Catalog No.
YHB67301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln20-Gln526
Predicted molecular weight
59.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95479
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GDH, 6PGL, Glucose 1-dehydrogenase, H6PD, Glucose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein
Using proteomics and single-cell sequencing to analyze the pathogenesis of recurrent implantation failure associated with uterine natural killer cells., PMID:40514455
A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner., PMID:40281598
Transcriptomic Analysis Reveals Dynamics of Gene Expression in Liver Tissue of Spotted Sea Bass Under Acute Thermal Stress., PMID:39432208
Multi-organ transcriptomics analysis of a slowly growing fish rock carp (Procypris rabaudi) reveals insights into mechanism of growth rate regulation., PMID:39423654
The Glucose-Glutamine Metabolic Interplay in MCF-7 Cells, a Hormone-Sensitive Breast Cancer Model., PMID:39082337
Identification of immune-inflammation targets for intracranial aneurysms: a multiomics and epigenome-wide study integrating summary-data-based Mendelian randomization, single-cell-type expression analysis, and DNA methylation regulation., PMID:39051921
Unraveling the genetic architecture of congenital vertebral malformation with reference to the developing spine., PMID:38321032
Mandatory role of endoplasmic reticulum and its pentose phosphate shunt in the myocardial defense mechanisms against the redox stress induced by anthracyclines., PMID:38082185
G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity., PMID:37855366
Multi-tissue transcriptome-wide association study reveals susceptibility genes and drug targets for insulin resistance-relevant phenotypes., PMID:37779362
High-resolution structural-omics of human liver enzymes., PMID:37289586
Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females., PMID:35441887
Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection., PMID:35030165
Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?, PMID:34439897
Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation., PMID:34039740
Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia., PMID:33864926
Tumor-suppressive microRNA-551b-3p targets H6PD to inhibit gallbladder cancer progression., PMID:33250514
Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats., PMID:32997989
Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma., PMID:32594352
A heretical view: rather than a solely placental protective function, placental 11β hydroxysteroid dehydrogenase 2 also provides substrate for fetal peripheral cortisol synthesis in obese pregnant ewes., PMID:32151296
Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction., PMID:32075690
Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses., PMID:30909744
Alterations of Cortisol Metabolism in Human Disorders., PMID:29843121
Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation., PMID:29427591
Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance., PMID:29295867
Fructose increases corticosterone production in association with NADPH metabolism alterations in rat epididymal white adipose tissue., PMID:28499147
Amphetamine withdrawal differentially affects hippocampal and peripheral corticosterone levels in response to stress., PMID:27208490
Metabolic Coupling Determines the Activity: Comparison of 11β-Hydroxysteroid Dehydrogenase 1 and Its Coupling between Liver Parenchymal Cells and Testicular Leydig Cells., PMID:26528718
Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population., PMID:26452272
Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation., PMID:24983772
Reduced cellular Mg²⁺ content enhances hexose 6-phosphate dehydrogenase activity and expression in HepG2 and HL-60 cells., PMID:24631573
Expression of mineralocorticoid and glucocorticoid receptors in preautonomic neurons of the rat paraventricular nucleus., PMID:24381176
Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer., PMID:23507704
Changing glucocorticoid action: 11β-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation., PMID:23435016
Sexually dimorphic effects of maternal nutrient reduction on expression of genes regulating cortisol metabolism in fetal baboon adipose and liver tissues., PMID:23238295
Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts., PMID:23125313
Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes., PMID:21869537
Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness., PMID:21858044
Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome., PMID:21803757
Expression of hexose-6-phosphate dehydrogenase in rat tissues., PMID:21620971
Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1., PMID:21325058
Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes., PMID:21052977
Contribution of hexose-6-phosphate dehydrogenase to NADPH content and redox environment in the endoplasmic reticulum., PMID:20500987
Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis., PMID:19935835
Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension., PMID:19837774
11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets., PMID:18779947
Constant expression of hexose-6-phosphate dehydrogenase during differentiation of human adipose-derived mesenchymal stem cells., PMID:18586838
Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy., PMID:18222920
Analysis of fifteen positional candidate genes for Schnyder crystalline corneal dystrophy., PMID:16163269
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency., PMID:12858176
For research use only. Not for human or drug use.
