Catalog No.
YHB83201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly361
Predicted molecular weight
40.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O96008
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PEREC1, TOM40, TOMM40, Mitochondrial import receptor subunit TOM40 homolog, C19orf1, p38.5, Protein Haymaker, Translocase of outer membrane 40 kDa subunit homolog
USP30 Aggravating the Malignant Progression of Breast Cancer and Its Resistance to Tamoxifen by Inhibiting the Ubiquitination of TOMM40., PMID:40227042
Comparative transcriptomic and co-expression network analysis identifies key gene modules involved in heat stress responses in goats., PMID:39956229
TREM1 interferes with macrophage mitophagy via the E2F1-mediated TOMM40 transcription axis in rheumatoid arthritis., PMID:39793906
TOMM40 may mediate GFAP, neurofilament light Protein, pTau181, and brain morphometry in aging., PMID:39760103
Association of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease neuroimaging markers., PMID:39713891
Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease., PMID:39619635
Analysis of Alzheimer's disease associated deleterious non-synonymous single nucleotide polymorphisms and their impacts on protein structure and function by performing in-silico methods., PMID:39589570
TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway., PMID:39489289
Mass spectrometry-based proteomics to study mutants and interactomes of mitochondrial translocation proteins., PMID:39488372
The Large GTPase Guanylate-Binding Protein-1 (GBP-1) Promotes Mitochondrial Fission in Glioblastoma., PMID:39457021
Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project., PMID:39428839
TOMM40-APOE chimera linking Alzheimer's highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesis., PMID:39416128
Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1)., PMID:39408926
Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia., PMID:39079537
Translocase of Outer Mitochondrial Membrane 40, as a Promising Biomarker for the Diagnosis of Polycystic Ovary Syndrome and Pan-Cancer., PMID:39060752
BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40., PMID:38978225
[Mechanisms of the Effect of Maternal Age-Related Oocyte Aging on Fertility: Transcriptomic Sequencing Analysis of a Zebrafish Model]., PMID:38948296
Long-read sequencing for 29 immune cell subsets reveals disease-linked isoforms., PMID:38806455
Effect of low ethanol concentration in maturation medium on developmental ability, mitochondria, and gene expression profile in mouse oocytes., PMID:38772287
[Genetic basis of postoperative cognitive dysfunction]., PMID:38676676
Pan-Cancer Analysis of the Prognostic and Immunological Role of TOMM40 to Identify Its Function in Breast Cancer., PMID:38649557
Exploring Genetic Associations of 3 Types of Risk Factors With Ischemic Stroke: An Integrated Bioinformatics Study., PMID:38591222
On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries., PMID:38563508
APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response., PMID:38424036
Multi-class Modeling Identifies Shared Genetic Risk for Late-onset Epilepsy and Alzheimer's Disease., PMID:38370677
Heat stroke-induced cerebral cortex nerve injury by mitochondrial dysfunction: A comprehensive multi-omics profiling analysis., PMID:38342446
TOMM40 Correlates with Cholesterol and is Predictive of a Favorable Prognosis in Endometrial Carcinoma., PMID:38231050
Uncovering the Localization and Function of a Novel Read-Through Transcript 'TOMM40-APOE'., PMID:38201273
Classifying Alzheimer's disease and normal subjects using machine learning techniques and genetic-environmental features., PMID:38044212
Mitochondrial influences on smooth muscle phenotype., PMID:38009196
Patient with PSEN1 Glu318Gly and Other Possible Disease Risk Mutations, Diagnosed with Early Onset Alzheimer's Disease., PMID:37895139
Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study., PMID:37874111
Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes., PMID:37804609
TOMM40 '523 Genotype Distinguishes Patterns of Cognitive Improvement for Executive Function in APOEɛ3 Homozygotes., PMID:37718796
Alzheimer's Disease Genetic Influences Impact the Associations between Diet and Resting-State Functional Connectivity: A Study from the UK Biobank., PMID:37571327
The APOE-TOMM40 Humanized Mouse Model: Characterization of Age, Sex, and PolyT Variant Effects on Gene Expression., PMID:37458041
APOE Locus-Associated Mitochondrial Function and Its Implication in Alzheimer's Disease and Aging., PMID:37445616
TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes., PMID:37425714
Effect of a low ethanol concentration during in vitro maturation of bovine oocytes and subsequent embryo development., PMID:37331264
Aggregation-prone Tau impairs mitochondrial import, which affects organelle morphology and neuronal complexity., PMID:37303235
Exome sequencing of choreoacanthocytosis reveals novel mutations in VPS13A and co-mutation in modifier gene(s)., PMID:37209156
Presequence protease reverses mitochondria-specific amyloid-β-induced mitophagy to protect mitochondria., PMID:37002885
TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease., PMID:36835494
Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia., PMID:36750708
Combined proteomics and single cell RNA-sequencing analysis to identify biomarkers of disease diagnosis and disease exacerbation for systemic lupus erythematosus., PMID:36524113
An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration., PMID:36517509
MicroRNA-22-3p Restrains the Proliferation, Phenotypic Transformation, and Migration of Vascular Smooth Muscle Cells by Manipulating TOMM40., PMID:36450556
An AS-qPCR-based method for the detection of Alzheimer's disease-related SNPs., PMID:36436137
Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease biomarkers., PMID:36399096
APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages., PMID:36330582
For research use only. Not for human or drug use.
