Catalog No.
YHB81901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg21-Leu175
Predicted molecular weight
20.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95994
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AGR2, AG-2, AG2, Anterior gradient protein 2 homolog, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog
Agr2 in cancer and beyond: unraveling its role during protein synthesis, ER stress, and as a predictive biomarker., PMID:40471515
Discovery of new protein partners of anterior gradient 2 (AGR2) from cell-cell adhesion pathway using genetically-encoded photo-crosslinker DiZPK., PMID:40367911
Distribution of epithelial endoplasmic reticulum stress-related proteins in adult and pediatric Crohn's disease: Association with inflammation and fibrosis., PMID:40300947
AGR2 activates the TGF-β/Smad signaling pathway to promote epithelial-mesenchymal transition, invasion, and metastasis in nasopharyngeal carcinoma., PMID:40119906
AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3., PMID:40085973
N-terminal histone acetyltransferase NAA40 modulates osteosarcoma progression by controlling AGR2 expression., PMID:40020320
Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation., PMID:39971962
Human cytomegalovirus UL82 promotes cell cycle progression of colorectal cancer by upregulating AGR2., PMID:39962326
Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy., PMID:39914384
A Novel AGR2 Variant Causing Aberrant Monomer-Dimer Equilibrium Leading to Severe Respiratory and Digestive Symptoms., PMID:39673647
Prevalence and Significance of AGR2 Expression in Human Cancer., PMID:39533806
AGR2 knockdown induces ER stress and mitochondria fission to facilitate pancreatic cancer cell death., PMID:39353469
Characterization of the AGR2-NPM3 axis uncovers the AGR2 involvement in PD-L1 regulation in colorectal cancer., PMID:39300184
AGR2 facilitates teratoma progression by regulating glycolysis via the AnXA2/EGFR axis., PMID:39197578
AGR2: The Covert Driver and New Dawn of Hepatobiliary and Pancreatic Cancer Treatment., PMID:39062458
Potential toxicity of graphene (oxide) quantum dots via directly covering the active site of anterior gradient homolog 2 protein., PMID:38528032
Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family., PMID:38411504
Heterogeneity of small duct- and large duct-type intrahepatic cholangiocarcinoma., PMID:38409827
A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer., PMID:38391955
Unraveling the impact of cancer-associated fibroblasts on hypovascular pancreatic neuroendocrine tumors., PMID:38341509
Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study., PMID:38288749
A mucus production programme promotes classical pancreatic ductal adenocarcinoma., PMID:38262672
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells., PMID:38177498
LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment., PMID:37924160
Pancreatic ductal adenocarcinoma with acinar-to-ductal metaplasia-like cancer cells shows increased cellular proliferation., PMID:37659916
AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer., PMID:37568077
Bioinformatics analysis and single-cell RNA sequencing: elucidating the ubiquitination pathways and key enzymes in lung adenocarcinoma., PMID:37559628
Clinical value of serum and tissue AGR2 for diagnosis and prognosis in epithelial ovarian cancer., PMID:37284743
Potential Role of AGR2 for Mammalian Skin Wound Healing., PMID:37175601
Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells., PMID:37121942
Transcriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients., PMID:36812168
AGR2 Gene Expression in Glioblastoma: A Novel Molecular Potential Target for Diagnosis and Treatment., PMID:36622190
Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance., PMID:36595821
Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer., PMID:36593009
AGR2 protein expression in colorectal tumour epithelialcompartment., PMID:36591613
Glutamine promotes O-GlcNAcylation of G6PD and inhibits AGR2 S-glutathionylation to maintain the intestinal mucus barrier in burned septic mice., PMID:36565645
Fatty acid metabolism-related signature predicts survival in patients with clear cell renal carcinoma., PMID:36516496
Differentially expressed messenger RNA/proteins can distinguish teratoma from necrosis in postchemotherapy retroperitoneal lymph node dissection tissue., PMID:36504384
The anterior gradient homologue 2 (AGR2) co-localises with the glucose-regulated protein 78 (GRP78) in cancer stem cells, and is critical for the survival and drug resistance of recurrent glioblastoma: in situ and in vitro analyses., PMID:36482387
Anterior Gradient 2 is a Significant Prognostic Biomarker in Bone Metastasis of Breast Cancer., PMID:36405393
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis., PMID:36384110
ESE1/AGR2 axis antagonizes TGF-β-induced epithelial-mesenchymal transition in low-grade pancreatic cancer., PMID:36329620
AGR2 expression as a predictive biomarker for therapy response in esophageal squamous cell carcinoma., PMID:36327302
Knock-Out of the Five Lysyl-Oxidase Family Genes Enables Identification of Lysyl-Oxidase Pro-Enzyme Regulated Genes., PMID:36232621
Integrated Bioinformatics Analysis for the Screening of Hub Genes and Therapeutic Drugs in Androgen Receptor-Positive TNBC., PMID:36157217
Gene Expression Markers of Prognostic Importance for Prostate Cancer Risk in Patients with Benign Prostate Hyperplasia., PMID:36086411
Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma., PMID:36003068
Secretin alleviates biliary and liver injury during late-stage primary biliary cholangitis via restoration of secretory processes., PMID:35987275
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection., PMID:35967328
The circRNA circADAMTS6 promotes progression of ESCC and correlates with prognosis., PMID:35962061
For research use only. Not for human or drug use.
