Catalog No.
YHB74601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile725-Lys925
Predicted molecular weight
25.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95786
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Probable ATP-dependent RNA helicase DDX58, Retinoic acid-inducible gene I protein, RIG-1, DEAD box protein 58, RLR-1, DDX58, Retinoic acid-inducible gene 1 protein, Antiviral innate immune response receptor RIG-I, RIG-I-like receptor 1, RIG-I
LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling., PMID:40495222
Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice., PMID:40456736
Identification of therapeutic targets for psoriatic arthritis through proteomics., PMID:40439986
Mitochondrial Antiviral Signaling Protein Activation by Retinoic Acid-Inducible Gene I Agonist Triggers Potent Antiviral Defense in Umbilical Cord Mesenchymal Stromal Cells Without Compromising Mitochondrial Function., PMID:40429828
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion., PMID:40413207
Zebrafish CD44a variants suppress antiviral immunity through regulation of RIG-I ubiquitination and degradation., PMID:40412572
Changes in Generations of PAMAM Dendrimers and Compositions of Nucleic Acid Nanoparticles Govern Delivery and Immune Recognition., PMID:40391736
Gasdermin E links tumor cell-intrinsic nucleic acid signaling to proinflammatory cell death for successful checkpoint inhibitor cancer immunotherapy., PMID:40366863
STAT3-mediated upregulation of TRIM6 promotes hepatocellular carcinoma invasion through the DDX58-Snail1 axis., PMID:40348925
Integration of bulk RNA-seq and scRNA-seq reveals transcriptomic signatures associated with deep vein thrombosis., PMID:40342960
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
RNF157 targets RIG-I/DDX58 to promote proliferation in liver cancer., PMID:40312343
Palmitoyl-transferase 3 promotes mitochondrial antiviral signaling protein degradation by modulating its ubiquitination., PMID:40300684
Exploring the Role of Inflammation and Metabolites in Bell's Palsy and Potential Treatment Strategies., PMID:40299566
Therapy-induced senescent glioblastoma cells sustain a procancer immune microenvironment by activating DDX58-mediated STAT1 signaling., PMID:40259469
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing., PMID:40229436
METTL3 depletion blocks vesicular stomatitis virus replication in pancreatic cancer cells through the establishment of an intrinsic antiviral state., PMID:40214229
The ELF3-TRIM22-MAVS signaling axis regulates type I interferon and antiviral responses., PMID:40162781
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
RIG-I and cGAS mediate antimicrobial and inflammatory responses of primary osteoblasts and osteoclasts to Staphylococcus aureus., PMID:40135931
RIG-I-driven CDKN1A stabilization reinforces cellular senescence., PMID:40133712
ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation., PMID:40126553
LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes., PMID:40121229
Upregulation of RIG-I is Critical for Responsiveness to IFN-α Plus Anti-PD-1 in Colorectal Cancer., PMID:40116486
Immunoengineering of a Photocaged 5´-triphosphate Oligoribonucleotide Ligand for Spatiotemporal Control of RIG-I Activation in Cancer., PMID:40095771
SRSF10 regulates isoform expression of transcripts associated with proliferative diabetes retinopathy in ARPE-19 cells based on long-read RNA and immunoprecipitation sequencing., PMID:40090530
Overexpression of LMOD1 induces oxidative stress and enhances cell apoptosis of melanoma through the RIG-I like receptor pathway., PMID:40068386
The structural basis of TRIM25-mediated regulation of RIG-I., PMID:40024477
Immune Imbalance in Primary Membranous Nephropathy at Single-cell Resolution., PMID:40018947
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein., PMID:40006954
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways., PMID:39994288
A small interfering RNA inhibits lung fibroblast-myofibroblast differentiation via simultaneously knockingdown CELF1 and activating RIG-I signalling., PMID:39993608
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation., PMID:39986258
RNF135 promotes the stemness of breast cancer cells by ubiquitinating and degrading DDX58., PMID:39986189
Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses., PMID:39983719
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling., PMID:39964752
Elevated expression and reduced phosphorylation of uterine RIG-I protein in a murine model of pathogenic preterm labor., PMID:39946161
Synthetic RIG-I-Agonist RNA Induces Death of Hepatocellular Carcinoma Cells., PMID:39945619
HCoV-229E Mpro Suppresses RLR-Mediated Innate Immune Signalling Through Cleavage of NEMO and Through Other Mechanisms., PMID:39940968
Convalescent COVID-19 monocytes exhibit altered steady-state gene expression and reduced TLR2, TLR4 and RIG-I induced cytokine expression., PMID:39922089
Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virus., PMID:39919747
Identification of IFI27 involvement in the progression of neuroblastoma through bioinformatics analysis and experimental assays., PMID:39915361
Heightened expression of type I interferon signaling genes in CD4+ T cells from acutely HIV-1-infected women is associated with lower viral loads., PMID:39902043
Serum Immune-Response Protein Biomarkers Based on Olink Technology for Diagnosis of Ischemic Stroke., PMID:39900546
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses., PMID:39874992
Dengue Virus Replicative-Form dsRNA Is Recognized by Both RIG-I and MDA5 to Activate Innate Immunity., PMID:39873327
VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity., PMID:39868467
Proteomic Analysis of Differentially Expressed Proteins in A549 Cells Infected with H9N2 Avian Influenza Virus., PMID:39859371
The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling., PMID:39841800
Human microRNA miR-197-3p positively regulates HIV-1 virion infectivity through its target DDX52 by stabilizing Vif protein expression., PMID:39826696
For research use only. Not for human or drug use.
