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Recombinant Human AGR2/HPC8 Protein, N-His

Catalog #:   YHB81901 Specific References (50) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O95994
Protein length: Arg21-Leu175
Overview

Catalog No.

YHB81901

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Arg21-Leu175

Predicted molecular weight

20.13 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O95994

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

AGR2, AG-2, AG2, Anterior gradient protein 2 homolog, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human AGR2/HPC8 protein
References

Agr2 in cancer and beyond: unraveling its role during protein synthesis, ER stress, and as a predictive biomarker., PMID:40471515

Discovery of new protein partners of anterior gradient 2 (AGR2) from cell-cell adhesion pathway using genetically-encoded photo-crosslinker DiZPK., PMID:40367911

Distribution of epithelial endoplasmic reticulum stress-related proteins in adult and pediatric Crohn's disease: Association with inflammation and fibrosis., PMID:40300947

AGR2 activates the TGF-β/Smad signaling pathway to promote epithelial-mesenchymal transition, invasion, and metastasis in nasopharyngeal carcinoma., PMID:40119906

AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3., PMID:40085973

N-terminal histone acetyltransferase NAA40 modulates osteosarcoma progression by controlling AGR2 expression., PMID:40020320

Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation., PMID:39971962

Human cytomegalovirus UL82 promotes cell cycle progression of colorectal cancer by upregulating AGR2., PMID:39962326

Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy., PMID:39914384

A Novel AGR2 Variant Causing Aberrant Monomer-Dimer Equilibrium Leading to Severe Respiratory and Digestive Symptoms., PMID:39673647

Prevalence and Significance of AGR2 Expression in Human Cancer., PMID:39533806

AGR2 knockdown induces ER stress and mitochondria fission to facilitate pancreatic cancer cell death., PMID:39353469

Characterization of the AGR2-NPM3 axis uncovers the AGR2 involvement in PD-L1 regulation in colorectal cancer., PMID:39300184

AGR2 facilitates teratoma progression by regulating glycolysis via the AnXA2/EGFR axis., PMID:39197578

AGR2: The Covert Driver and New Dawn of Hepatobiliary and Pancreatic Cancer Treatment., PMID:39062458

Potential toxicity of graphene (oxide) quantum dots via directly covering the active site of anterior gradient homolog 2 protein., PMID:38528032

Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family., PMID:38411504

Heterogeneity of small duct- and large duct-type intrahepatic cholangiocarcinoma., PMID:38409827

A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer., PMID:38391955

Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors., PMID:38341509

Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study., PMID:38288749

A mucus production programme promotes classical pancreatic ductal adenocarcinoma., PMID:38262672

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells., PMID:38177498

LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment., PMID:37924160

Pancreatic ductal adenocarcinoma with acinar-to-ductal metaplasia-like cancer cells shows increased cellular proliferation., PMID:37659916

AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer., PMID:37568077

Bioinformatics analysis and single-cell RNA sequencing: elucidating the ubiquitination pathways and key enzymes in lung adenocarcinoma., PMID:37559628

Clinical value of serum and tissue AGR2 for diagnosis and prognosis in epithelial ovarian cancer., PMID:37284743

Potential Role of AGR2 for Mammalian Skin Wound Healing., PMID:37175601

Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells., PMID:37121942

Transcriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients., PMID:36812168

AGR2 Gene Expression in Glioblastoma: A Novel Molecular Potential Target for Diagnosis and Treatment., PMID:36622190

Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance., PMID:36595821

Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer., PMID:36593009

AGR2 protein expression in colorectal tumour epithelialcompartment., PMID:36591613

Glutamine promotes O-GlcNAcylation of G6PD and inhibits AGR2 S-glutathionylation to maintain the intestinal mucus barrier in burned septic mice., PMID:36565645

Fatty acid metabolism-related signature predicts survival in patients with clear cell renal carcinoma., PMID:36516496

Differentially expressed messenger RNA/proteins can distinguish teratoma from necrosis in postchemotherapy retroperitoneal lymph node dissection tissue., PMID:36504384

The anterior gradient homologue 2 (AGR2) co-localises with the glucose-regulated protein 78 (GRP78) in cancer stem cells, and is critical for the survival and drug resistance of recurrent glioblastoma: in situ and in vitro analyses., PMID:36482387

Anterior Gradient 2 is a Significant Prognostic Biomarker in Bone Metastasis of Breast Cancer., PMID:36405393

Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis., PMID:36384110

ESE1/AGR2 axis antagonizes TGF-β-induced epithelial-mesenchymal transition in low-grade pancreatic cancer., PMID:36329620

AGR2 expression as a predictive biomarker for therapy response in esophageal squamous cell carcinoma., PMID:36327302

Knock-Out of the Five Lysyl-Oxidase Family Genes Enables Identification of Lysyl-Oxidase Pro-Enzyme Regulated Genes., PMID:36232621

Integrated Bioinformatics Analysis for the Screening of Hub Genes and Therapeutic Drugs in Androgen Receptor-Positive TNBC., PMID:36157217

Gene Expression Markers of Prognostic Importance for Prostate Cancer Risk in Patients with Benign Prostate Hyperplasia., PMID:36086411

Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma., PMID:36003068

Secretin alleviates biliary and liver injury during late-stage primary biliary cholangitis via restoration of secretory processes., PMID:35987275

Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection., PMID:35967328

The circRNA circADAMTS6 promotes progression of ESCC and correlates with prognosis., PMID:35962061

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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For research use only. Not for human or drug use.

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Recombinant Human AGR2/HPC8 Protein, N-His [YHB81901]
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