Catalog No.
YHB47901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro47-Asn339
Predicted molecular weight
35.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94905
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Erlin-2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, SPFH domain-containing protein 2, ERLIN2, Endoplasmic reticulum lipid raft-associated protein 2, C8orf2, SPFH2
Genome-wide association studies of the fatty acid composition of Korean native chicken breast meat., PMID:40264524
Biallelic variants in ERLIN1: a series of 13 individuals with spastic paraparesis., PMID:39367212
The erlin1/erlin2 complex binds to and stabilizes phosphatidylinositol 3-phosphate and regulates autophagy., PMID:39018973
ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway., PMID:38782601
Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer., PMID:38643190
Expanding SPG18 clinical spectrum: autosomal dominant mutation causes complicated hereditary spastic paraplegia in a large family., PMID:38607533
Hereditary spastic paraparesis type 18 (SPG18): new ERLIN2 variants in a series of Italian patients, shedding light upon genetic and phenotypic variability., PMID:38427163
Novel ERLIN2 variant expands the phenotype of Spastic Paraplegia 18., PMID:38159148
KCNN1 promotes proliferation and metastasis of breast cancer via ERLIN2-mediated stabilization and K63-dependent ubiquitination of Cyclin B1., PMID:37831636
A novel autosomal dominant ERLIN2 variant activates endoplasmic reticulum stress in a Chinese HSP family., PMID:37752894
A case report of concurrent occurrence of two inherited axonopathies within a family: the benefit of whole-exome sequencing., PMID:37712628
Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection., PMID:37683630
Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells., PMID:37647408
Disruption of Intracellular Calcium Homeostasis Leads to ERLIN2-Linked Hereditary Spastic Paraplegia in Patient-Derived Stem Cell Models., PMID:40225166
Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation., PMID:35947953
Binding of the erlin1/2 complex to the third intralumenal loop of IP3R1 triggers its ubiquitin-proteasomal degradation., PMID:35568199
Identification of epilepsy concomitant candidate genes recognized in Saudi epileptic patients., PMID:35363364
Phenoconversion from Spastic Paraplegia to ALS/FTD Associated with CYP7B1 Compound Heterozygous Mutations., PMID:34946825
Role of ERLINs in the Control of Cell Fate through Lipid Rafts., PMID:34572057
Novel monoallelic variant in ERLIN2 causes spastic paraplegia converted to amyotrophic lateral sclerosis., PMID:34536826
EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2., PMID:34406391
14-3-3 and erlin proteins differentially interact with RIPK2 complexes., PMID:34152391
Identification of Biomarkers Related to CD8+ T Cell Infiltration With Gene Co-expression Network in Lung Squamous Cell Carcinoma., PMID:33816462
Molecular and Immune Characteristics for Lung Adenocarcinoma Patients With ERLIN2 Overexpression., PMID:33424830
Genomic Characteristics and Selection Signatures in Indigenous Chongming White Goat (Capra hircus)., PMID:32973871
Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas., PMID:32928922
SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis., PMID:32883232
Expansion of the genetic landscape of ERLIN2-related disorders., PMID:32147972
An autosomal dominant ERLIN2 mutation leads to a pure HSP phenotype distinct from the autosomal recessive ERLIN2 mutations (SPG18)., PMID:32094424
Proteomic Changes in Human Sperm During Sequential in vitro Capacitation and Acrosome Reaction., PMID:31824947
Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia., PMID:31636353
Palmitoylation of Hepatitis C Virus NS2 Regulates Its Subcellular Localization and NS2-NS3 Autocleavage., PMID:31597774
Exome Sequencing Identifies a Mutation (Y740C) in Spastic Paraplegia 7 Gene Associated with Adult-Onset Primary Lateral Sclerosis in a Chinese Family., PMID:31117107
The erlin2 T65I mutation inhibits erlin1/2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding., PMID:30135210
MiR-410 Acts as a Tumor Suppressor in Estrogen Receptor-Positive Breast Cancer Cells by Directly Targeting ERLIN2 via the ERS Pathway., PMID:30016800
A novel heterozygous variant in ERLIN2 causes autosomal dominant pure hereditary spastic paraplegia., PMID:29528531
ERLIN1 mutations cause teenage-onset slowly progressive ALS in a large Turkish pedigree., PMID:29453415
MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver., PMID:29321595
Associating transcription factors and conserved RNA structures with gene regulation in the human brain., PMID:28720872
Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus., PMID:28614383
Identification of commonly altered genes between in major depressive disorder and a mouse model of depression., PMID:28596527
Novel Mutations in Endoplasmic Reticulum Lipid Raft-associated Protein 2 Gene Cause Pure Hereditary Spastic Paraplegia Type 18., PMID:27824013
The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia., PMID:26209915
The critical role of membralin in postnatal motor neuron survival and disease., PMID:25977983
A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression., PMID:27462423
Arsenite-induced changes in hepatic protein abundance in cynomolgus monkeys (Macaca fascicularis)., PMID:24866292
Proteomic analysis of detergent resistant membrane domains during early interaction of macrophages with rough and smooth Brucella melitensis., PMID:24643124
Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis., PMID:24217618
Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms., PMID:23897027