Catalog No.
YHB76001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu102-Asp613
Predicted molecular weight
58.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95831
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AIFM1, AIF, Programmed cell death protein 8, PDCD8, Apoptosis-inducing factor 1, mitochondrial
Bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method., PMID:40491693
Apoptosis-inducing factor (AIF) at the crossroad of cell survival and cell death: implications for cancer and mitochondrial diseases., PMID:40468311
Establishment and validation of a novel risk model based on PANoptosis-related genes to predict prognosis in head and neck squamous cell carcinoma., PMID:40324259
OLFML3 Promotes IRG1 Mitochondrial Localization and Modulates Mitochondrial Function in Macrophages., PMID:40083707
MIA40 suppresses cell death induced by apoptosis-inducing factor 1., PMID:40055465
AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis., PMID:39979311
Mechanism of action of Danlou tablets affecting MAFLD via KEAP1-mediated oxeiptosis., PMID:39978447
Chemical Proteomics Reveals Human Off-Targets of Fluoroquinolone Induced Mitochondrial Toxicity., PMID:39964703
[Effect of acupuncture on the oxeiptosis Kelch-like ECH-associated protein 1/phosphoglycerate mutase 5/mitochondrial apoptosis-inducing factor 1 signaling pathway in rats with diminished ovarian reserve]., PMID:39961758
Penehyclidine hydrochloride activates PARK2 and modulates ubiquitination of AIFM1 to rescue renal tubular injury in diabetic kidney disease., PMID:39828393
NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism., PMID:39806100
Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus., PMID:39764561
African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation., PMID:39707514
Identification of host proteins that interact with African swine fever virus pE301R., PMID:39629325
TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway., PMID:39551802
Genomic and phenotypic landscapes of X-linked hereditary hearing loss in the Chinese population., PMID:39272213
Baicalin Ameliorates Cartilage Injury in Rats With Osteoarthritis via Modulating miR-766-3p/AIFM1 Axis., PMID:39264083
The KEAP1/PGAM5/AIFM1-Mediated oxeiptosis pathway in Alzheimer's disease., PMID:39168265
Impact of combined intermittent fasting and high-intensity interval training on apoptosis and atrophy signaling in rat fast- and slow-twitch muscles., PMID:39138135
Hyperglycemia-induced oxidative stress exacerbates mitochondrial apoptosis damage to cochlear stria vascularis pericytes via the ROS-mediated Bcl-2/CytC/AIF pathway., PMID:39092597
The Effect of Oleuropein in AIF and MMP-9 in Traumatic Brain Injury Rat Model., PMID:39092504
Unlocking cardioprotection: iPSC exosomes deliver Nec-1 to target PARP1/AIFM1 axis, alleviating HF oxidative stress and mitochondrial dysfunction., PMID:39061056
Dual Inhibition of PI3 Kinase and MAP Kinase Signaling Pathways in Intrahepatic Cholangiocellular Carcinoma Cell Lines Leads to Proliferation Arrest but Not Apoptosis., PMID:39057080
TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis., PMID:38823435
Synaptic vesicle protein 2A mitigates parthanatos via apoptosis-inducing factor in a rat model of pharmacoresistant epilepsy., PMID:38801174
PARP1 inhibition prevents oxidative stress in age-related hearing loss via PAR-Ca2+-AIF axis in cochlear strial marginal cells., PMID:38735540
Rotator Cuff Tendinopathy: Pathways of Apoptosis., PMID:38695498
NS7a of SADS-CoV promotes viral infection via inducing apoptosis to suppress type III interferon production., PMID:38624231
Ketamine induces insomnia-like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse., PMID:38567678
CHCHD4 binding affects the active site of apoptosis inducing factor (AIF): Structural determinants for allosteric regulation., PMID:38460521
Clinical and genetic architecture of a large cohort with auditory neuropathy., PMID:38456936
AIF translocation into nucleus caused by Aifm1 R450Q mutation: generation and characterization of a mouse model for AUNX1., PMID:38449065
Augmented mitochondrial apoptotic signaling impairs C2C12 myoblast differentiation following cellular aging through sequential passaging., PMID:38212955
Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis., PMID:38156770
[KEAP1/PGAM5/AIFM1 mediated oxeiptosis pathway in TDCIPP-induced reduction of TM4 cell viability]., PMID:38115663
CDK5R1, GSE1, HSPG2 and WDFY3 as indirect epigenetic-sensitive genes in atrial fibrillation., PMID:37991085
A Novel AIFM1-Related Disorder Phenotype Treated with Deep Brain Stimulation., PMID:37787095
4-Octyl itaconate inhibits inflammation to attenuate psoriasis as an agonist of oxeiptosis., PMID:37741130
Alantolactone triggers oxeiptosis in human ovarian cancer cells via Nrf2 signaling pathway., PMID:37712005
Expanding the spectrum of neonatal-onset AIFM1-associated disorders., PMID:37644805
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency., PMID:37603145
Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice., PMID:37466197
Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant., PMID:37365177
Whole-exome sequencing detected a novel AIFM1 variant in a Han-Chinese family with Cowchock syndrome., PMID:37173762
Copper metabolism in cell death and autophagy., PMID:37055935
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis., PMID:37000625
p20BAP31 induces cell apoptosis via both AIF caspase-independent and the ROS/JNK mitochondrial pathway in colorectal cancer., PMID:36977989
Nano-selenium protects grass carp hepatocytes against 4-tert-butylphenol-induced mitochondrial apoptosis and necroptosis via suppressing ROS-PARP1 axis., PMID:36924910
Targeting oxeiptosis-mediated tumor suppression: a novel approach to treat colorectal cancers by sanguinarine., PMID:36914635
For research use only. Not for human or drug use.
