Catalog No.
YHB80401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser26-Phe443
Predicted molecular weight
73.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95967
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EGF-containing fibulin-like extracellular matrix protein 2, Protein UPH1, Fibulin-4, FBLN4, EFEMP2, FIBL-4
Proteome-driven transcriptomic dissection of EMT networks in bladder cancer based on the VIM and CDH2 protein macromolecules influence: From molecular-protein subtyping to therapeutic target prioritization., PMID:40419050
Fibulin-4 and latent-transforming growth factor beta-binding protein-4 interactions with syndecan-2 and syndecan-3 are required for elastogenesis., PMID:40168061
Developing and validating a prognostic disulfidptosis-related signature for glioblastoma: predicting radioresistance and synergestic effect with immunotherapy., PMID:40100446
Plasma Extracellular Matrix Protein 2 Level as a Predictive Biomarker for Rupture of Small Intracranial Aneurysms., PMID:40080244
Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study., PMID:39919076
Case Report and literature review: Delayed diagnosis of ARCL1B due to a newly reported homozygous mutation c.464A>C p. (Tyr155Ser) in the EFEMP2 gene., PMID:39764439
Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid., PMID:39342078
Construction of store-operated calcium entry-related gene signature for predicting prognosis and indicates immune microenvironment infiltration in stomach adenocarcinomas., PMID:39333689
Unraveling genetic threads: Identifying novel therapeutic targets for allergic rhinitis through Mendelian randomization., PMID:39040085
Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases., PMID:38950604
Discovery of pathogenic variants in EFEMP2 and RAG1 and undetectable fetal phenotype: A challenge of prenatal exome sequencing., PMID:38923535
The extracellular matrix protein EFEMP2 is involved in the response to VHSV infection in the olive flounder Paralichthys olivaceus., PMID:38871142
Fibulin-4 as a potential extracellular vesicle marker of fibrosis in patients with cirrhosis., PMID:38853023
Identification of Prognostic Markers of Glioblastoma through Bioinformatics Analysis., PMID:38639614
Potential diagnostic markers and therapeutic targets for periodontitis and Alzheimer's disease based on bioinformatics analysis., PMID:38189472
Whole-exome sequencing uncovers a novel EFEMP2 gene variant (c.C247T) associated with dominant nonsyndromic thoracic aortic aneurysm., PMID:38113391
The genes significantly associated with an improved prognosis and long-term survival of glioblastoma., PMID:38019838
Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization., PMID:37982173
Potassium voltage‑gated channel subfamily E member 4 facilitates the malignant progression of colon cancer by enhancing EGF containing fibulin extracellular matrix protein 2 expression., PMID:37456174
EFEMP2 upregulates PD-L1 expression via EGFR/ERK1/2/c-Jun signaling to promote the invasion of ovarian cancer cells., PMID:37420173
Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs., PMID:37400563
In silico Identification of Hypoxic Signature followed by reverse transcription-quantitative PCR Validation in Cancer Cell Lines., PMID:36624663
EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis., PMID:36351433
STEAP2 promotes osteosarcoma progression by inducing epithelial-mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2., PMID:36316642
EFEMP2 increases the invasion ability of cervical cancer cells by promoting EMT via the Raf/MEK/ERK signaling pathway., PMID:36004647
Downregulation of fibulin-4 inhibits autophagy and promotes the sensitivity of esophageal squamous cell carcinoma cells to apatinib by activating the Akt-mTOR signaling pathway., PMID:35950373
Osteogenesis imperfecta in 140 Turkish families: Molecular spectrum and, comparison of long-term clinical outcome of those with COL1A1/A2 and biallelic variants., PMID:34902613
Case Report: Occurrence of Severe Thoracic Aortic Aneurysms (Involving the Ascending, Arch, and Descending Segments) as a Result of Fibulin-4 Deficiency: A Rare Pathology With Successful Management., PMID:34901216
Sevoflurane-Induced miR-211-5p Promotes Neuronal Apoptosis by Inhibiting Efemp2., PMID:34730432
An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level., PMID:34080027
Identifying Molecular Signatures of Distinct Modes of Collective Migration in Response to the Microenvironment Using Three-Dimensional Breast Cancer Models., PMID:33804802
Interdependence of metals and its binding proteins in Parkinson's disease for diagnosis., PMID:33398051
Association of Development of Solar Elastosis with Increased Expression of Fibrillin-1, LTBP-2 and Fibulin-4 in Combination with Decreased Expression of LTBP-4., PMID:33372682
99-Case Study of Sporadic Aortic Dissection by Whole Exome Sequencing Indicated Novel Disease-Associated Genes and Variants in Chinese Population., PMID:33083483
Pre-Operative Fasting Provides Long Term Protection Against Chronic Renal Damage Induced by Ischaemia Reperfusion Injury in Wild Type and Aneurysm Prone Fibulin-4 Mice., PMID:33032926
Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic seizures., PMID:33011347
Bioinformatic screening and identification of downregulated hub genes in adrenocortical carcinoma., PMID:32765768
Role of PAR1-Egr1 in the Initiation of Thoracic Aortic Aneurysm in Fbln4-Deficient Mice., PMID:32580633
EFEMP2 indicates assembly of M0 macrophage and more malignant phenotypes of glioma., PMID:32396873
EFEMP2 Suppresses the Invasion of Lung Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition (EMT) and Down-Regulating MMPs., PMID:32110039
Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review., PMID:31957502
EFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo., PMID:31802903
EFEMP2 suppresses epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human bladder cancer., PMID:31592144
Fibulin-4 exerts a dual role in LTBP-4L-mediated matrix assembly and function., PMID:31548410
miR-211-5p contributes to chondrocyte differentiation by suppressing Fibulin-4 expression to play a role in osteoarthritis., PMID:31396630
Recent updates on the molecular network of elastic fiber formation., PMID:31395654
Cost-comparison analysis of FIB-4, ELF and fibroscan in community pathways for non-alcoholic fatty liver disease., PMID:31296161
Molecular dynamics simulations on human fibulin-4 mutants D203A and E126K reveal conformational changes in EGF domains potentially responsible for enhanced protease lability and impaired extracellular matrix assembly., PMID:31125616
For research use only. Not for human or drug use.
