1 gene deletions, and chromosome 8 hyperdiploidy., PMID:40156964
Proteomic Changes Associated With Endogenous FBXW7 Mutations in Moderately Differentiated Endometrial Cancer Cells Include Increased TROP2 and Galectin-3 Levels., PMID:40087851
Glucose and Insulin Differently Regulate Gluconeogenic and Ureagenic Gene Expression., PMID:40024748
Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-Sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis., PMID:39991825
BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation-Induced Apoptosis., PMID:39898973
Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance., PMID:39868332
Development of a Genetically Encoded Sensor for Arginine., PMID:39837760
Rbfox3 Promotes Transformation of MDSC-Like Tumor Cells to Shape Immunosuppressive Microenvironment., PMID:39777898
Danhong injection modulates microglial polarization and neuroinflammation via the JUNB/NF-κB pathway in ischemic stroke., PMID:39694424
Visualization of argininosuccinate synthetase by in silico analysis: novel insights into citrullinemia type I disorders., PMID:39649700
Endothelial cell Ass1 inhibits arteriosclerotic calcification in diabetes mellitus., PMID:39642445
Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts., PMID:39554075
The Mechanism of TRIM21 Inhibiting the Invasion and Migration of ccRCC by Stabilizing ASS1., PMID:39513657
Met-Flow analyses of the metabolic heterogeneity associated with different stages of cord blood-derived hematopoietic cell differentiation., PMID:39483465
Unveiling genetic variants: Tetra-primer ARMS-PCR diagnosis and structural insights into BLAD, BC, and DUMPS in Pakistani cattle herds., PMID:39235569
Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis., PMID:39194244
FoxO transcription factors regulate urea cycle through Ass1., PMID:39191148
An integrated bioinformatics analysis to identify the shared biomarkers in patients with obstructive sleep apnea syndrome and nonalcoholic fatty liver disease., PMID:39081807
Metabolomics Combined with Physiology and Transcriptomics Reveal the Response of Samsoniella hepiali to Key Metabolic Pathways and Its Degradation Mechanism during Subculture., PMID:39061849
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response., PMID:38965441
Exploration and verification a 13-gene diagnostic framework for ulcerative colitis across multiple platforms via machine learning algorithms., PMID:38951638
Quantitative Proteomics Provided Insights into the Protective Effects of Heat Acclimation on the Rat Hypothalamus after Exertional Heatstroke., PMID:38940089
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response., PMID:38858597
Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants., PMID:38759626
ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis., PMID:38710705
[Shenqi Chongcao Formula ameliorates inflammatory response in rats with pulmonary fibrosis by activating the ASS1/src/STAT3 signaling pathway]., PMID:38708496
Pseudodendritic keratitis in citrullinemia; a report of an unusual and novel ocular finding in this metabolic disorder., PMID:38601192
Oncogenic KRAS Induces Arginine Auxotrophy and Confers a Therapeutic Vulnerability to SLC7A1 Inhibition in Non-Small Cell Lung Cancer., PMID:38502865
The strain-dependent cytostatic activity of Lactococcus lactis on CRC cell lines is mediated through the release of arginine deiminase., PMID:38481270
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation., PMID:38448615
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer., PMID:38364944
Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism., PMID:38283944
Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis., PMID:38233193
Optical Genome Mapping Helps to Identify BCR::JAK2 Rearrangement Arising from Cryptic Complex Chromosomal Aberrations: A Case Report and Literature Review., PMID:38137010
ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae., PMID:38113552
A pan-cancer analysis of the role of argininosuccinate synthase 1 in human tumors., PMID:38053661
Case report: Diagnosis of ADCY5-related dyskinesia explaining the entire phenotype in a patient with atypical citrullinemia type I., PMID:38020658
Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice., PMID:38013089
Inhibition of HSP90 in Driver Oncogene-Defined Lung Adenocarcinoma Cell Lines: Key Proteins Underpinning Therapeutic Efficacy., PMID:37762133
For research use only. Not for human or drug use.
