Catalog No.
YHB83501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val299-Ser542
Predicted molecular weight
29.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O96013
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p21-activated kinase 4, Serine/threonine-protein kinase PAK 4, KIAA1142, PAK-4, PAK4
The MASTL/YBX1/PAK4 axis regulated by stress-activated STK24 triggers lenvatinib resistance and tumor progression in hepatocellular carcinoma., PMID:40456026
Design, Synthesis, and Biological Evaluation of Selective PAK4 Degrader for the Treatment of Lung Tumor Metastasis., PMID:40404481
The Role of the p21-Activated Kinase Family in Tumor Immunity., PMID:40332759
Red blood cell-tumor cell interactions promote tumor cell progression., PMID:40301999
Combined anti-PD-L1 and anti-VEGFR2 therapy promotes the antitumor immune response in GBM by reprogramming tumor microenvironment., PMID:40180890
The role and application of Coronin family in human tumorigenesis and immunomodulation., PMID:40154644
Determinants of response and molecular dynamics in HER2+ER+ breast cancers from the NA-PHER2 trial receiving HER2-targeted and endocrine therapies., PMID:40038334
p21-Activated Kinase 4 and Ischemic Acute Kidney Injury in Mice and Humans., PMID:40019790
HSPB1 Orchestrates the Inflammation-Associated Transcriptome Profile of Atherosclerosis in HUVECs., PMID:40018940
The Important Role of p21-Activated Kinases in Pancreatic Exocrine Function., PMID:40001881
PAK4 promotes the cytoskeletal organization and meiotic maturation via phosphorylating DDX17 in oocyte., PMID:39948582
Transketolase promotes osteosarcoma progression through the YY1-PAK4 axis., PMID:39853945
Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization., PMID:39852144
Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4., PMID:39833606
Quantum DFT analysis and molecular docking investigation of various potential breast cancer drugs., PMID:39545283
KGF secreted from HSCs activates PAK4/BMI1, promotes HCC stemness through PI3K/AKT pathway., PMID:39544166
PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation., PMID:39435597
Design, synthesis and biological evaluation of novel benzimidazole-derived p21-activited kinase 4 (PAK4) inhibitors bearing a 4-(4-methylpiperazin-1-yl)phenyl scaffold as potential antitumor agents., PMID:39427518
Inhibition of NAMPT by PAK4 Inhibitors., PMID:39337621
Remifentanil-induced inflammation in microglial cells: Activation of the PAK4-mediated NF-κB/NLRP3 pathway and onset of hyperalgesia., PMID:39322089
PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients., PMID:39273017
Targeting RAC1 reactivates pyroptosis to reverse paclitaxel resistance in ovarian cancer by suppressing P21-activated kinase 4., PMID:39224538
Prognostic Significance of Elevated UCHL1, SNRNP200, and PAK4 Expression in High-Grade Clear Cell Renal Cell Carcinoma: Insights from LC-MS/MS Analysis and Immunohistochemical Validation., PMID:39199615
PAK4 phosphorylates and inhibits AMPKα to control glucose uptake., PMID:39127697
Metformin Prevents Tumor Cell Growth and Invasion of Human Hormone Receptor-Positive Breast Cancer (HR+ BC) Cells via FOXA1 Inhibition., PMID:39000600
PAK4-targeted PROTACs in clear cell renal cell carcinoma: a two-for-one targeted and immune therapy?, PMID:38924842
Identification of exosomal microRNAs and related hub genes associated with imatinib resistance in chronic myeloid leukemia., PMID:38916832
PAK4 inhibition augments anti-tumour effect by immunomodulation in oral squamous cell carcinoma., PMID:38890401
A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction., PMID:38885414
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway., PMID:38824479
Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα., PMID:38815861
Development of a PAK4-targeting PROTAC for renal carcinoma therapy: concurrent inhibition of cancer cell proliferation and enhancement of immune cell response., PMID:38810561
Tumorigenic role of Pak4 in ovarian cancer and its correlation with immune infiltration., PMID:38807162
Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity., PMID:38797819
Retracted: Interfering with pak4 Protein Expression Affects Osteosarcoma Cell Proliferation and Migration., PMID:38549986
Synthesis of novel (R)-carvone-tagged thiazolidinone as anticancer leads: characterization, in vitro antiproliferative evaluation and in silico studies., PMID:38523573
Interaction between p21-activated kinase 4 and β-catenin as a novel pathway for PTH-dependent osteoblast activation., PMID:38497504
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer., PMID:38424218
Identification of P21 (CDKN1A) Activated Kinase 4 as a Susceptibility Gene for Familial Non-Medullary Thyroid Carcinoma., PMID:38411500
p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL., PMID:38216738
Different Transcriptome Features of Peripheral Blood Mononuclear Cells in Non-Emphysematous Chronic Obstructive Pulmonary Disease., PMID:38203236
Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors., PMID:38065082
Design, synthesis and anticancer activity evaluation of 4-(3-1H-indazolyl)amino quinazoline derivatives as PAK4 inhibitors., PMID:37864885
PAK4 inhibition significantly potentiates Gemcitabine activity in PDAC cells via inhibition of Wnt/β-catenin, p-ERK/MAPK and p-AKT/PI3K pathways., PMID:37720313
Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers., PMID:37703579
miR-224-5p acts as a tumour suppressor and reverses the resistance to BRAF inhibitor in melanoma through directly targeting PAK4 to block the MAPK pathway., PMID:37611431
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1., PMID:37591884
Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth., PMID:37138671
PAK4-relevant proliferation reduced by cell autophagy via p53/mTOR/p-AKT signaling., PMID:37033362
Baicalein Inhibits the Growth of Transplanted Esophageal Cancer in Mice and the Effect on the Expression of PAK4., PMID:36899200
For research use only. Not for human or drug use.
