Catalog No.
YHB82201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Ile202
Predicted molecular weight
24.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95997
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PTTG1, Esp1-associated protein, EAP1, Securin, TUTR1, PTTG, hPTTG, Pituitary tumor-transforming gene 1 protein, Tumor-transforming protein 1
Pituitary tumor transforming gene 1 and endocrine cancers: an up-to-date review through history, current insights and future perspectives., PMID:40472369
Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study., PMID:40407808
Identification of key biomarker genes in liver hepatocellular carcinoma and kidney renal clear cell carcinoma progression: A shared high-throughput screening and molecular docking method with potentials for targeted therapeutic interventions., PMID:40390492
Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder., PMID:40367801
Four genes shared between rheumatoid arthritis and cervical cancer are associated with cervical cancer prognosis., PMID:40335617
A comprehensive review and in silico analysis of the role of survivin (BIRC5) in hepatocellular carcinoma hallmarks: A step toward precision., PMID:40306500
Valproic acid promotes transcriptional activation of Drd2 by mediating histone acetylation to inhibit the mTOR-Pttg1 signaling axis and exerts anti-PitNETs activity., PMID:40220407
Transcriptionally distinct malignant neuroblastoma populations show selective response to adavosertib treatment., PMID:40118716
Cell Migration in Endometriosis Responds to Omentum-Derived Molecular Cues Similar to Ovarian Cancer., PMID:40076450
The Role of RAC2 and PTTG1 in Cancer Biology., PMID:40072059
RNA sequencing identifies MAP1A and PTTG1 as predictive genes of aging CD264+ human mesenchymal stem cells at an early passage., PMID:39980838
Biomarker Panels Associated with Diagnosis and Overall Survival in Hepatocellular Carcinoma Revealed from Protein-Protein and mRNA-miRNA Interaction Networks., PMID:39874008
Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells., PMID:39849583
Exploring potential key genes and pathways associatedwith hepatocellular carcinoma prognosis through bioinformatics analysis, followed by experimental validation., PMID:39822558
The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments., PMID:39792809
Association between transcription factors expression and growth patterns of nonfunctioning pituitary adenomas., PMID:39747515
Decoding the prognostic landscape of LUAD: the interplay between N6-methyladenosine modification and immune microenvironment., PMID:39720723
Comprehensive analysis of the pituitary tumor-transforming gene (PTTG) family in lung adenocarcinoma: diagnostic, prognostic, and therapeutic implications., PMID:39678599
Knockdown of KLF6 ameliorates myocardial infarction by regulating autophagy via transcriptional regulation of PTTG1., PMID:39652418
The combination of serum lncRNA PTTG3P and mRNA PTTG1 serves as a diagnostic and prognostic marker for hepatocellular carcinoma., PMID:39635828
RNA Sequencing Reveals That the Genes Related to Cell Cycle and Glycolysis Play an Essential Role in IL-27-Induced Keratinocyte Hyperproliferation., PMID:39525318
Multi-omics analysis identifies PTTG1 as a prognostic biomarker associated with immunotherapy and chemotherapy resistance., PMID:39455949
Multi-omic analysis revealed the immunological patterns and diagnostic value of exhausted T cell-derived PTTG1 in patients with psoriasis., PMID:39342798
Restoration of ARA metabolic disorders in vascular smooth muscle cells alleviates intimal hyperplasia., PMID:39265882
Identification of Hub Genes in Comorbidity of Psoriasis and Vitiligo Using Bioinformatics Analysis., PMID:39258216
Therapeutic Potential of PLK1, KIF4A, CDCA5, UBE2C, CDT1, SKA3, AURKB, and PTTG1 Genes in Triple-Negative Breast Cancer: Correlating Their Expression with Sensitivity to GSK 461364 and IKK 16 Drugs., PMID:39214909
Pituitary tumor‑transforming gene 1 regulates the senescence and apoptosis of oral squamous cell carcinoma in a p21‑dependent DNA damage response manner., PMID:39155881
Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model., PMID:39153120
MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte., PMID:39093409
KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells., PMID:38926398
IFIH1-mediated post-transcriptional regulation of PTTG1 promotes proliferation and affects PHA-848125 sensitivity and prognosis in oropharyngeal carcinoma., PMID:38859832
Combinatorial metabolomic and transcriptomic analysis of muscle growth in hybrid striped bass (female white bass Morone chrysops x male striped bass M. saxatilis)., PMID:38858615
SKA3/PTTG1/c-MYC signal loop drives the progression of colorectal cancer., PMID:38849978
Identification and Verification of Metabolism-related Immunotherapy Features and Prognosis in Lung Adenocarcinoma., PMID:38500277
Upregulated expression of PTTG1 is associated with progression of pancreatic cancer., PMID:38482253
Multi-Omics Analysis of the Oncogenic Value of Pituitary Tumor-Transforming Gene 1 (PTTG1) in Human Cancers., PMID:38420810
A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide., PMID:38124114
Novel 2 Gene Signatures Associated With Breast Cancer Proliferation: Insights From Predictive Differential Gene Expression Analysis., PMID:38104894
SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma., PMID:38069214
Transcriptome analysis of meiotic and post-meiotic spermatogenic cells reveals the potential hub genes of aging on the decline of male fertility., PMID:37839768
UBE2C serves as a prognosis biomarker of uterine corpus endometrial carcinoma via promoting tumor migration and invasion., PMID:37803076
Cancer Stem Cell Markers-Clinical Relevance and Prognostic Value in High-Grade Serous Ovarian Cancer (HGSOC) Based on The Cancer Genome Atlas Analysis., PMID:37628927
Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis., PMID:37583701
Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries., PMID:37460698
A novel investigation into an E2F transcription factor-related prognostic model with seven signatures for colon cancer patients., PMID:37431829
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity., PMID:37400529
Identification of several inflammation-related genes based on bioinformatics and experiments., PMID:37301122
PTTG1 Enhances Oncolytic Adenovirus 5 Entry into Pancreatic Adenocarcinoma Cells by Increasing CXADR Expression., PMID:37243239
Gene Expression Pattern of ESPL1, PTTG1 and PTTG1IP Can Potentially Predict Response to TKI First-Line Treatment of Patients with Newly Diagnosed CML., PMID:37174118
PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression., PMID:37159932
For research use only. Not for human or drug use.
